La conférence NECTAR 2023 aura lieu à Naples, en Italie, du 23 au 25 octobre 2023.

L'objectif de cette conférence est de présenter (1) les avancées récentes dans la modélisation des troubles cérébraux humains et la compréhension des mécanismes moléculaires à l'origine des troubles du système nerveux central, (2) les développements récents en matière de thérapies cellulaires et géniques pour les maladies de Parkinson et de Huntington, (3) les avancées en matière de thérapie génique et de transplantation de cellules pour des pathologies telles que les lésions de la moelle épinière, la sclérose latérale amyotrophique et la perte de vision.

Inscriptions : du 31 mai au 1er septembre 2023.

Plus de détails.

 

En 2022, les travaux de recherche de NeurATRIS ont généré 235 publications dans des journaux à comité de lecture. Un grand merci à toutes nos équipes et collaborateurs, qui oeuvrent chaque jour à faire progresser la recherche translationnelle en neurosciences!

 

  • Alcalá-Vida, Rafael, Caroline Lotz, Baptiste Brulé, Jonathan Seguin, Charles Decraene, Ali Awada, Aurélie Bombardier, et al. « Altered Activity-Regulated H3K9 Acetylation at TGF-Beta Signaling Genes during Egocentric Memory in Huntington’s Disease ». Progress in Neurobiology 219 (décembre 2022): 102363. https://doi.org/10.1016/j.pneurobio.2022.102363.
  • Alonso-Alconada, Daniel, Pierre Gressens, Xavier Golay, et Nicola J. Robertson. « Neurogenesis Is Reduced at 48 h in the Subventricular Zone Independent of Cell Death in a Piglet Model of Perinatal Hypoxia-Ischemia ». Frontiers in Pediatrics 10 (2022): 793189. https://doi.org/10.3389/fped.2022.793189.
  • Androuin, Alexandre, Manon Thierry, Susana Boluda, Brainbank NeuroCEB Neuropathology Network, Asha Baskaran, Dominique Langui, Charles Duyckaerts, et al. « Alterations of Neuronal Lysosomes in Alzheimer’s Disease and in APPxPS1-KI Mice ». Journal of Alzheimer’s Disease: JAD 87, no 1 (2022): 273‑84. https://doi.org/10.3233/JAD-215692.
  • Audouard, Emilie, Fanny Michel, Vanessa Pierroz, Taeuk Kim, Lisa Rousselot, Béatrix Gillet-Legrand, Gaëlle Dufayet-Chauffaut, et al. « Bioelectronic Cell-Based Device Provides a Strategy for the Treatment of the Experimental Model of Multiple Sclerosis ». Journal of Controlled Release: Official Journal of the Controlled Release Society 352 (décembre 2022): 994‑1008. https://doi.org/10.1016/j.jconrel.2022.11.008.
  • Bachoud-Lévi, A.-C. « What Did We Learn from Neural Grafts in Huntington Disease? » Revue Neurologique 178, no 5 (mai 2022): 441‑49. https://doi.org/10.1016/j.neurol.2022.03.004.
  • Bachoud-Lévi, Anne-Catherine, Alice Dormeuil, et Charlotte Jacquemot. « Improving Efficacy of Aphasia Rehabilitation by Using Core Assessment of Language Processing ». Annals of Physical and Rehabilitation Medicine 65, no 6 (novembre 2022): 101630. https://doi.org/10.1016/j.rehab.2022.101630.
  • Bacq, Alexandre, Delphine Roussel, Thomas Bonduelle, Sara Zagaglia, Marina Maletic, Théo Ribierre, Homa Adle-Biassette, et al. « Cardiac Investigations in Sudden Unexpected Death in DEPDC5-Related Epilepsy ». Annals of Neurology 91, no 1 (janvier 2022): 101‑16. https://doi.org/10.1002/ana.26256.
  • Balsiger, Fabian, Benedikt Wagner, Johann M. E. Jende, Benjamin Marty, Martin Bendszus, Olivier Scheidegger, et Felix T. Kurz. « Methodologies and MR Parameters in Quantitative Magnetic Resonance Neurography: A Scoping Review Protocol ». Methods and Protocols 5, no 3 (6 mai 2022): 39. https://doi.org/10.3390/mps5030039.
  • Barbier, Mathieu, Melanie Bahlo, Alessandra Pennisi, Maxime Jacoupy, Rick M. Tankard, Claire Ewenczyk, Kayli C. Davies, et al. « Heterozygous PNPT1 Variants Cause Spinocerebellar Ataxia Type 25 ». Annals of Neurology 92, no 1 (juillet 2022): 122‑37. https://doi.org/10.1002/ana.26366.
  • Barros, L. F., I. Ruminot, T. Sotelo-Hitschfeld, R. Lerchundi, et I. Fernández-Moncada. « Metabolic Recruitment in Brain Tissue ». Annual Review of Physiology, 21 octobre 2022. https://doi.org/10.1146/annurev-physiol-021422-091035.
  • Bassignana, Giulia, Giordano Lacidogna, Paolo Bartolomeo, Olivier Colliot, et Fabrizio De Vico Fallani. « The Impact of Aging on Human Brain Network Target Controllability ». Brain Structure & Function 227, no 9 (décembre 2022): 3001‑15. https://doi.org/10.1007/s00429-022-02584-w.
  • Bayen, Eléonore, Laurent Cleret de Langavant, Katia Youssov, et Anne-Catherine Bachoud-Lévi. « Informal Care in Huntington’s Disease: Assessment of Objective-Subjective Burden and Its Associated Risk and Protective Factors ». Annals of Physical and Rehabilitation Medicine 66, no 4 (2 décembre 2022): 101703. https://doi.org/10.1016/j.rehab.2022.101703.
  • Beaudin, Marie, François Salachas, Pierre-François Pradat, et Nicolas Dupré. « Environmental Risk Factors for Amyotrophic Lateral Sclerosis: A Case-Control Study in Canada and France ». Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration 23, no 7‑8 (novembre 2022): 592‑600. https://doi.org/10.1080/21678421.2022.2028167.
  • Bellenguez, Céline, Fahri Küçükali, Iris E. Jansen, Luca Kleineidam, Sonia Moreno-Grau, Najaf Amin, Adam C. Naj, et al. « New Insights into the Genetic Etiology of Alzheimer’s Disease and Related Dementias ». Nature Genetics 54, no 4 (avril 2022): 412‑36. https://doi.org/10.1038/s41588-022-01024-z.
  • Ben Haim, Lucile, et Carole Escartin. « Astrocytes and Neuropsychiatric Symptoms in Neurodegenerative Diseases: Exploring the Missing Links ». Current Opinion in Neurobiology 72 (février 2022): 63‑71. https://doi.org/10.1016/j.conb.2021.09.002.
  • Benardais, Karelle, Isis M. Ornelas, Melissa Fauveau, Tanya L. Brown, Lisbet T. Finseth, Radmila Panic, Cyrille Deboux, Wendy B. Macklin, Teresa L. Wood, et Brahim Nait-Oumesmar. « P70S6 Kinase Regulates Oligodendrocyte Differentiation and Is Active in Remyelinating Lesions ». Brain Communications 4, no 1 (2022): fcac025. https://doi.org/10.1093/braincomms/fcac025.
  • Benatar, Michael, Joanne Wuu, Caroline McHutchison, Ronald B. Postuma, Bradley F. Boeve, Ronald Petersen, Christopher A. Ross, et al. « Preventing Amyotrophic Lateral Sclerosis: Insights from Pre-Symptomatic Neurodegenerative Diseases ». Brain: A Journal of Neurology 145, no 1 (29 mars 2022): 27‑44. https://doi.org/10.1093/brain/awab404.
  • Betrouni, Nacim, Caroline Moreau, Anne-Sophie Rolland, Nicolas Carrière, Romain Viard, Renaud Lopes, Gregory Kuchcinski, et al. « Can Dopamine Responsiveness Be Predicted in Parkinson’s Disease Without an Acute Administration Test? » Journal of Parkinson’s Disease 12, no 7 (2022): 2179‑90. https://doi.org/10.3233/JPD-223334.
  • Bigarreau, Julie, Nathalie Rouach, Anselme L. Perrier, Franck Mouthon, et Mathieu Charvériat. « Modeling and Targeting Neuroglial Interactions with Human Pluripotent Stem Cell Models ». International Journal of Molecular Sciences 23, no 3 (31 janvier 2022): 1684. https://doi.org/10.3390/ijms23031684.
  • Blanc, Frederic, Vincent Bouteloup, Claire Paquet, Marie Chupin, Florence Pasquier, Audrey Gabelle, Mathieu Ceccaldi, et al. « Prodromal Characteristics of Dementia with Lewy Bodies: Baseline Results of the MEMENTO Memory Clinics Nationwide Cohort ». Alzheimer’s Research & Therapy 14, no 1 (19 juillet 2022): 96. https://doi.org/10.1186/s13195-022-01037-0.
  • Bloms-Funke, Petra, Michael Schumacher, Song Liu, Diya Su, Jing Li, Philippe Liere, Rainer Rupprecht, et al. « A Novel Dual Mode-of-Action Anti-Hyperalgesic Compound in Rats Which Is Neuroprotective and Promotes Neuroregeneration ». European Journal of Pharmacology 923 (15 mai 2022): 174935. https://doi.org/10.1016/j.ejphar.2022.174935.
  • Bokobza, Cindy, Alice Jacquens, David Guenoun, Blandine Bianco, Anne Galland, Maxime Pispisa, Alexandra Cruz, et al. « Targeting the Brain 5-HT7 Receptor to Prevent Hypomyelination in a Rodent Model of Perinatal White Matter Injuries ». Journal of Neural Transmission (Vienna, Austria: 1996), 6 novembre 2022. https://doi.org/10.1007/s00702-022-02556-8.
  • Bokobza, Cindy, Alice Jacquens, Manuela Zinni, Valérie Faivre, Jennifer Hua, David Guenoun, Caroline Userovici, et al. « Magnetic Isolation of Microglial Cells from Neonate Mouse for Primary Cell Cultures ». Journal of Visualized Experiments: JoVE, no 185 (25 juillet 2022). https://doi.org/10.3791/62964.
  • Bokobza, Cindy, Pooja Joshi, Anne-Laure Schang, Zsolt Csaba, Valérie Faivre, Amélie Montané, Anne Galland, et al. « MiR-146b Protects the Perinatal Brain against Microglia-Induced Hypomyelination ». Annals of Neurology 91, no 1 (janvier 2022): 48‑65. https://doi.org/10.1002/ana.26263.
  • Bonvento, Gilles, Stéphane H. R. Oliet, et Aude Panatier. « Glycolysis-Derived L-Serine Levels versus PHGDH Expression in Alzheimer’s Disease ». Cell Metabolism 34, no 5 (3 mai 2022): 654‑55. https://doi.org/10.1016/j.cmet.2022.04.002.
  • Bossi, Simon, Dhanasak Dhanasobhon, Graham C. R. Ellis-Davies, Jimena Frontera, Marcel de Brito Van Velze, Joana Lourenço, Alvaro Murillo, et al. « GluN3A Excitatory Glycine Receptors Control Adult Cortical and Amygdalar Circuits ». Neuron 110, no 15 (3 août 2022): 2438-2454.e8. https://doi.org/10.1016/j.neuron.2022.05.016.
  • Bourdon, Audrey, Virginie François, Liwen Zhang, Aude Lafoux, Bodvael Fraysse, Gilles Toumaniantz, Thibaut Larcher, et al. « Evaluation of the Dystrophin Carboxy-Terminal Domain for Micro-Dystrophin Gene Therapy in Cardiac and Skeletal Muscles in the DMDmdx Rat Model ». Gene Therapy 29, no 9 (septembre 2022): 520‑35. https://doi.org/10.1038/s41434-022-00317-6.
  • Boussac, Mathilde, Christophe Arbus, Olivier Colin, Chloé Laurencin, Alexandre Eusebio, Elodie Hainque, Jean Christophe Corvol, et al. « Personality Assessment with Temperament and Character Inventory in Parkinson’s Disease ». Parkinsonism & Related Disorders 103 (octobre 2022): 34‑41. https://doi.org/10.1016/j.parkreldis.2022.08.004.
  • Boutros, Celina F., Walaa Khazaal, Maram Taliani, Najwane Said Sadier, Pascale Salameh, et Hassan Hosseini. « One-Year Recurrence of Stroke and Death in Lebanese Survivors of First-Ever Stroke: Time-to-Event Analysis ». Frontiers in Neurology 13 (2022): 973200. https://doi.org/10.3389/fneur.2022.973200.
  • Bouzigues, Arabella, Lucy L. Russell, Georgia Peakman, Martina Bocchetta, Caroline V. Greaves, Rhian S. Convery, Emily Todd, et al. « Anomia Is Present Pre-Symptomatically in Frontotemporal Dementia Due to MAPT Mutations ». Journal of Neurology 269, no 8 (août 2022): 4322‑32. https://doi.org/10.1007/s00415-022-11068-0.
  • Boyer, Manon, Paul Baudin, Chloé Stengel, Antoni Valero-Cabré, Ann M. Lohof, Stéphane Charpier, Rachel M. Sherrard, et Séverine Mahon. « In Vivo Low-Intensity Magnetic Pulses Durably Alter Neocortical Neuron Excitability and Spontaneous Activity ». The Journal of Physiology 600, no 17 (septembre 2022): 4019‑37. https://doi.org/10.1113/JP283244.
  • Brašić, James Robert, Jack Alexander Goodman, Ayon Nandi, David S. Russell, Danna Jennings, Olivier Barret, Samuel D. Martin, et al. « Fragile X Mental Retardation Protein and Cerebral Expression of Metabotropic Glutamate Receptor Subtype 5 in Men with Fragile X Syndrome: A Pilot Study ». Brain Sciences 12, no 3 (26 février 2022): 314. https://doi.org/10.3390/brainsci12030314.
  • Brouillet, Emmanuel. « Extreme Conservation of the Poly-Glutamine Tract in Huntingtin Is Related to Neurodevelopmental Functions: The “Better” May Become the “Enemy of the Good” in the Course of Evolution ». Cell Death and Differentiation 29, no 2 (février 2022): 266‑68. https://doi.org/10.1038/s41418-021-00927-4.
  • Burbidge, Kevin, David J. Rademacher, Jessica Mattick, Stephanie Zack, Andrea Grillini, Luc Bousset, Ochan Kwon, et al. « LGALS3 (Galectin 3) Mediates an Unconventional Secretion of SNCA/α-Synuclein in Response to Lysosomal Membrane Damage by the Autophagic-Lysosomal Pathway in Human Midbrain Dopamine Neurons ». Autophagy 18, no 5 (mai 2022): 1020‑48. https://doi.org/10.1080/15548627.2021.1967615.
  • Cacciamani, Federica, Valérie Godefroy, Simona M. Brambati, Raffaella Migliaccio, Stéphane Epelbaum, et Maxime Montembeault. « Differential Patterns of Domain-Specific Cognitive Complaints and Awareness Across the Alzheimer’s Disease Spectrum ». Frontiers in Aging Neuroscience 14 (2022): 811739. https://doi.org/10.3389/fnagi.2022.811739.
  • Canonico, Marianne, Fanny Artaud, Isabelle Degaey, Frédéric Moisan, Rahime Kabore, Berta Portugal, Thi Thu Ha Nguyen, et al. « Incidence of Parkinson’s Disease in French Women from the E3N Cohort Study over 27 Years of Follow-Up ». European Journal of Epidemiology 37, no 5 (mai 2022): 513‑23. https://doi.org/10.1007/s10654-022-00851-y.
  • Chandrasekaran, Jayashree, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Dinesh K. Deelchand, Michal Považan, et al. « Clinically Meaningful Magnetic Resonance Endpoints Sensitive to Preataxic Spinocerebellar Ataxia Types 1 and 3 ». Annals of Neurology, 13 décembre 2022. https://doi.org/10.1002/ana.26573.
  • Charrier, Marine, Judith Lorant, Rafael Contreras-Lopez, Gautier Téjédor, Christophe Blanquart, Blandine Lieubeau, Cindy Schleder, et al. « Human MuStem Cells Repress T-Cell Proliferation and Cytotoxicity through Both Paracrine and Contact-Dependent Pathways ». Stem Cell Research & Therapy 13, no 1 (10 janvier 2022): 7. https://doi.org/10.1186/s13287-021-02681-3.
  • Chou, Qiao-Ling, Ania Alik, François Marquier, Ronald Melki, François Treussart, et Michel Simonneau. « Impact of α-Synuclein Fibrillar Strains and β-Amyloid Assemblies on Mouse Cortical Neurons Endo-Lysosomal Logistics ». ENeuro 9, no 3 (2022): ENEURO.0227-21.2022. https://doi.org/10.1523/ENEURO.0227-21.2022.
  • Chougar, Lydia, Emina Arsovic, Rahul Gaurav, Emma Biondetti, Alice Faucher, Romain Valabrègue, Nadya Pyatigorskaya, et al. « Regional Selectivity of Neuromelanin Changes in the Substantia Nigra in Atypical Parkinsonism ». Movement Disorders: Official Journal of the Movement Disorder Society 37, no 6 (juin 2022): 1245‑55. https://doi.org/10.1002/mds.28988.
