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Generic tools

 

Cellular models :

  • In vitro model:
    • Oligodendrocytes and neuronal co-cultures (primary cells) – Multiple Sclerosis
    • Rat/mouse primary cell cultures of neurons/astrocytes/ or mixed cultures – Alzheimer’s Disease
    • Primary cell cultures of mouse/rat dopaminergic (mesencephalic) neurons (with or without astrocytes) - Parkinson’s Disease
    • Primary cell cultures of mouse/rat dopaminergic (mesencephalic) neurons and microglial     cells - Parkinson’s Disease
    • Primary cell cultures of mouse/rat (cortical and/or striatal) neurons – Huntington’s Disease
    • Human ESC and/or iPS cells obtained from HD patients
    • Human dopaminergic iPS cells – Parkinson’s Disease
  • Cellular models for high-throughput screening of molecules inducing the differentiation of oligodendrocyte precursor (OPC) cells (cell line CG4 with double fluorescence) 

 

Relevant animal models (transgenic , chemical and surgical approaches):

  • Xenopus - Multiple Sclerosis
  • Zebra fish - Parkinson's Disease
  • Murine - Multiple Sclerosis, Alzheimer's Disease, Parkinson's Disease, Huntington's Disease
  • Non-human Primate - Multiple Sclerosis, Alzheimer's Disease, Parkinson's Disease, Huntington's Disease
  • Models of blood-brain barrier (murine and humanized)

 

Biobanks :

  • Multiple Sclerosis : CRB- REFGENSEP and SEP / NeuroCEB
  • Alzheimer's Disease: -
  • Huntington Disease: ESC or iPS cells
  • Parkinson's Disease –

Biocollections : bio-collections.org/

 

Characterized cohorts of patients :

  • Multiple Sclerosis : OFSEP Cohort
  • Alzheimer's Disease: MultiMa cohort and INSIGHT cohort
  • Parkinson's Disease : Active File of 4000 patients of Pitié-Salpetriere and Henri Mondor Hospitals ; DIGPD cohort (430 patients); ICEBERG cohort (330 patients)
  • Huntington's Disease : Network of french-speaking Huntington’s patients



 

  •     Clinical and preclinical neuroimaging systems (11.7T , 7T , 3T MRI / PET-CT / SPECT)
  •     Innovative MRI and PET tracers (cyclotron and radiochemistry) associated with predictive biomarkers
  •     Electrophysiology (MEG and EEG)
  •     Ex vivo imaging (histology and histopathology GLP)
  •     Cell Imaging Platform (light and electron microscopy )



 


  • Vectorology platform dedicated to gene transfer experiments (production of transgenic animals), GMP cell and gene production centers (clinical batches for phase I / II)
  • Bank of AAV and Lentiviral vectors (1,500 constructs buildings) and vector production
  • Production of stem cells

 



 

  • Behavioral analysis (motor and cognitive) Platform
  • High-Tech walk  Platform
  • Neurophysiology
  • Surgery and Neurosurgery Platform
  • Eye Tracking System
  • Applied Immunology (experimental models and in vitro and in vivo antibody tittering (in animals or patients)
  • High-throughput real time PCR and Pyrosequencer
  • Biochemistry and Proteomics
  • Transciptomic Analysis
  • Pharmacokinetics and the correlation between molecular pharmacokinetics and pharmacodynamics