Regulators neurons sleep-wake rhythms involved in Parkinson's disease

A new discovery from the team of Pr. Etienne C.Hirsch at the ICM highlights the protective role of new neurons in Parkinson's disease. This study suggests a promising new therapeutic approach for this disease.


April 11th : World Parkinson's disease day

In the context of World Parkinson’s disease day on April 11th, the ICM focuses on the latest discoveries.

Parkinson’s disease is the most common neurodegenerative disease after Alzheimer’s. Second cause of motor disability with 4 million people in the world, Parkinson’s disease is characterised by the death of a population of neurons, called dopaminergic. These neurons produce a substance, dopamine, playing a role in the transmission of information between neurons, and essential to the harmonious control of movements. Symptoms include slow movements, stiffness of the limbs and chest, tremor, and walking ability disorders. These motor symptoms can lead to disability and loss of total autonomy in the person suffering from this disease.

Drug treatments can reduce the symptoms of the disease, by using dopamine agonists. However, there is no treatment to slow the progression of the disease; we can’t prevent neuronal death. Moreover, this neuronal degeneration is unfortunately not limited to dopaminergic neurons, nor to the motor system.

What are the risk factors of the disease ? What are the mechanisms responsible for the loss of neurons ? And how to counter them in order to slow the progression of the disease ? Researchers and clinicians take advantage of the ICM premises and its cutting-edge technology platforms to answer these questions and fight the disease.

Alzheimer’s disease: a study sponsored by AP-HP identifies early protective role of the immune system

For the first time in humans, an imaging study shows early and protective role of immune cells in the brain, called "microglia" in Alzheimer's disease. The teams of the CHU Sainte-Anne, the CEA, Saint-Antoine research center, the Institute for Brain and Spinal Cord Disorders (Inserm / CNRS / UPMC) and Roche researchers have identified a benefit of inflammatory mechanisms the early or preclinical stages, in a group of 96 subjects. This discovery opens up new therapeutic approaches to slow or even prevent the progression of Alzheimer's disease. This work, from the IMABio3 study * sponsored by AP-HP, are the subject of a publication on 16 March in the journal Brain.


Brain Awareness week 2015

For the 17th edition of Brain Awareness Week , coordinated by the Society for Neuroscience , CEA- NeuroSpin opens and organizes many meetings with scientists.

Conferences and  visits to discover or deepen your knowledge on the brain.