  • Cleret de Langavant, Laurent, Emmanuel Roze, Aimée Petit, Benoit Tressières, Amin Gharbi-Meliani, Hugo Chaumont, Patrick Pierre Michel, et al. « Annonaceae Consumption Worsens Disease Severity and Cognitive Deficits in Degenerative Parkinsonism ». Movement Disorders: Official Journal of the Movement Disorder Society 37, no 12 (décembre 2022): 2355‑66. https://doi.org/10.1002/mds.29222.
  • Cortese, Rosa, Marco Battaglini, Ferran Prados, Alessia Bianchi, Lukas Haider, Anu Jacob, Jacqueline Palace, et al. « Clinical and MRI Measures to Identify Non-Acute MOG-Antibody Disease in Adults ». Brain: A Journal of Neurology, 14 décembre 2022, awac480. https://doi.org/10.1093/brain/awac480.
  • Dadgar-Kiani, Ehsan, Gregor Bieri, Ronald Melki, Aaron D. Gitler, et Jin Hyung Lee. « Mesoscale Connections and Gene Expression Empower Whole-Brain Modeling of α-Synuclein Spread, Aggregation, and Decay Dynamics ». Cell Reports 41, no 6 (8 novembre 2022): 111631. https://doi.org/10.1016/j.celrep.2022.111631.
  • Daly, Timothy, Ignacio Mastroleo, et Raffaella Migliaccio. « Avoiding Over-Reliance on Multi-Domain Interventions for Dementia Prevention ». Journal of Alzheimer’s Disease: JAD 90, no 3 (2022): 989‑92. https://doi.org/10.3233/JAD-215647.
  • De Cock, Valérie Cochen, Pauline Dodet, Smaranda Leu-Semenescu, Cécile Aerts, Giovanni Castelnovo, Beatriz Abril, Sophie Drapier, et al. « Safety and Efficacy of Subcutaneous Night-Time Only Apomorphine Infusion to Treat Insomnia in Patients with Parkinson’s Disease (APOMORPHEE): A Multicentre, Randomised, Controlled, Double-Blind Crossover Study ». The Lancet. Neurology 21, no 5 (mai 2022): 428‑37. https://doi.org/10.1016/S1474-4422(22)00085-0.
  • De Giorgi, Francesca, Muhammed Bilal Abdul-Shukkoor, Marianna Kashyrina, Leslie-Ann Largitte, Francesco De Nuccio, Brice Kauffmann, Alons Lends, et al. « Neurons with Cat’s Eyes: A Synthetic Strain of α-Synuclein Fibrils Seeding Neuronal Intranuclear Inclusions ». Biomolecules 12, no 3 (11 mars 2022): 436. https://doi.org/10.3390/biom12030436.
  • De Nicola, Alejandro F., María Meyer, Laura Garay, Maria Sol Kruse, Michael Schumacher, Rachida Guennoun, et Maria Claudia Gonzalez Deniselle. « Progesterone and Allopregnanolone Neuroprotective Effects in the Wobbler Mouse Model of Amyotrophic Lateral Sclerosis ». Cellular and Molecular Neurobiology 42, no 1 (janvier 2022): 23‑40. https://doi.org/10.1007/s10571-021-01118-y.
  • Degos, Bertrand, Pierre Pouget, et Marcus Missal. « From Anticipation to Impulsivity in Parkinson’s Disease ». NPJ Parkinson’s Disease 8, no 1 (3 octobre 2022): 125. https://doi.org/10.1038/s41531-022-00393-w.
  • Deuschl, Günther, Angelo Antonini, Joao Costa, Katarzyna Śmiłowska, Daniela Berg, Jean-Christophe Corvol, Giovanni Fabbrini, et al. « European Academy of Neurology/Movement Disorder Society-European Section Guideline on the Treatment of Parkinson’s Disease: I. Invasive Therapies ». Movement Disorders: Official Journal of the Movement Disorder Society 37, no 7 (juillet 2022): 1360‑74. https://doi.org/10.1002/mds.29066.
  • Devos, David, Julien Labreuche, Olivier Rascol, Jean-Christophe Corvol, Alain Duhamel, Pauline Guyon Delannoy, Werner Poewe, et al. « Trial of Deferiprone in Parkinson’s Disease ». The New England Journal of Medicine 387, no 22 (1 décembre 2022): 2045‑55. https://doi.org/10.1056/NEJMoa2209254.
  • Diaz Heijtz, Rochellys, Pierre Gressens, et Jonathan R. Swann. « Targeting Microbial Metabolites to Treat Autism ». Nature Medicine 28, no 3 (mars 2022): 448‑50. https://doi.org/10.1038/s41591-022-01711-8.
  • Dietrich, Michael, Christina Hecker, Elodie Martin, Dominique Langui, Michael Gliem, Bruno Stankoff, Catherine Lubetzki, et al. « Increased Remyelination and Proregenerative Microglia Under Siponimod Therapy in Mechanistic Models ». Neurology(R) Neuroimmunology & Neuroinflammation 9, no 3 (mai 2022): e1161. https://doi.org/10.1212/NXI.0000000000001161.
  • Doan Ngoc, Tra-My, Gaëlle Tilly, Richard Danger, Orianne Bonizec, Christophe Masset, Pierrick Guérif, Sarah Bruneau, et al. « Effector Memory-Expressing CD45RA (TEMRA) CD8+ T Cells from Kidney Transplant Recipients Exhibit Enhanced Purinergic P2X4 Receptor-Dependent Proinflammatory and Migratory Responses ». Journal of the American Society of Nephrology: JASN 33, no 12 (décembre 2022): 2211‑31. https://doi.org/10.1681/ASN.2022030286.
  • Domenighetti, Cloé, Venceslas Douillard, Pierre-Emmanuel Sugier, Ashwin Ashok Kumar Sreelatha, Claudia Schulte, Sandeep Grover, Patrick May, et al. « The Interaction between HLA-DRB1 and Smoking in Parkinson’s Disease Revisited ». Movement Disorders: Official Journal of the Movement Disorder Society 37, no 9 (septembre 2022): 1929‑37. https://doi.org/10.1002/mds.29133.
  • Domenighetti, Cloé, Pierre-Emmanuel Sugier, Ashwin Ashok Kumar Sreelatha, Claudia Schulte, Sandeep Grover, Océane Mohamed, Berta Portugal, et al. « Dairy Intake and Parkinson’s Disease: A Mendelian Randomization Study ». Movement Disorders: Official Journal of the Movement Disorder Society 37, no 4 (avril 2022): 857‑64. https://doi.org/10.1002/mds.28902.
  • Dos Santos Pereira, Maurício, Glauce Crivelaro do Nascimento, Mariza Bortolanza, Patrick Pierre Michel, Rita Raisman-Vozari, et Elaine Del Bel. « Doxycycline Attenuates L-DOPA-Induced Dyskinesia through an Anti-Inflammatory Effect in a Hemiparkinsonian Mouse Model ». Frontiers in Pharmacology 13 (2022): 1045465. https://doi.org/10.3389/fphar.2022.1045465.
  • Douceau, Sara, Eloïse Lemarchand, Yannick Hommet, Laurent Lebouvier, Charlène Joséphine, Alexis-Pierre Bemelmans, Eric Maubert, Véronique Agin, et Denis Vivien. « PKCδ-Positive GABAergic Neurons in the Central Amygdala Exhibit Tissue-Type Plasminogen Activator: Role in the Control of Anxiety ». Molecular Psychiatry 27, no 4 (avril 2022): 2197‑2205. https://doi.org/10.1038/s41380-022-01455-4.
  • Dubreil, Laurence, Mireille Ledevin, Caroline Hervet, Déborah Menard, Claire Philippe, François J. Michel, Thibaut Larcher, François Meurens, et Nicolas Bertho. « The Internal Conduit System of the Swine Inverted Lymph Node ». Frontiers in Immunology 13 (2022): 869384. https://doi.org/10.3389/fimmu.2022.869384.
  • Egbebike, Jennifer, Qi Shen, Kevin Doyle, Caroline A. Der-Nigoghossian, Lucy Panicker, Ian Jerome Gonzales, Lauren Grobois, et al. « Cognitive-Motor Dissociation and Time to Functional Recovery in Patients with Acute Brain Injury in the USA: A Prospective Observational Cohort Study ». The Lancet. Neurology 21, no 8 (août 2022): 704‑13. https://doi.org/10.1016/S1474-4422(22)00212-5.
  • Ellul, Pierre, Eric Acquaviva, Hugo Peyre, Michelle Rosenzwajg, Pierre Gressens, David Klatzmann, et Richard Delorme. « Parental Autoimmune and Autoinflammatory Disorders as Multiple Risk Factors for Common Neurodevelopmental Disorders in Offspring: A Systematic Review and Meta-Analysis ». Translational Psychiatry 12, no 1 (18 mars 2022): 112. https://doi.org/10.1038/s41398-022-01843-y.
  • Epelbaum, Stéphane, Ninon Burgos, Michael Canney, Dawn Matthews, Marion Houot, Mathieu D. Santin, Carole Desseaux, et al. « Pilot Study of Repeated Blood-Brain Barrier Disruption in Patients with Mild Alzheimer’s Disease with an Implantable Ultrasound Device ». Alzheimer’s Research & Therapy 14, no 1 (8 mars 2022): 40. https://doi.org/10.1186/s13195-022-00981-1.
  • Faouzi, Johann, Samir Bekadar, Fanny Artaud, Alexis Elbaz, Graziella Mangone, Olivier Colliot, et Jean-Christophe Corvol. « Machine Learning-Based Prediction of Impulse Control Disorders in Parkinson’s Disease From Clinical and Genetic Data ». IEEE Open Journal of Engineering in Medicine and Biology 3 (2022): 96‑107. https://doi.org/10.1109/OJEMB.2022.3178295.
  • Farcy, Sarah, Alexandra Albert, Pierre Gressens, Alexandre D. Baffet, et Vincent El Ghouzzi. « Cortical Organoids to Model Microcephaly ». Cells 11, no 14 (7 juillet 2022): 2135. https://doi.org/10.3390/cells11142135.
  • Farooq, Muhammad, Mélanie Simoes Eugénio, Claire Piquet-Pellorce, Sarah Dion, Céline Raguenes-Nicol, Kathleen Santamaria, Ghania Hounana Kara-Ali, et al. « Receptor-Interacting Protein Kinase-1 Ablation in Liver Parenchymal Cells Promotes Liver Fibrosis in Murine NASH without Affecting Other Symptoms ». Journal of Molecular Medicine (Berlin, Germany) 100, no 7 (juillet 2022): 1027‑38. https://doi.org/10.1007/s00109-022-02192-5.
  • Favrais, Geraldine, Cindy Bokobza, Elie Saliba, Sylvie Chalon, et Pierre Gressens. « Alteration of the Oligodendrocyte Lineage Varies According to the Systemic Inflammatory Stimulus in Animal Models That Mimic the Encephalopathy of Prematurity ». Frontiers in Physiology 13 (2022): 881674. https://doi.org/10.3389/fphys.2022.881674.
  • Festari, Cristina, Federico Massa, Matteo Cotta Ramusino, Federica Gandolfo, Valentina Nicolosi, Stefania Orini, Dag Aarsland, et al. « European Consensus for the Diagnosis of MCI and Mild Dementia: Preparatory Phase ». Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, 9 octobre 2022. https://doi.org/10.1002/alz.12798.
  • Fevga, Christina, Christelle Tesson, Ana Carreras Mascaro, Thomas Courtin, Riaan van Coller, Salma Sakka, Federico Ferraro, et al. « PTPA Variants and Impaired PP2A Activity in Early-Onset Parkinsonism with Intellectual Disability ». Brain: A Journal of Neurology, 8 septembre 2022, awac326. https://doi.org/10.1093/brain/awac326.
  • Finger, Elizabeth, Rubina Malik, Martina Bocchetta, Kristy Coleman, Caroline Graff, Barbara Borroni, Mario Masellis, et al. « Neurodevelopmental Effects of Genetic Frontotemporal Dementia in Young Adult Mutation Carriers ». Brain: A Journal of Neurology, 2 décembre 2022, awac446. https://doi.org/10.1093/brain/awac446.
  • Foster, Phoebe H., Lucy L. Russell, Georgia Peakman, Rhian S. Convery, Arabella Bouzigues, Caroline V. Greaves, Martina Bocchetta, et al. « Examining Empathy Deficits across Familial Forms of Frontotemporal Dementia within the GENFI Cohort ». Cortex; a Journal Devoted to the Study of the Nervous System and Behavior 150 (mai 2022): 12‑28. https://doi.org/10.1016/j.cortex.2022.01.012.
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  • Weiss, Daniel, Zied Landoulsi, Patrick May, Manu Sharma, Michael Schüpbach, Hana You, Jean Christophe Corvol, et al. « Genetic Stratification of Motor and QoL Outcomes in Parkinson’s Disease in the EARLYSTIM Study ». Parkinsonism & Related Disorders 103 (octobre 2022): 169‑74. https://doi.org/10.1016/j.parkreldis.2022.08.025.
  • Whiteside, David J., Maura Malpetti, P. Simon Jones, Boyd C. P. Ghosh, Ian Coyle-Gilchrist, John C. van Swieten, Harro Seelaar, et al. « Temporal Dynamics Predict Symptom Onset and Cognitive Decline in Familial Frontotemporal Dementia ». Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, 15 novembre 2022. https://doi.org/10.1002/alz.12824.
  • Willacker, L., T. M. Raiser, M. Bassi, A. Bender, A. Comanducci, M. Rosanova, N. Sobel, et al. « PerBrain: A Multimodal Approach to Personalized Tracking of Evolving State-of-Consciousness in Brain-Injured Patients: Protocol of an International, Multicentric, Observational Study ». BMC Neurology 22, no 1 (9 décembre 2022): 468. https://doi.org/10.1186/s12883-022-02958-x.
  • Wilson, Katherine M., Eszter Katona, Idoia Glaria, Mireia Carcolé, Imogen J. Swift, Aitana Sogorb-Esteve, Carolin Heller, et al. « Development of a Sensitive Trial-Ready Poly(GP) CSF Biomarker Assay for C9orf72-Associated Frontotemporal Dementia and Amyotrophic Lateral Sclerosis ». Journal of Neurology, Neurosurgery, and Psychiatry 93, no 7 (juillet 2022): 761‑71. https://doi.org/10.1136/jnnp-2021-328710.
  • Woollacott, Ione O. C., Imogen J. Swift, Aitana Sogorb-Esteve, Carolin Heller, Kathryn Knowles, Arabella Bouzigues, Lucy L. Russell, et al. « CSF Glial Markers Are Elevated in a Subset of Patients with Genetic Frontotemporal Dementia ». Annals of Clinical and Translational Neurology 9, no 11 (novembre 2022): 1764‑77. https://doi.org/10.1002/acn3.51672.
  • Wu, Huaqian, Nicolas Souedet, Caroline Jan, Cédric Clouchoux, et Thierry Delzescaux. « A General Deep Learning Framework for Neuron Instance Segmentation Based on Efficient UNet and Morphological Post-Processing ». Computers in Biology and Medicine 150 (4 octobre 2022): 106180. https://doi.org/10.1016/j.compbiomed.2022.106180.
  • Xicota, Laura, Beata Gyorgy, Benjamin Grenier-Boley, Alexandre Lecoeur, Gaà Lle Fontaine, Fabrice Danjou, Jorge Samper Gonzalez, et al. « Association of APOE-Independent Alzheimer Disease Polygenic Risk Score With Brain Amyloid Deposition in Asymptomatic Older Adults ». Neurology 99, no 5 (23 mai 2022): e462-475. https://doi.org/10.1212/WNL.0000000000200544.
  • Yates, Abi G., Elena Kislitsyna, Carla Alfonso Martin, Jiaying Zhang, Amy L. Sewell, Ane Goikolea-Vives, Valerie Cai, et al. « Montelukast Reduces Grey Matter Abnormalities and Functional Deficits in a Mouse Model of Inflammation-Induced Encephalopathy of Prematurity ». Journal of Neuroinflammation 19, no 1 (29 octobre 2022): 265. https://doi.org/10.1186/s12974-022-02625-5.
  • Ye, Shixin, et Jean Lehmann. « Genetic Code Degeneracy Is Established by the Decoding Center of the Ribosome ». Nucleic Acids Research 50, no 7 (22 avril 2022): 4113‑26. https://doi.org/10.1093/nar/gkac171.
  • You, Zhenzhen, Ming Jiang, Zhenghao Shi, Minghua Zhao, Cheng Shi, Shuangli Du, Anne-Sophie Hérard, Nicolas Souedet, et Thierry Delzescaux. « Multiscale Segmentation- and Error-Guided Iterative Convolutional Neural Network for Cerebral Neuron Segmentation in Microscopic Images ». Microscopy Research and Technique 85, no 11 (novembre 2022): 3541‑52. https://doi.org/10.1002/jemt.24206.
  • Youssov, Katia, Etienne Audureau, Henri Vandendriessche, Graca Morgado, Richard Layese, Cyril Goizet, Christophe Verny, Marie-Laure Bourhis, et Anne-Catherine Bachoud-Lévi. « The Burden of Huntington’s Disease: A Prospective Longitudinal Study of Patient/Caregiver Pairs ». Parkinsonism & Related Disorders 103 (octobre 2022): 77‑84. https://doi.org/10.1016/j.parkreldis.2022.08.023.
  • Zélicourt, Antoine de, Abdallah Fayssoil, Mbarka Dakouane-Giudicelli, Isley De Jesus, Ahmed Karoui, Faouzi Zarrouki, Florence Lefebvre, et al. « CD38-NADase Is a New Major Contributor to Duchenne Muscular Dystrophic Phenotype ». EMBO Molecular Medicine 14, no 5 (9 mai 2022): e12860. https://doi.org/10.15252/emmm.202012860.

