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Track record : projets finalisés ou en cours

THERAPIE CELLULAIRE

Pre-clinical assessment of pluripotent stem cell therapy for Huntington’s disease

COORDINATION

A. Perrier (BIRD)

PARTENAIRES

P. Hantraye (CEA), David Sourdive (Cellectis)

FINANCEMENT

ANR RFSC 2011-2014 & NeuroStemCell FP7 project

REPAIR-HD : Human pluripotent stem cell differenciation, safety and preparation for therapeutic transplantation in Huntington's disease

COORDINATION

A. Rosser

PARTENAIRES

A.Perrier (BIRD), P. Hantraye (CEA), A. Bachoud-Levi (UPEC)

FINANCEMENT

Repair-HD FP7 project (En cours)

Muticentric intra-cerebral grafting in Huntington’s disease

COORDINATION

AC Bachoud-Lévi (UPEC)

PARTENAIRES

S. Palfi (APHP), P. Remy (UPEC), P. Maison, P. Hantraye (CEA), M. Peschanski (BIRD)

FINANCEMENT

DRCD AP-HP, PHRC 2000, 2004, 2011 (2001–2014)

Hematopoietic stem cell gene therapy in X-linked adrenoleukodystrophy

COORDINATION

P. Aubourg and N. Cartier (Inserm)

PARTENAIRES

M. Cavazzana-Calvo, S Hacein-Bey-Abina, A. Fischer (Necker-Enfants Malades, Paris), C. van Kalle, M. Schmidt, A (DKFZ, Heidelberg)

FINANCEMENT

Inserm, AP-HP, University Paris-Descartes, ELA, AFM, Bluebirdbio (2006 – ongoing)

Hematopoietic stem cell gene therapy with lentiviral vector in RETT syndrome

COORDINATION

N. Cartier, P Aubourg (Inserm)

PARTENAIRES

Eithan Galun (Goldyne Savad Institute of Gene Therapy, Hadassah, Israel)

FINANCEMENT

Inserm, AFM



 

THERAPIE GENIQUE

A phase I/II, Open Labeled, Monocentric gene therapy Study in Children with Metachromatic Leukodystrophy

COORDINATION

P. Aubourg (Inserm)

PARTENAIRES

R. Crystal (Cornell University, USA), Ph.Moullier, L.Hertz-Panier (CEA)

FINANCEMENT

ELA foundation, AP-HP, University Paris Descartes, Inserm (2012– 2016)

Brain gene therapy with AAVrh10 encoding human CYP46A1 in inherited forms of Alzheimer and Tauopathie

COORDINATION

Nathalie Cartier

PARTENAIRES

L. Buée (Inserm U837), O. Laprevote (Fac. Paris-Descartes), B. Delatour, Ch. Duyckaerts, Ph. Hantraye

FINANCEMENT

ANR-Canada, France Alzheimer, Fondation Del Ducca (2010 – 2014)

Targeting therapeutic genes to oligodendrocytes in brain and spinal cord

COORDINATION

C. Sevin, P. Aubourg (Inserm)

PARTENAIRES

M-A Colle (Inserm/INRA)

FINANCEMENT

Fondation Del Ducca  (2011 – 2013)

Gene therapy for Huntington’s disease using LV-CNTF

COORDINATION

G. Bonvento (CEA), AC Bachoud-Lévi (UPEC)

PARTENAIRES

P. Hantraye (CEA), P. Remy (UPEC) and S. Palfi (APHP)

FINANCEMENT

APHP, DRCD 2000 and now submitted to the AFM (2011–2014)

Optimization of intrathecal delivery of various AAV vectors  

COORDINATION

M-A. Colle (INRA)

PARTENAIRES

P. Aubourg (Inserm)

FINANCEMENT

AFM (under evaluation)

PROSAVIN Dopamine gene based treatment for Parkinson's disease

COORDINATION S.Palfi (APHP)
PARTENAIRES CEA/ APHP/ UPEC
FINANCEMENT Oxford Biomedica (2003-2023)

DopaGen

COORDINATION S.Palfi (APHP)
PARTENAIRES Ph. Hantraye (CEA)
FINANCEMENT ANR (2014-2017)




 

MODELES ET BIOMAQUEURS

Assessing neurodegeneration, intracellular viscosity and molecular crowding in vivo using diffusion-weighted and proton/phosphorus NMR spectroscopy

COORDINATION

J. Valette  

PARTENAIRES

 

FINANCEMENT

Eli Lilly  (2009)

Development & characterization of a primate model of periventricular leucomalasia

COORDINATION

F. La Chapelle (Inserm)

PARTENAIRES

P. Gressens (Inserm), L. Hertz-Pannier (CEA)

FINANCEMENT

INSERM-CEA  (2009-2015)

Imaging CNS demyelination and remyelination in Multiple Sclerosis using PET

COORDINATION

Bruno Stankoff (IHU-A-ICM)

PARTENAIRES

M. Bottlaender (CEA) 

FINANCEMENT

ELA, INSERM-DHOS, FRM, JNLF (2009-2012)

Microglial activation in Parkinson’s Disease

COORDINATION

P. Rémy (UPEC)

PARTENAIRES

P. Rémy  P. Hantraye (CEA), M. Vidailhet & A. Brice (IHU)

FINANCEMENT

France-Parkinson (2011–2013)

HDeNERGY : Validation of molecular neuroimaging biomarkers in Huntington's disease in view of therapeutic trials targeting the Krebs cycle

COORDINATION

E. Brouillet (CEA)

PARTENAIRES

F. Mochel (IHU-A-ICM)

FINANCEMENT

ANR (2015-2018)

