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A new target to treat spinocerebellar ataxia ?

Spinocerebellar ataxias are genetic neurodegenerative diseases of the cerebellum and brainstem causing numerous motor disorders, for which no curative or preventive therapies are available. SCA3 or Machado-Joseph disease (MJD) is the most prevalent ataxia worldwide. In their work published on June 14 in Acta Neuropathologica, Nathalie Cartier-Lacave, researcher from Inserm at the Brain and Spine Institute and NeurATRIS member, and her team have discovered the crucial role of an enzyme allowing to alleviate symptoms of the disease in mice.

Read the complete press release on the ICM website (in French): https://icm-institute.org/fr/actualite/nouvelle-cible-therapeutique-traiter-ataxies-spinocerebelleuses/

Scientific Publication:

RESTORING BRAIN CHOLESTEROL TURNOVER IMPROVES AUTOPHAGY AND HAS THERAPEUTIC POTENTIAL IN MOUSE MODELS OF SPINOCEREBELLAR ATAXIA.

Nóbrega C, Mendonça L, Marcelo A, Lamazière A, Tomé S, Despres G, Matos CA, Mechmet F, Langui D, den Dunnen W, de Almeida LP, Cartier N, Alves S.

Acta Neuropathol. 2019 Jun 14.

 

Multiple sclerosis: when the system gets carried away - France Culture

Two researchers members of NeurATRIS, Catherine Lubetzki and Bernard Zalc, talked about research and therapy progress on multiple sclerosis on Monday, June 17, 2019 on the radio France Culture (in French).

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NeurATRIS Webinars 2019 videos are online

The research infrastructures NeurATRIS and EATRIS offered on April 17 and May 6, 2019 two webinars dedicated to biological and technological tools for translational research on neurodegenerative diseases: in vivo preclinical models, jointly organized with the infrastructure Celphedia, and ultra high field MRI and MRS, jointly organized with the infrastructure France Life Imaging.

Watch the videos online: https://eatris.eu/solutions/transmedacademy/

NeurATRIS @ NeuroFrance 2019

The next NeuroFrance conference will take place at Parc Chanot, in Marseille, on May 22-24, 2019, with the support of NeurATRIS. Meet us on our booth or during the sessions specifically supported by NeurATRIS and co-organized by its members: "Shaping and imaging CNS myelin" on May 22 11AM-1PM and "Development and heterogeneity of primary brain tumors" on May 24 3:30-5:30PM.

Find out more : https://www.neurosciences.asso.fr/V2/colloques/SN19/