NeurATRIS soutient l'organisation du congrès EuroGlia 2023, qui aura lieu du 08 au 11 juillet à Berlin.

 

"L'European Meeting on Glia Cells in Health and Diseases" a pour but de (i) favoriser les échanges et les interactions scientifiques au sein de la communauté des cellules gliales, mais également de (ii) former les jeunes chercheurs à travers des cours et des workshops thématiques de grande qualité.

Au programme cette année : 7 conférences plénières, 30 symposiums et plusieurs ateliers en lien avec les cellules gliales. Un cours d'introduction est également donné la veille, dans le but d'offrir la possibilité d'acquérir des connaissances de base sur la biologie des différents types de cellules gliales.
 

Plus d'infos

NeurATRIS co-organise avec le Club Français des Cellules Gliales et les jeunes chercheurs de l'institut NeuroMyoGène, la Journée des Cellules Gliales, le 23 mai 2023 à Lyon, en amont du congrès NeuroFrance.

Cette journée est organisée par les jeunes chercheurs et pour eux ! Doctorants, post-doctorants, ingénieurs et techniciens de la communauté des cellules gliales, venez présenter vos travaux sous la forme d'une présentation orale ou d'un poster. 

Au programme une conférence plénière donnée par le Pr. Mikael Simons (Munich, Allemagne), suivie de 4 symposiums, deux sessions poster et un évènement social à la fin de la journée. 

Inscriptions : du 1er février au 22 mai 2023.

Date limite de soumission des résumés :  1er mars 2023. 

Plus de détails. 

 

 

NeurATRIS soutient le 6ème congrès scientifique de la Société Française de Résonance Magnétique en Biologie et Médecine (SFRMBM), organisé du 27 au 29 mars 2023 au Centre International de Conférences de Sorbonne Université, à Paris ainsi que la participation de ses étudiants/ jeunes chercheurs, via la prise en charge de leur frais d'inscription.

Ce congrès sera l'occasion de faire le point sur les avancées méthodologiques et sur les applications innovantes en imagerie par résonance magnétique (IRM) et en spectroscopie par résonance magnétique (SRM). Les travaux qui seront présentés concernent les développements en physique et en technologie jusqu'aux applications cliniques en passant les applications précliniques sur petit animal et les nouvelles approches en traitement du signal. Ce congrès multidisciplinaire a pour objectif de regrouper des physiciens, chimistes, biologistes, informaticiens et médecins cliniciens dans le domaine des technologies pour la santé.
 

Dans le cadre du soutien à la formation des étudiants, NeurATRIS soutient l'organisation de la seconde édition de NeuroLabs, qui aura lieu le 12 janvier 2023, à l'Auditiorium du Campus Pierre et Marie Curie. Deux scientifiques de renom participeront à cette édition: Etienne Hirsch (ICM) et Laure Rondi-Reig (IBPS)

L'objectif principal de ce mini-colloque est de faire connaître les laboratoires de neurosciences affiliés à Sorbonne Université aux étudiants du Master BIP, afin de leur donner un aperçu des différentes équipes dans lesquelles ils pourraient effectuer leur doctorat. Cet évènement permet également aux étudiants de réfléchir à leur avenir et de gagner en confiance en discutant avec les différents membres des laboratoires. 

Dans le cadre du soutien de NeurATRIS à la formation des étudiants, le Professeur Alison Lloyd du Laboratoire de Biologie Moléculaire et Cellulaire de l'University College de Londres donnera un cours le 06 janvier 2023 aux étudiants du Master 2 BIP. Ce cours portera sur la régénération des nerfs périphériques et sera suivi d'une discussion et d'un déjeuner avec les étudiants. Tous les membres de NeurATRIS sont les bienvenus.

Nous sommes très heureux d'avoir réuni à nouveau la communauté NeurATRIS les 5 et 6 décembre 2022 pour l'Assemblée générale de notre infrastructure et la Journée des neurosciences translationnelles coorganisée avec Celphedia.

Merci à EATRIS pour leur présence et leur participation active à ces deux journées.

Merci à tous les intervenants et participants.

            

      

                   

       

Félicitations à Pauline Léal, étudiante en 3ème année de thèse au CEA MIRCen (sous la direction d'Alexis Bemelmans), qui a remporté le prix NeurATRIS de la meilleure communication orale, lors du challenge "Next Generation" organisé à l'occasion de la Journée des Neurosciences Translationnelle de NeurATRIS, le 06 décembre 2022.

Sa présentation était intitulée: "Development of an AAV-based model of tauopathy targeting the dentate gyrus to study the role of microglia in the spreading of toxic tau species" 
 

      

 

La Gordon conférence "Neuroimmune Communication in Health and Disease", aura lieu du 22 au 27 janvier 2023, au Ventura Beach Marriott Ventura, en Californie.

Durant ces 5 jours de conférence, différents sujets seront abordés avec notamment la neuroimmunologie du développement, les cellules gliales, l'axe intestin-cerveau, les barrières du cerveau, la neurodégénérescence, l'inflammation des tissus et les maladies infectieuses.

Plus de détails.

En 2021, les travaux de NeurATRIS ont générés 266 publications dans des journaux scientifiques à comité de lecture. Un grand bravo à toutes nos équipes de recherche et leurs collaborateurs !

 