PRIMA-TAU. A primate model of tauopathies  

COORDINATION

P.Hantraye (CEA)

PARTENAIRES

Luc Buee (Inserm, Lille)

FINANCEMENT

Fondation Plan Alzheimer (2011-2013)

A primate model of Huntington’s disease and the assessment of Si-RNA therapy  

COORDINATION

N. Deglon (CHUV, Lausanne, Switzerland)

PARTENAIRES

I2BM ET UPEC

FINANCEMENT

CEA/CHUV

ASTROinAD : Towards a gene therapy targeting astrocytes in AD

COORDINATION G. Bonvento (CEA)
PARTENAIRES Bruno Cauli (IHU-A-ICM), Stéphane Oliet (Inserm U682)
FINANCEMENT Association France Alzheimer- Fondation de France

LRRK2 : Etude de la neurotoxicité des domaines fonctionnels de LRRK2 par vectorisation virale : vers de nouveaux modèles génétiques chez le rat et le primate non humain

COORDINATION

E. Brouillet (CEA)
PARTENAIRES  
FINANCEMENT Fondation de France (2011-2013)

LRRK2 and alpha-synucléine : Fonctionnal interaction between LRRK2 and in vivo alpha-synucléine

COORDINATION E. Brouillet (CEA)
PARTENAIRES  
FINANCEMENT Fondation de France (2012-2016)

Inductibility of amyloidosis and Tau pathologies in Alzheimer's disease : Feasability ans mechanisms of action in a non human primate model

COORDINATION M. Dhenain (CEA)
PARTENAIRES F. Pifferi, UMR 8571 Brunoy
FINANCEMENT France-Alzheimer (2012-2015)

New tools for the diagnosis of Alzheimer's disease : LLAMA VHH antibody fragments targeting amyloid plaques and neurofibrillary lesions (LLAMALZ)

COORDINATION P. Lafaye (Institut Pasteur)
PARTENAIRES M. Dhenain (CEA), B. Delatour (IHU), S; Bay (Institut Pasteur)
FINANCEMENT Institut Roche de Rechecrhe et Médecine Translationnelle (2011-2014)


 

THERAPIES MEDICAMENTEUSES

Nucleipark

COORDINATION

M. Vidailhet (IHU) & C. Poupon (CEA)

PARTENAIRES

CEA, APHP, INSERM, INRIA

FINANCEMENT

ANR, ENP, France Parkinson, APHP, INSERM

LRRK2 prospective cohort: identifying pre-symptomatic markers in Parkinson’s

COORDINATION

A Brice (IHU)

PARTENAIRES

P. Remy (UPEC), P. Hantraye (CEA), MJFF, AP-HP

FINANCEMENT

APHP – INSERM - MJFF (2009-2014)- Fondation Avenir

Study of S47445 in a rat model of Huntington's disease  

COORDINATION

E. Brouillet (CEA)

PARTENAIRES

 

FINANCEMENT

 Servier (2012-2014)

SCREENTOX:Stem Cells for Replicable Efficient Extended and Normalized Toxicology 

COORDINATION

M. Peschanski 

PARTENAIRES

European Network (13 partners in 5 countries)

FINANCEMENT

EC (2011-2015)

Study of S47445 in a primate model of Huntington's disease 

COORDINATION

R. Aron Badin (CEA)

PARTENAIRES

 

FINANCEMENT

Servier (2012-2013)



 

PEDIATRIE

The blood brain barrier in perinatal brain damage

COORDINATION

P. Gressens  

PARTENAIRES

Inserm

FINANCEMENT

FP7 (2010 – 2013), Leducq Foundation (2010-2014)

Rare infantile epilepsies: use of clinical trial simulation for the choice and optimization of study design

COORDINATION

C. Chiron 

PARTENAIRES

G. Pons, V. Jullien (U663)

FINANCEMENT

ERA-NET PRIOMEDCHILD (2011 – 2013), INSERM & APHP (2011 – 2012)

In vitro study of the human blood brain barrier at pediatric age

COORDINATION

C. Chiron 

PARTENAIRES

G. Pons (U663)

FINANCEMENT

ANR (01/2010 – 12/2012)

Impact du stress foetal sur la santé mentale : les facteurs HSF (Heat Shck Fcators), médiateurs d'événements épigénétiques

COORDINATION V. Mezger (CNRS)
PARTENAIRES P. Gressens (Inserm UMR1141), J. Gallego (Inserm UMR1141)
FINANCEMENT ANR Samenta (2014-2016)

Validate an immunoassay based on electro-chemo-luminescence to measure cytokine levels in human plasma in indviduals with psychiatric disorders

COORDINATION N. Glaichenhaus (Universite de Nice Sophia Antipolis)
PARTENAIRES P. Gressens (Inserm UMR1141), R. Belzaux (APHM), M. Leboyer (Inserm UMR955)
FINANCEMENT Projet incitatif immuno-psychiatrie ITMO IHP (2014)

Role of microglial metabolism in perinatal inflammation

COORDINATION P. Gressens (Inserm UMR1141)
PARTENAIRES P. Carmeliet (KUL, Leuven, Belgique), C. Verderio(CNR, Milan, Italie), H. Hagberg (University of Göteborg, Suède)
FINANCEMENT ERA-NET Neuron (2015-2017)

Rôle de l'inflammation périnatale dans la physiopathologie des troubles du spectre autistique

COORDINATION P. Gressens (Inserm UMR1141)
PARTENAIRES R. Delorme (APHP)
FINANCEMENT Fondation de France (2015-2016)