  • Abjean, L., L. Ben Haim, M. Riquelme-Perez, P. Gipchtein, C. Derbois, M. A. Palomares, F. Petit, et al. « The JAK2-STAT3 Pathway Controls a Beneficial Proteostasis Response of Reactive Astrocytes in Huntington’s Disease ». BioRxiv, 29 avril 2021, 2021.04.29.441924. https://doi.org/10.1101/2021.04.29.441924.
  • Adams, David, Vincent Algalarrondo, Michael Polydefkis, Nitasha Sarswat, Michel S. Slama, et Jose Nativi-Nicolau. « Expert Opinion on Monitoring Symptomatic Hereditary Transthyretin-Mediated Amyloidosis and Assessment of Disease Progression ». Orphanet Journal of Rare Diseases 16, no 1 (3 octobre 2021): 411. https://doi.org/10.1186/s13023-021-01960-9.
  • Adams, David, Yukio Ando, Joao Melo Beirao, Teresa Coelho, Morie A. Gertz, Julian D. Gillmore, Philip N. Hawkins, Isabelle Lousada, Ole B. Suhr, et Giampaolo Merlini. « Expert Consensus Recommendations to Improve Diagnosis of ATTR Amyloidosis with Polyneuropathy ». Journal of Neurology 268, no 6 (juin 2021): 2109‑22. https://doi.org/10.1007/s00415-019-09688-0.
  • Adams, David, Michael Polydefkis, Alejandra González-Duarte, Jonas Wixner, Arnt V. Kristen, Hartmut H. Schmidt, John L. Berk, et al. « Long-Term Safety and Efficacy of Patisiran for Hereditary Transthyretin-Mediated Amyloidosis with Polyneuropathy: 12-Month Results of an Open-Label Extension Study ». The Lancet. Neurology 20, no 1 (janvier 2021): 49‑59. https://doi.org/10.1016/S1474-4422(20)30368-9.
  • Adanyeguh, Isaac M., Francesca Branzoli, Cécile Delorme, Aurélie Méneret, Marie-Lorraine Monin, Marie-Pierre Luton, Alexandra Durr, Emanoel Sabidussi, et Fanny Mochel. « Multiparametric Characterization of White Matter Alterations in Early Stage Huntington Disease ». Scientific Reports 11, no 1 (23 juin 2021): 13101. https://doi.org/10.1038/s41598-021-92532-1.
  • Aït Amiri, Sabrina, Cyrille Deboux, Feryel Soualmia, Nancy Chaaya, Maxime Louet, Eric Duplus, Sandrine Betuing, Brahim Nait Oumesmar, Nicolas Masurier, et Chahrazade El Amri. « Identification of First-in-Class Inhibitors of Kallikrein-Related Peptidase 6 That Promote Oligodendrocyte Differentiation ». Journal of Medicinal Chemistry 64, no 9 (13 mai 2021): 5667‑88. https://doi.org/10.1021/acs.jmedchem.0c02175.
  • Amador, Maria Del Mar, Marcela Gargiulo, Christilla Boucher, Ariane Herson, Stéphanie Staraci, François Salachas, Fabienne Clot, Cécile Cazeneuve, Isabelle Le Ber, et Alexandra Durr. « Who and Why? Requests for Presymptomatic Genetic Testing for Amyotrophic Lateral Sclerosis/Frontotemporal Dementia vs Huntington Disease ». Neurology. Genetics 7, no 1 (février 2021): e538. https://doi.org/10.1212/NXG.0000000000000538.
  • Andrianarivelo, Andry, Estefani Saint-Jour, Paula Pousinha, Sebastian P. Fernandez, Anna Petitbon, Veronique De Smedt-Peyrusse, Nicolas Heck, et al. « Disrupting D1-NMDA or D2-NMDA Receptor Heteromerization Prevents Cocaine’s Rewarding Effects but Preserves Natural Reward Processing ». Science Advances 7, no 43 (octobre 2021): eabg5970. https://doi.org/10.1126/sciadv.abg5970.
  • Antoun, Stephanie, Pierre Ellul, Hugo Peyre, Michelle Rosenzwajg, Pierre Gressens, David Klatzmann, et Richard Delorme. « Fever during Pregnancy as a Risk Factor for Neurodevelopmental Disorders: Results from a Systematic Review and Meta-Analysis ». Molecular Autism 12, no 1 (18 septembre 2021): 60. https://doi.org/10.1186/s13229-021-00464-4.
  • Arumugham, Shyam Sundar, Dwarakanath Srinivas, Janardhanan C. Narayanaswamy, T. S. Jaisoorya, Himani Kashyap, Philippe Domenech, Stéphane Palfi, Luc Mallet, Ganesan Venkatasubramanian, et Yc Janardhan Reddy. « Identification of Biomarkers That Predict Response to Subthalamic Nucleus Deep Brain Stimulation in Resistant Obsessive-Compulsive Disorder: Protocol for an Open-Label Follow-up Study ». BMJ Open 11, no 6 (22 juin 2021): e047492. https://doi.org/10.1136/bmjopen-2020-047492.
  • Audouard, Emilie, Valentin Oger, Béatrix Meha, Nathalie Cartier, Caroline Sevin, et Françoise Piguet. « Complete Correction of Brain and Spinal Cord Pathology in Metachromatic Leukodystrophy Mice ». Frontiers in Molecular Neuroscience 14 (21 mai 2021): 677895. https://doi.org/10.3389/fnmol.2021.677895.
  • Audouard, Emilie, Lisa Rousselot, Marc Folcher, Nathalie Cartier, et Françoise Piguet. « Optimized Protocol for Subcutaneous Implantation of Encapsulated Cells Device and Evaluation of Biocompatibility ». Frontiers in Bioengineering and Biotechnology 9 (24 juin 2021): 620967. https://doi.org/10.3389/fbioe.2021.620967.
  • Auvity, Sylvain, Sébastien Goutal, Fabien Caillé, Dominique Vodovar, Alain Pruvost, Catriona Wimberley, Claire Leroy, Matteo Tonietto, Michel Bottlaender, et Nicolas Tournier. « Pharmacokinetic Neuroimaging to Study the Dose-Related Brain Kinetics and Target Engagement of Buprenorphine in Vivo ». Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 18 février 2021. https://doi.org/10.1038/s41386-021-00976-w.
  • Bachasson, Damien, Alper Carras Ayaz, Jessie Mosso, Aurélie Canal, Jean-Marc Boisserie, Ericky C. A. Araujo, Olivier Benveniste, et al. « Lean Regional Muscle Volume Estimates Using Explanatory Bioelectrical Models in Healthy Subjects and Patients with Muscle Wasting ». Journal of Cachexia, Sarcopenia and Muscle 12, no 1 (février 2021): 39‑51. https://doi.org/10.1002/jcsm.12656.
  • Bachoud-Levi, Anne-Catherine, Renaud Massart, et Anne Rosser. « Cell Therapy in Huntington’s Disease: Taking Stock of Past Studies to Move the Field Forward ». Stem Cells 39, no 2 (février 2021): 144‑55. https://doi.org/10.1002/stem.3300.
  • Badin, Romina Aron, Anne-Catherine Bachoud-Levi, Gerhard Bauer, Monica Busse-Morris, Josep M. Canals, Philipp Capetian, Elena Cattaneo, et al. « Stem Cells for Huntington’s Disease (SC4HD): An International Consortium to Facilitate Stem Cell-Based Therapy for Huntington’s Disease ». Journal of Huntingtons Disease 10, no 2 (2021): 221‑26. https://doi.org/10.3233/JHD-210473.
  • Baligand, Celine, Olivier Barret, Amélie Tourais, Jean-Baptiste Pérot, Didier Thenadey, Fanny Petit, Géraldine Liot, et al. « Zero Echo Time 17O-MRI Reveals Decreased Cerebral Metabolic Rate of Oxygen Consumption in a Murine Model of Amyloidosis ». Metabolites 11, no 5 (22 avril 2021). https://doi.org/10.3390/metabo11050263.
  • Baligand, Celine, Lydiane Hirschler, Thom T. J. Veeger, Lena Vaclavu, Suzanne L. Franklin, Matthias J. P. van Osch, et Hermien E. Kan. « A Split-Label Design for Simultaneous Measurements of Perfusion in Distant Slices by Pulsed Arterial Spin Labeling ». Magnetic Resonance in Medicine 86, no 5 (novembre 2021): 2441‑53. https://doi.org/10.1002/mrm.28879.
  • Barret, Olivier, Lei Zhang, David Alagille, Cristian C. Constantinescu, Christine Sandiego, Caroline Papin, Jenna M. Sullivan, et al. « Dopamine D1 Receptor Agonist PET Tracer Development: Assessment in Non-Human Primates ». Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine, 12 février 2021. https://doi.org/10.2967/jnumed.120.256008.
  • Barth, Melanie, Mehtap Bacioglu, Niklas Schwarz, Renata Novotny, Janine Brandes, Marc Welzer, Sonia Mazzitelli, et al. « Microglial Inclusions and Neurofilament Light Chain Release Follow Neuronal α-Synuclein Lesions in Long-Term Brain Slice Cultures ». Molecular Neurodegeneration 16, no 1 (11 août 2021): 54. https://doi.org/10.1186/s13024-021-00471-2.
  • Bassignana, Giulia, Jennifer Fransson, Vincent Henry, Olivier Colliot, Violetta Zujovic, et Fabrizio De Vico Fallani. « Stepwise target controllability identifies dysregulations of macrophage networks in multiple sclerosis ». Network Neuroscience 5, no 2 (3 mai 2021): 337‑57. https://doi.org/10.1162/netn_a_00180.
  • Baudouin, Lucas, Noemie Ades, Kadia Kante, Antonny Czarnecki, Corinne Bachelin, Asha Baskaran, Dominique Langui, et al. « Co-Culture of Exogenous Oligodendrocytes with Unmyelinated Cerebella: Revisiting Ex Vivo Models and New Tools to Study Myelination ». Glia 69, no 8 (août 2021): 1916‑31. https://doi.org/10.1002/glia.24001.
  • Ben Haim, Lucile, Lucas Schirmer, Amel Zulji, Khalida Sabeur, Brice Tiret, Matthieu Ribon, Sandra Chang, et al. « Evidence for Glutamine Synthetase Function in Mouse Spinal Cord Oligodendrocytes ». Glia, 15 août 2021. https://doi.org/10.1002/glia.24071.
  • Ben Rehouma, Mouna, Toni Kfoury, Leila Hamdi, Meriem Bouchouareb, Mickael Soued, Dan Benhamou, et Jean Xavier Mazoit. « Acute Visceral Pain in Rats: Vagal Nerve Block Compared to Bupivacaine Administered Intramuscularly ». Anesthesia and Analgesia 133, no 5 (1 novembre 2021): 1311‑20. https://doi.org/10.1213/ANE.0000000000005697.
  • Benussi, Alberto, Enrico Premi, Stefano Gazzina, Chiara Brattini, Elisa Bonomi, Antonella Alberici, Lize Jiskoot, et al. « Progression of Behavioral Disturbances and Neuropsychiatric Symptoms in Patients With Genetic Frontotemporal Dementia ». Jama Network Open 4, no 1 (6 janvier 2021): e2030194. https://doi.org/10.1001/jamanetworkopen.2020.30194.
  • Benveniste, Olivier, Jean-Yves Hogrel, Lisa Belin, Melanie Annoussamy, Damien Bachasson, Aude Rigolet, Pascal Laforet, et al. « Sirolimus for Treatment of Patients with Inclusion Body Myositis: A Randomised, Double-Blind, Placebo-Controlled, Proof-of-Concept, Phase 2b Trial ». Lancet Rheumatology 3, no 1 (janvier 2021): E40‑48. https://doi.org/10.1016/S2665-9913(20)30280-0.
  • Bergström, Sofia, Julia Remnestål, Jamil Yousef, Jennie Olofsson, Ioanna Markaki, Stephanie Carvalho, Jean-Christophe Corvol, et al. « Multi-Cohort Profiling Reveals Elevated CSF Levels of Brain-Enriched Proteins in Alzheimer’s Disease ». Annals of Clinical and Translational Neurology 8, no 7 (2021): 1456‑70. https://doi.org/10.1002/acn3.51402.
  • Besse-Pinot, Elsa, Bruno Pereira, Franck Durif, Maria Livia Fantini, Elodie Durand, Berengere Debilly, Philippe Derost, et al. « Preoperative REM Sleep Behavior Disorder and Subthalamic Nucleus Deep Brain Stimulation Outcome in Parkinson Disease 1 Year After Surgery ». Neurology 97, no 20 (16 novembre 2021): E1994‑2006. https://doi.org/10.1212/WNL.0000000000012862.
  • Bigaut, Kévin, Mikaël Cohen, Françoise Durand-Dubief, Elisabeth Maillart, Evelyne Planque, Hélène Zephir, Christine Lebrun-Frenay, et Jérôme de Seze. « How to Switch Disease-Modifying Treatments in Multiple Sclerosis: Guidelines from the French Multiple Sclerosis Society (SFSEP) ». Multiple Sclerosis and Related Disorders 53 (1 août 2021): 103076. https://doi.org/10.1016/j.msard.2021.103076.
  • Biondetti, Emma, Mathieu D. Santin, Romain Valabregue, Graziella Mangone, Rahul Gaurav, Nadya Pyatigorskaya, Matthew Hutchison, et al. « The Spatiotemporal Changes in Dopamine Neuromelanin and Iron Characterizing Parkinson’s Disease ». Brain 144 (octobre 2021): 3114‑25. https://doi.org/10.1093/brain/awab191.
  • Blauwendraat, Cornelis, Hirotaka Iwaki, Mary B. Makarious, Sara Bandres-Ciga, Hampton L. Leonard, Francis P. Grenn, Julie Lake, et al. « Investigation of Autosomal Genetic Sex Differences in Parkinson’s Disease ». Annals of Neurology 90, no 1 (juillet 2021): 35‑42. https://doi.org/10.1002/ana.26090.
  • Boccazzi, Marta, Juliette Van Steenwinckel, Anne-Laure Schang, Valérie Faivre, Tifenn Le Charpentier, Cindy Bokobza, Zsolt Csaba, et al. « The Immune-Inflammatory Response of Oligodendrocytes in a Murine Model of Preterm White Matter Injury: The Role of TLR3 Activation ». Cell Death & Disease 12, no 2 (8 février 2021): 166. https://doi.org/10.1038/s41419-021-03446-9.
  • Bocchetta, Martina, Emily G. Todd, Georgia Peakman, David M. Cash, Rhian S. Convery, Lucy L. Russell, David L. Thomas, et al. « Differential Early Subcortical Involvement in Genetic FTD within the GENFI Cohort ». Neuroimage-Clinical 30 (2021): 102646. https://doi.org/10.1016/j.nicl.2021.102646.
  • Bodini, Benedetta, Matteo Tonietto, Laura Airas, et Bruno Stankoff. « Positron Emission Tomography in Multiple Sclerosis — Straight to the Target ». Nature Reviews Neurology 17, no 11 (novembre 2021): 663‑75. https://doi.org/10.1038/s41582-021-00537-1.
  • Bonvento, Gilles, et Juan P. Bolaños. « Astrocyte-Neuron Metabolic Cooperation Shapes Brain Activity ». Cell Metabolism 33, no 8 (3 août 2021): 1546‑64. https://doi.org/10.1016/j.cmet.2021.07.006.
  • Bortolanza, Mariza, Glauce C. do Nascimento, Rita Raisman-Vozari, et Elaine Del-Bel. « Doxycycline and Its Derivative, COL-3, Decrease Dyskinesia Induced by l-DOPA in Hemiparkinsonian Rats ». British Journal of Pharmacology 178, no 13 (juillet 2021): 2595‑2616. https://doi.org/10.1111/bph.15439.
  • Boshkovski, Tommy, Julien Cohen-Adad, Bratislav Misic, Isabelle Arnulf, Jean-Christophe Corvol, Marie Vidailhet, Stéphane Lehéricy, Nikola Stikov, et Matteo Mancini. « The Myelin-Weighted Connectome in Parkinson’s Disease ». Movement Disorders: Official Journal of the Movement Disorder Society, 22 décembre 2021. https://doi.org/10.1002/mds.28891.
  • Boshkovski, Tommy, Ljupco Kocarev, Julien Cohen-Adad, Bratislav Misic, Stephane Lehericy, Nikola Stikov, et Matteo Mancini. « The R1-Weighted Connectome: Complementing Brain Networks with a Myelin-Sensitive Measure ». Network Neuroscience 5, no 2 (2021): 358‑72. https://doi.org/10.1162/netn_a_00179.
  • Bougneres, Pierre. « Letter to the Editor: “A Genome-Wide Pharmacogenetic Study of Growth Hormone Responsiveness” ». Journal of Clinical Endocrinology & Metabolism 106, no 1 (janvier 2021): E397‑98. https://doi.org/10.1210/clinem/dgaa734.
  • Bougnères, Pierre, Salima Hacein-Bey-Abina, Ivan Labik, Catherine Adamsbaum, Clémence Castaignède, Céline Bellesme, et Manfred Schmidt. « Long-Term Follow-Up of Hematopoietic Stem-Cell Gene Therapy for Cerebral Adrenoleukodystrophy ». Human Gene Therapy, 4 mai 2021. https://doi.org/10.1089/hum.2021.053.
  • Bougneres, Pierre, Raphael Porcher, Laure Esterle, David Baker, Adrien de la Vaissiere, Sofia Meurisse, Sophie Valtat, Anne-Laure Castell, Pierre Mouriquand, et Alain-Jacques Valleron. « Exploring the Risk of Hypospadias in Children Born from Mothers Living Close to a Vineyard ». Plos One 16, no 4 (15 avril 2021): e0249800. https://doi.org/10.1371/journal.pone.0249800.
  • Boussac, Mathilde, Christophe Arbus, Julia Dupouy, Estelle Harroch, Vanessa Rousseau, Aurelie Croiset, Fabienne Ory-Magne, et al. « Personality Dimensions of Patients Can Change during the Course of Parkinson’s Disease ». Plos One 16, no 1 (7 janvier 2021): e0245142. https://doi.org/10.1371/journal.pone.0245142.
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  • Vergallo, Andrea, Pablo Lemercier, Enrica Cavedo, Simone Lista, Eugeen Vanmechelen, Ann De Vos, Henrik Zetterberg, et al. « Plasma β-Secretase1 Concentrations Correlate with Basal Forebrain Atrophy and Neurodegeneration in Cognitively Healthy Individuals at Risk for AD ». Alzheimer’s & Dementia 17, no 4 (2021): 629‑40. https://doi.org/10.1002/alz.12228.
  • Vergallo, Andrea, Simone Lista, Yuhai Zhao, Pablo Lemercier, Stefan J. Teipel, Marie-Claude Potier, Marie-Odile Habert, Bruno Dubois, Walter J. Lukiw, et Harald Hampel. « MiRNA-15b and MiRNA-125b Are Associated with Regional Aβ-PET and FDG-PET Uptake in Cognitively Normal Individuals with Subjective Memory Complaints ». Translational Psychiatry 11, no 1 (27 janvier 2021): 1‑11. https://doi.org/10.1038/s41398-020-01184-8.
  • Verger, A., J. Darcourt, M.-O. Habert, A. Pallardy, M. J. Santiago-Ribeiro, F. Le Jeune, P. Payoux, et al. « Neurotransmission imaging protocols guidelines for the exploration of movement disorders ». Medecine Nucleaire-Imagerie Fonctionnelle Et Metabolique 45, no 2 (avril 2021): 98‑111. https://doi.org/10.1016/j.mednuc.2021.02.001.
  • Verney, Catherine, Pierre Gressens, et Tania Vitalis. « Anatomie et physiologie du stress traumatique ». médecine/sciences 37, no 11 (1 novembre 2021): 1002‑10. https://doi.org/10.1051/medsci/2021165.
  • Vieites-Prado, Alba, et Nicolas Renier. « Tissue Clearing and 3D Imaging in Developmental Biology ». Development 148, no 18 (septembre 2021): dev199369. https://doi.org/10.1242/dev.199369.
  • Villain, Nicolas, G. Béra, M.-O. Habert, A. Kas, J. Aubert, O. Jaubert, R. Valabregue, et al. « Dopamine Denervation in the Functional Territories of the Striatum: A New MR and Atlas-Based 123I-FP-CIT SPECT Quantification Method ». Journal of Neural Transmission 128, no 12 (1 décembre 2021): 1841‑52. https://doi.org/10.1007/s00702-021-02434-9.
  • Vincent, Mélissa, Mylène Gaudin, Covadonga Lucas-Torres, Alan Wong, Carole Escartin, et Julien Valette. « Characterizing Extracellular Diffusion Properties Using Diffusion-Weighted MRS of Sucrose Injected in Mouse Brain ». NMR in Biomedicine 34, no 4 (avril 2021): e4478. https://doi.org/10.1002/nbm.4478.
  • Virlogeux, Amandine, Chiara Scaramuzzino, Sophie Lenoir, Rémi Carpentier, Morgane Louessard, Aurélie Genoux, Patricia Lino, et al. « Increasing Brain Palmitoylation Rescues Behavior and Neuropathology in Huntington Disease Mice ». Science Advances 7, no 14 (2 avril 2021): eabb0799. https://doi.org/10.1126/sciadv.abb0799.
  • Vukusic, Sandra, Iuliana Ionescu, Catherine Cornu, Nadine Bossard, Françoise Durand-Dubief, François Cotton, Luca Durelli, et al. « Oral Nomegestrol Acetate and Transdermal 17-Beta-Estradiol for Preventing Post-Partum Relapses in Multiple Sclerosis: The POPARTMUS Study ». Multiple Sclerosis (Houndmills, Basingstoke, England) 27, no 9 (août 2021): 1458‑63. https://doi.org/10.1177/1352458520978218.
  • Wagner, Sven, ChoongKu Lee, Lucia Rojas, Christian G. Specht, JeongSeop Rhee, Nils Brose, et Theofilos Papadopoulos. « The Α3 Subunit of GABAA Receptors Promotes Formation of Inhibitory Synapses in the Absence of Collybistin ». The Journal of Biological Chemistry 296 (juin 2021): 100709. https://doi.org/10.1016/j.jbc.2021.100709.
  • Wallon, David, Susana Boluda, Anne Rovelet-Lecrux, Manon Thierry, Julien Lagarde, Laetitia Miguel, Magalie Lecourtois, et al. « Clinical and Neuropathological Diversity of Tauopathy in MAPT Duplication Carriers ». Acta Neuropathologica 142, no 2 (1 août 2021): 259‑78. https://doi.org/10.1007/s00401-021-02320-4.
  • Wang, Liquan, Xiwen Sun, Linjie Lu, Arul Marie, Damien Carrel, Shu Zhao, Clemence Mille, Qiong Song, Yan Zhang, et Shixin Ye. « Optoproteomics Elucidates the Interactome of L-Type Amino Acid Transporter 3 (LAT3) ». Chemical Communications (Cambridge, England) 57, no 38 (11 mai 2021): 4734‑37. https://doi.org/10.1039/d0cc08423a.
  • Warhaftig, Gal, Noa Zifman, Chaya Mushka Sokolik, Renaud Massart, Orshay Gabay, Daniel Sapozhnikov, Farida Vaisheva, et al. « Reduction of DNMT3a and RORA in the Nucleus Accumbens Plays a Causal Role in Post-Traumatic Stress Disorder-like Behavior: Reversal by Combinatorial Epigenetic Therapy ». Molecular Psychiatry 26, no 12 (décembre 2021): 7481‑97. https://doi.org/10.1038/s41380-021-01178-y.
  • Welniarz, Quentin, Emmanuel Roze, Benoît Béranger, Aurélie Méneret, Marie Vidailhet, Stéphane Lehéricy, Pierre Pouget, Mark Hallett, Sabine Meunier, et Cécile Galléa. « Identification of a Brain Network Underlying the Execution of Freely Chosen Movements ». Cerebral Cortex (New York, N.Y.: 1991) 32, no 1 (23 novembre 2021): 216‑30. https://doi.org/10.1093/cercor/bhab204.
  • Wiatr, Kalina, Łukasz Marczak, Jean-Baptiste Pérot, Emmanuel Brouillet, Julien Flament, et Maciej Figiel. « Broad Influence of Mutant Ataxin-3 on the Proteome of the Adult Brain, Young Neurons, and Axons Reveals Central Molecular Processes and Biomarkers in SCA3/MJD Using Knock-In Mouse Model ». Frontiers in Molecular Neuroscience 14 (2021): 658339. https://doi.org/10.3389/fnmol.2021.658339.
  • Wimberley, Catriona, Sonia Lavisse, Ansel Hillmer, Rainer Hinz, Federico Turkheimer, et Paolo Zanotti-Fregonara. « Kinetic Modeling and Parameter Estimation of TSPO PET Imaging in the Human Brain ». European Journal of Nuclear Medicine and Molecular Imaging 49, no 1 (décembre 2021): 246‑56. https://doi.org/10.1007/s00259-021-05248-9.
  • Woodgate, Samuel, Philippa Morgan-Jones, Susanne Clinch, Cheney Drew, Rebecca Playle, Mohamed Bennasar, Yulia Hicks, et al. « Objectively Characterizing Huntington’s Disease Using a Novel Upper Limb Dexterity Test ». Journal of Neurology, 8 février 2021. https://doi.org/10.1007/s00415-020-10375-8.
  • Yang, Xiaojuan, Hervé Le Corronc, Pascal Legendre, Antoine Triller, et Christian G. Specht. « Differential Regulation of Glycinergic and GABAergic Nanocolumns at Mixed Inhibitory Synapses ». EMBO Reports 22, no 7 (5 juillet 2021): e52154. https://doi.org/10.15252/embr.202052154.
  • You, Zhenzhen, Ming Jiang, Zhenghao Shi, Xiaojuan Ning, Cheng Shi, Shuangli Du, Anne-Sophie Hérard, Caroline Jan, Nicolas Souedet, et Thierry Delzescaux. « Evaluation of Automated Segmentation Algorithms for Neurons in Macaque Cerebral Microscopic Images ». Microscopy Research and Technique, 27 avril 2021. https://doi.org/10.1002/jemt.23786.
  • Zhang, Tingting, Tengyuan Liu, Natalia Mora, Justine Guegan, Mathilde Bertrand, Ximena Contreras, Andi H. Hansen, et al. « Generation of Excitatory and Inhibitory Neurons from Common Progenitors via Notch Signaling in the Cerebellum ». Cell Reports 35, no 10 (8 juin 2021): 109208. https://doi.org/10.1016/j.celrep.2021.109208.

 

 

L’équipe « Neuropsychologie interventionnelle » (NPI, Inserm U955, ENS de Paris) dirigée par le Pr. Anne Catherine Bachoud-Lévi et dédiée à la compréhension des fonctions cognitives et à leurs atteintes au cours des maladies neurodégénératives, recherche 2 post-doctorants / ingénieurs de recherche pour un projet nécessitant des connaissances mixtes en science cognitive, apprentissage automatisé et traitement de la parole et du langage.

EATRIS, l'infrastructure européenne pour la médecine translationnelle, est à la recherche d'un(e) Senior Business Strategy Developer, pour développer une stratégie commerciale et mettre en place une entité opérationnelle dans le cadre de la plate-forme européenne pour les maladies neurodégénératives (EPND), un nouveau projet financé par l'Innovative Initiative Médicaments (IMI).

✔ 32-40 heures par semaine
✔ Date de début : dès que possible
✔ Détachement des institutions EATRIS possible


Les candidatures seront examinées lors de la soumission et les candidats pourront être contactés pour un entretien avant la date de clôture (15 septembre).

Plus de détails sur: EATRIS website jobs listing, Twitter, LinkedIn et Facebook.

 

Meeting annuel du Club des Cellules Gliales, organisé du 18 au 22 octobre 2021, en collaboration avec NeurATRIS

 

Cette rencontre, organisée de façon 100% virtuelle sur 5 après-midi, offre une couverture très complète du domaine florissant de la recherche sur la glie, à travers 2 conférences plénières, 5 colloques, 2 sessions flash talk pour les étudiants et post-doctorants, 2 sessions posters et l'assemblée générale. Elle réunira des scientifiques experts dans le domaine de la biologie des cellules gliales venant de France, du Royaume-Uni, d'Allemagne et d'Espagne.

 

Conçue pour être un forum vivant et stimulant pour les chercheurs et les étudiants du monde universitaire ou de l'industrie, cet évènement constituera une véritable opportunité pour approfondir ses connaissances sur les cellules gliales et sur les techniques de pointe permettant de les étudier. Les jeunes chercheurs auront l'opportunité de présenter leurs travaux sous la forme d'un talk sélectionné sur résumé, d'un flash talk pour présenter leur poster ou d'un poster virtuel.

 

Plus d'informations

Inscriptions

 

Lorentz Workshop: Best practices & tools for Diffusion MR Spectrometry

Dans le cadre de son soutien à la formation, NeurATRIS co-organise un workshop de 5 jours, entièrement dédié à la spectrométrie RMN de diffusion.

Ce workshop aura lieu du 20 au 24 septembre 2021, à Leiden aux Pays-Bas.

Son but est de :

(1) Lancer une plateforme ouverte et conviviale, utilisée pour traiter, analyser et modéliser les données expérimentales acquises

(2) Initier un référentiel de données (protocoles d'acquisition, contacts travaillant dans le domaine, ...) rattaché à la plate-forme ouverte, de façon à élargir l'accessibilité des données DW-MRS

(3) Rédiger un «consensus paper» reprenant les principes de la DW-MRS et fournissant des recommandations de protocoles ainsi qu’une description de la nouvelle plate-forme « open source »

Pour plus d'informations, n'hésitez pas à consulter le site du workshop : https://www.lorentzcenter.nl/best-practices-en-tools-for-diffusion-mr-spectroscopy.html

L'European Meeting on Glial Cells in Health and Disease est un meeting incontournable dans le domaine des neurosciences, avec à la fois une vocation éducative pour les jeunes chercheurs à travers des cours et des workshops thématiques, et une vocation d'échange et d'interaction scientifique de grande qualité sur les cellules gliales.

Le programme scientifique débute par une journée de cours destinée aux étudiants et jeunes chercheurs souhaitant se familiariser avec la thématique des cellules gliales. Il se poursuit par 7 présentations plénières, 30 symposia et des workshops thématiques, traitant de différents aspects sur les cellules gliales et leur implication dans les pathologies neurodégénératives.

Il aura lieu cette année intégralement en ligne du 5 au 9 juillet avec le soutien de NeurATRIS. Pour plus d'informations, n'hésitez pas à consulter le site du meeting.

Société des Neurosciences - Accueil | Facebook

Le prochain colloque NeuroFrance aura lieu entièrement en ligne, du 19 au 21 mai 2021, avec le soutien de NeurATRIS. Retrouvez-nous sur notre stand virtuel, ainsi que lors du symposium intitulé "Nouvel éclairage sur la physiopathologie des troubles du neurodéveloppement", spécifiquement soutenu par NeurATRIS et présidé par Pierre Gressens, membre de NeurATRIS.

Retrouvez toutes les informations ici : https://www.neurosciences.asso.fr/SN21/ 

146 publications dans des journaux à comité de lecture, pour NeurATRIS en 2020, soit 30% de plus qu'en 2019!

 

  • Adams, David, Yukio Ando, João Melo Beirão, Teresa Coelho, Morie A. Gertz, Julian D. Gillmore, Philip N. Hawkins, Isabelle Lousada, Ole B. Suhr, et Giampaolo Merlini. « Expert Consensus Recommendations to Improve Diagnosis of ATTR Amyloidosis with Polyneuropathy ». Journal of Neurology, 6 janvier 2020. https://doi.org/10.1007/s00415-019-09688-0.
  • Antinucci, Paride, Adna Dumitrescu, Charlotte Deleuze, Holly J. Morley, Kristie Leung, Tom Hagley, Fumi Kubo, Herwig Baier, Isaac H. Bianco, et Claire Wyart. « A Calibrated Optogenetic Toolbox of Stable Zebrafish Opsin Lines ». ELife 9 (27 mars 2020). https://doi.org/10.7554/eLife.54937.
  • Bachoud-Lévi, Anne-Catherine. « Long before Huntington’s Disease: What Matters Most? » The Lancet. Neurology 19, no 6 (juin 2020): 473‑75. https://doi.org/10.1016/S1474-4422(20)30156-3.
  • Bachoud-Lévi, Anne-Catherine et on behalf the Multicentric Intracerebral Grafting in Huntington’s Disease Group. « Human Fetal Cell Therapy in Huntington’s Disease: A Randomized, Multicenter, Phase II Trial ». Movement Disorders: Official Journal of the Movement Disorder Society 35, no 8 (août 2020): 1323‑35. https://doi.org/10.1002/mds.28201.
  • Balsiger, Fabian, Alain Jungo, Olivier Scheidegger, Pierre G. Carlier, Mauricio Reyes, et Benjamin Marty. « Spatially Regularized Parametric Map Reconstruction for Fast Magnetic Resonance Fingerprinting ». Medical Image Analysis 64 (août 2020): 101741. https://doi.org/10.1016/j.media.2020.101741.
  • Baumann, Matthias, Frederik Bartels, Carsten Finke, Catherine Adamsbaum, Yael Hacohen, Kevin Rostásy, et E.U. paediatric MOG consortium. « E.U. Paediatric MOG Consortium Consensus: Part 2 - Neuroimaging Features of Paediatric Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disorders ». European Journal of Paediatric Neurology: EJPN: Official Journal of the European Paediatric Neurology Society 29 (novembre 2020): 14‑21. https://doi.org/10.1016/j.ejpn.2020.10.002.
  • Ben M’Barek, Karim, Stéphane Bertin, Elena Brazhnikova, Céline Jaillard, Walter Habeler, Alexandra Plancheron, Claire-Maëlle Fovet, et al. « Clinical-Grade Production and Safe Delivery of Human ESC Derived RPE Sheets in Primates and Rodents ». Biomaterials 230 (1 février 2020): 119603. https://doi.org/10.1016/j.biomaterials.2019.119603.
  • Bendifallah, Maya, Virginie Redeker, Elodie Monsellier, Luc Bousset, Tracy Bellande, et Ronald Melki. « Interaction of the Chaperones Alpha B-Crystallin and CHIP with Fibrillar Alpha-Synuclein: Effects on Internalization by Cells and Identification of Interacting Interfaces ». Biochemical and Biophysical Research Communications 527, no 3 (30 juin 2020): 760‑69. https://doi.org/10.1016/j.bbrc.2020.04.091.
  • Bey, Karim, Johan Deniaud, Laurence Dubreil, Béatrice Joussemet, Joseph Cristini, Carine Ciron, Juliette Hordeaux, et al. « Intra-CSF AAV9 and AAVrh10 Administration in Nonhuman Primates: Promising Routes and Vectors for Which Neurological Diseases? » Molecular Therapy. Methods & Clinical Development 17 (12 juin 2020): 771‑84. https://doi.org/10.1016/j.omtm.2020.04.001.
  • Biondetti, Emma, Rahul Gaurav, Lydia Yahia-Cherif, Graziella Mangone, Nadya Pyatigorskaya, Romain Valabrègue, Claire Ewenczyk, et al. « Spatiotemporal Changes in Substantia Nigra Neuromelanin Content in Parkinson’s Disease ». Brain: A Journal of Neurology 143, no 9 (1 septembre 2020): 2757‑70. https://doi.org/10.1093/brain/awaa216.
  • Boueid, Marie-José, Aya Mikdache, Emilie Lesport, Cindy Degerny, et Marcel Tawk. « Rho GTPases Signaling in Zebrafish Development and Disease ». Cells 9, no 12 (8 décembre 2020). https://doi.org/10.3390/cells9122634.
  • Bousset, Luc, Nina Luckgei, Mehdi Kabani, Carole Gardiennet, Anne K. Schütz, Ronald Melki, Beat H. Meier, et Anja Böckmann. « Prion Amyloid Polymorphs - The Tag Might Change It All ». Frontiers in Molecular Biosciences 7 (2020): 190. https://doi.org/10.3389/fmolb.2020.00190.
  • Brasseur, Laurent, Audrey Coens, Jehan Waeytens, Ronald Melki, et Luc Bousset. « Dipeptide Repeat Derived from C9orf72 Hexanucleotide Expansions Forms Amyloids or Natively Unfolded Structures in Vitro ». Biochemical and Biophysical Research Communications 526, no 2 (28 mai 2020): 410‑16. https://doi.org/10.1016/j.bbrc.2020.03.108.
  • Bucciantini, Monica, Manuela Leri, Massimo Stefani, Ronald Melki, Sandra Zecchi-Orlandini, et Daniele Nosi. « The Amphipathic GM1 Molecule Stabilizes Amyloid Aggregates, Preventing Their Cytotoxicity ». Biophysical Journal 119, no 2 (21 juillet 2020): 326‑36. https://doi.org/10.1016/j.bpj.2020.06.005.
  • Burke, Elizabeth A., Kyle E. Reichard, Lynne A. Wolfe, Brian P. Brooks, John J. DiGiovanna, Donald W. Hadley, Tanya J. Lehky, et al. « A Novel Frameshift Mutation in SOX10 Causes Waardenburg Syndrome with Peripheral Demyelinating Neuropathy, Visual Impairment and the Absence of Hirschsprung Disease ». American Journal of Medical Genetics. Part A 182, no 5 (mai 2020): 1278‑83. https://doi.org/10.1002/ajmg.a.61542.
  • Cantaut-Belarif, Yasmine, Adeline Orts Del’Immagine, Margot Penru, Guillaume Pézeron, Claire Wyart, et Pierre-Luc Bardet. « Adrenergic Activation Modulates the Signal from the Reissner Fiber to Cerebrospinal Fluid-Contacting Neurons during Development ». ELife 9 (13 octobre 2020): e59469. https://doi.org/10.7554/eLife.59469.
  • Carneiro, Fábio, Dario Saracino, Vincent Huin, Fabienne Clot, Cécile Delorme, Aurélie Méneret, Stéphane Thobois, et al. « Isolated Parkinsonism Is an Atypical Presentation of GRN and C9orf72 Gene Mutations ». Parkinsonism & Related Disorders 80 (novembre 2020): 73‑81. https://doi.org/10.1016/j.parkreldis.2020.09.019.
  • Celestine, Marina, Nachiket A. Nadkarni, Clément M. Garin, Salma Bougacha, et Marc Dhenain. « Sammba-MRI: A Library for Processing SmAll-MaMmal BrAin MRI Data in Python ». Frontiers in Neuroinformatics 14 (2020): 24. https://doi.org/10.3389/fninf.2020.00024.
  • Chougar, Lydia, Johann Faouzi, Nadya Pyatigorskaya, Lydia Yahia-Cherif, Rahul Gaurav, Emma Biondetti, Marie Villotte, et al. « Automated Categorization of Parkinsonian Syndromes Using Magnetic Resonance Imaging in a Clinical Setting ». Movement Disorders: Official Journal of the Movement Disorder Society, 2 novembre 2020. https://doi.org/10.1002/mds.28348.
  • Cleret de Langavant, Laurent, Eléonore Bayen, Anne-Catherine Bachoud-Lévi, et Kristine Yaffe. « Approximating Dementia Prevalence in Population-Based Surveys of Aging Worldwide: An Unsupervised Machine Learning Approach ». Alzheimer’s & Dementia (New York, N. Y.) 6, no 1 (2020): e12074. https://doi.org/10.1002/trc2.12074.
  • Constans, Charlotte, Harry Ahnine, Mathieu Santin, Stephane Lehericy, Mickael Tanter, Pierre Pouget, et Jean-Francois Aubry. « Non-Invasive Ultrasonic Modulation of Visual Evoked Response by GABA Delivery through the Blood Brain Barrier ». Journal of Controlled Release 318 (février 2020): 223‑31. https://doi.org/10.1016/j.jconrel.2019.12.006.
  • Courte, Josquin, Luc Bousset, Ysander Von Boxberg, Catherine Villard, Ronald Melki, et Jean-Michel Peyrin. « The Expression Level of Alpha-Synuclein in Different Neuronal Populations Is the Primary Determinant of Its Prion-like Seeding ». Scientific Reports 10, no 1 (17 mars 2020): 4895. https://doi.org/10.1038/s41598-020-61757-x.
  • Cresto, Noémie, Marie-Claude Gaillard, Camille Gardier, Francesco Gubinelli, Elsa Diguet, Déborah Bellet, Laurine Legroux, et al. « The C-Terminal Domain of LRRK2 with the G2019S Mutation Is Sufficient to Produce Neurodegeneration of Dopaminergic Neurons in Vivo ». Neurobiology of Disease 134 (février 2020): 104614. https://doi.org/10.1016/j.nbd.2019.104614.
  • Daniel, Malo, Laurence Dubreil, Romain Fleurisson, Jean-Paul Judor, Timothée Bresson, Sophie Brouard, Arnaud Favier, Marie-Thérèse Charreyre, et Sophie Conchon. « Multiscale Fluorescent Tracking of Immune Cells in the Liver with a Highly Biocompatible Far-Red Emitting Polymer Probe ». Scientific Reports 10, no 1 (16 octobre 2020): 17546. https://doi.org/10.1038/s41598-020-74621-9.
  • De Mattos, Eduardo P., Anne Wentink, Carmen Nussbaum-Krammer, Christian Hansen, Steven Bergink, Ronald Melki, et Harm H. Kampinga. « Protein Quality Control Pathways at the Crossroad of Synucleinopathies ». Journal of Parkinson’s Disease 10, no 2 (2020): 369‑82. https://doi.org/10.3233/JPD-191790.
  • De Nicola, Alejandro F., Maria Meyer, Rachida Guennoun, Michael Schumacher, Hazel Hunt, Joseph Belanoff, E. Ronald de Kloet, et Maria Claudia Gonzalez Deniselle. « Insights into the Therapeutic Potential of Glucocorticoid Receptor Modulators for Neurodegenerative Diseases ». International Journal of Molecular Sciences 21, no 6 (20 mars 2020). https://doi.org/10.3390/ijms21062137.
  • Deruelle, Tristan, Frank Kober, Adriana Perles-Barbacaru, Thierry Delzescaux, Vincent Noblet, Emmanuel L. Barbier, et Michel Dojat. « A Multicenter Preclinical MRI Study: Definition of Rat Brain Relaxometry Reference Maps ». Frontiers in Neuroinformatics 14 (2020): 22. https://doi.org/10.3389/fninf.2020.00022.
  • Dhenain, Marc. « Estimation du nombre de cas de covid-19 en France et dans différents pays: homogénéisation basée sur la mortalité ». Bulletin de l’Académie Vétérinaire de France, no 2 (2020). https://doi.org/10.4267/2042/70840.
  • Djellaoui, Abdenour, Lilia Seddik, Laurent Cleret De Langavant, Samuel Cattan, Anne Catherine Bachoud-Lévi, et Hassan Hosseini. « Posterior Reversible Encephalopathy Syndrome Associated with SARS-CoV-2 Infection ». Journal of Neurology, Neurosurgery, and Psychiatry, 27 juillet 2020. https://doi.org/10.1136/jnnp-2020-323923.
  • Dos Santos Pereira, Maurício, Gabriel Henrique Dias Abreu, Jeremy Rocca, Sabah Hamadat, Rita Raisman-Vozari, Patrick Pierre Michel, et Elaine Del Bel. « Contributive Role of TNF-α to L-DOPA-Induced Dyskinesia in a Unilateral 6-OHDA Lesion Model of Parkinson’s Disease ». Frontiers in Pharmacology 11 (2020): 617085. https://doi.org/10.3389/fphar.2020.617085.
  • Dumas, Laura, Solène Clavreul, Jason Durand, Edwin Hernandez-Garzon, Lamiae Abdeladim, Raphaëlle Barry-Martinet, Alicia Caballero-Megido, et al. « In Utero Electroporation of Multiaddressable Genome-Integrating Color (MAGIC) Markers to Individualize Cortical Mouse Astrocytes ». Journal of Visualized Experiments: JoVE, no 159 (21 mai 2020). https://doi.org/10.3791/61110.
  • Echaniz-Laguna, Andoni, Jean-Marie Cuisset, Lucie Guyant-Marechal, Patrick Aubourg, Laurent Kremer, Naziha Baaloul, Alain Verloes, et al. « Giant Axonal Neuropathy: A Multicenter Retrospective Study with Genotypic Spectrum Expansion ». Neurogenetics 21, no 1 (janvier 2020): 29‑37. https://doi.org/10.1007/s10048-019-00596-z.
  • Echaniz-Laguna, Andoni, Xavière Lornage, Pascal Laforêt, Mette C. Orngreen, Evelina Edelweiss, Guy Brochier, Mai T. Bui, et al. « A New Glycogen Storage Disease Caused by a Dominant PYGM Mutation ». Annals of Neurology 88, no 2 (août 2020): 274‑82. https://doi.org/10.1002/ana.25771.
  • Fargeot, Guillaume, Corinne Dupel-Pottier, Maeva Stephant, Julien Lazarovici, Laure Thomas, Capucine Mouthon-Reignier, Benramdane Riad, et al. « Brentuximab Vedotin Treatment Associated with Acute and Chronic Inflammatory Demyelinating Polyradiculoneuropathies ». Journal of Neurology, Neurosurgery, and Psychiatry 91, no 7 (juillet 2020): 786‑88. https://doi.org/10.1136/jnnp-2020-323124.
  • Fleiss, Bobbi, Pierre Gressens, et Helen B. Stolp. « Cortical Gray Matter Injury in Encephalopathy of Prematurity: Link to Neurodevelopmental Disorders ». Frontiers in Neurology 11 (2020): 575. https://doi.org/10.3389/fneur.2020.00575.
  • Fréchou, Magalie, Xiaoyan Zhu, Philippe Liere, Antoine Pianos, Michael Schumacher, Claudia Mattern, et Rachida Guennoun. « Dose-Dependent and Long-Term Cerebroprotective Effects of Intranasal Delivery of Progesterone after Ischemic Stroke in Male Mice ». Neuropharmacology 170 (15 juin 2020): 108038. https://doi.org/10.1016/j.neuropharm.2020.108038.
  • Fritz, Rebecca G., Elke Zimmermann, Jean-Luc Picq, Corinne Lautier, Martin Meier, Sabine Kästner, et Daniel Schmidtke. « Sex-Specific Patterns of Age-Related Cerebral Atrophy in a Nonhuman Primate Microcebus Murinus ». Neurobiology of Aging 91 (juillet 2020): 148‑59. https://doi.org/10.1016/j.neurobiolaging.2020.02.027.
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ADVANCE is a 30-month EU training project, supported by Erasmus Plus fund with the objective to develop a 3-stage learning programme to support early-career biomedical scientists in developing currently missing scientific knowledge, transversal skills and competences to meet the key challenge areas existing in the ATMP development cycle. 

The ADVANCE online course launched on December 1st2020 and is completely open and free of charge to anyone interested in the ATMPs development topic. The course consists of ca. 7 hours of interactive lectures and nearly 20 hours of independent hands-on and reading assignments. It is all self-paced, and participants can move through the course as their schedule allows. 

This online course is divided into 4 Units representing the key challenges of the ATMPs development cycle: Scientific, Manufacturing, Reimbursement and Regulatory. You will hear 12 experts across academia, industry, regulatory sector and patient organisation discuss the key aspects in the ATMP development pipeline. The lectures are interspersed with questions to help participants stay engaged and think along. 

If you are interested in learning more about the ADVANCE Project and what else it has to offer, visit the website and follow it on LinkedIn and Twitter.   

ONLINE COURSE: Register Here! 

With the help of NeurATRIS and EATRIS, the French Club of Glial Cells offers a mini-symposium on innovating therapies for glial cells related diseases on November 25, 2020 at 14:00 CET.

The diseases of the nervous system including tumors are among the most dreadful diseases in humans. While the final outcome of these diseases is almost invariably due to neuronal dysfunction and death, glial cells often appear to be at the origin or to largely participate to the neuron unsettling. Thus, designing therapies directly targeting glial cells is highly relevant for the large majority of diseases of the central and peripheral nervous system (CNS/PNS).

As glial cells provide an undeniable and significant support to neuron function and survival, an exciting novel way to tackle nervous system diseases is to design therapies that will modify, improve or sustain this support in order to prevent neuronal cell dysfunction or death.

In this webinar, 3 reknowned speakers will illustrate this strategy using various technological approaches and treatments in diverse types of glial-cells related pathologies of the CNS and PNS.

 

With the help of NeurATRIS and EATRIS, the GDR Microglia and Neuroinflammation offers a mini-symposium on the role of glial cells in health and disease on December 3, 2020 at 14:00 CET.

As microglia were found to play major role in CNS development and interacts with neurons in the healthy brain, an exciting novel way to tackle nervous system diseases is to better understand how microglia during neuroinflammation contribute to neuronal cell dysfunction or death. In this symposium, we propose to apprehend the role of microglial cells in early stage of CNS diseases through various CNS pathological models. The goal is to offer a large enough diversity of speakers to be attractive for a large amount of neuroscientists interested in the fields of microglia, neuroinflammation and neurodegeneration.

Speakers:

  • Rosa Paolicelli (Université de Lausanne, Switzerland): “The many roles of microglia in neurodegeneration”
  • Juliette Van Steenwinckel (Université Paris Diderot, France) “Microglial perturbation in neurodevelopmental disorders induced by early exposure to inflammation”
  • Pierre Szepetowski / Sylvian Bauer (INMED, France) “Early cellular and molecular alterations in cytomegalovirus infection of the fetal brain: microglia and chemokines as therapeutic targets?”

REGISTER HERE

More information about the program…

Rosa C. Paolicelli
Department of Biomedical Sciences, University of Lausanne
The many roles of microglia in neurodegeneration

Abstract: Microglia are implicated in a variety of functions in the central nervous system, ranging from shaping neural circuits during early brain development, to surveying the brain parenchyma, and providing trophic support to neurons across the entire lifespan. In neurodegeneration, microglia have been considered for long time mere bystanders, accompanying and worsening neuronal damage. However, recent evidence indicates that microglia can causally contribute to neurodegenerative diseases, and that their dysfunction can even be at the origin of the pathology. In fact, the broad range of physiological roles microglia play in the healthy brain suggest that faulty microglia can initiate neurodegeneration through several possible mechanisms. In particular, in this webinar, we will discuss how dysfunctional synaptic pruning by microglia significantly affects synaptic function, thus putting microglia center stage in the pathogenesis of brain disorders.

Juliette Van Steenwinckel
NeuroDiderot laboratory (UMR1141 INSERM/University of Paris)
Microglial perturbation in neurodevelopmental disorders induced by early exposure to inflammation.

Abstract: Perinatal inflammation is the leading cause of neurodevelopmental injuries including periventricular white matter injury (PWMI), in the premature newborn. Brain inflammation alters development through neuroinflammatory processes including activation of homeostatic microglia toward a pro-inflammatory and neurotoxic phenotype causing white matter defect. Investigating immune regulators of microglial activation in model of WMI in mice pups could be an effective strategy to prevent PWMI. We presented here an in-depth analysis of microglial activation and phenotype in our model and an original neuroprotective approach employing 3DNA nanocarriers as a cargo to target these regulators specifically in microglia allowing to alleviate neuroinflammatory processes and improve myelination reducing the incidence and severity of perinatal brain injuries.

Pierre Szepetowski / Sylvian Bauer
Mediterranean Institute of Neurobiology (INMED), INSERM, Aix-Marseille University.
Cytomegalovirus Infection of the Rat Developing Brain in Utero: Fetal Microglia and a Viral Chemokine as Targets against Neuropathogenesis (Part I and II)

Abstract: Congenital cytomegalovirus (CMV) infections of the brain are one leading cause of human neurodevelopmental disorders. Despite their frequency and severity, neuropathogenesis remains elusive and no satisfactory therapy is available. In the past years, studies in rodent models have helped in identifying various possible pathogenic processes that included immune alterations. More pathophysiological insights, particularly into the early events following CMV infection of the developing brain, are needed. To reach this aim, we have designed and studied a model of CMV infection of the rat developing brain in utero. In this model, the postnatal manifestations seen in CMV-infected pups recapitulated several aspects of the human disease. Brain immune alterations were detected at the cellular and molecular levels. Recent past as well as ongoing experiments indicate that fetal microglia on the one hand, and a chemokine encoded by the CMV genome on the other hand, might play pivotal roles in neuropathogenesis. These findings might provide proof-of-principle towards the future design of approvable therapeutic options.

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