Associations are mobilized during the CoVid19 epidemic to help persons with neurodegenerative diseases to face the situation by giving advice for patients and their families.

You can read here the newsletter from Fondation Vaincre Alzheimer, with advice about confinement, hygene measures...

The Michael J Fox Foundation offers a webinar with information about the coronavirus for Parkinson's community.

Stay safe and strong !

In 2019, NeurATRIS research activities generated 110 publications in peer-reviewed journals. NeurATRIS has now published 550 publications since 2014!

• Acuña, Leonardo, Sabah Hamadat, Natalia S. Corbalán, Florencia González-Lizárraga, Mauricio dos-Santos-Pereira, Jérémy Rocca, Julia Sepúlveda Díaz, et al. « Rifampicin and Its Derivative Rifampicin Quinone Reduce Microglial Inflammatory Responses and Neurodegeneration Induced In Vitro by α-Synuclein Fibrillary Aggregates ». Cells 8, n^o 8 (25 juillet 2019). https://doi.org/10.3390/cells8080776.
• Alam, Parvez, Luc Bousset, Ronald Melki, et Daniel E. Otzen. « Alpha-Synuclein Oligomers and Fibrils: A Spectrum of Species, a Spectrum of Toxicities ». Journal of Neurochemistry 150, n^o 5 (septembre 2019): 522‑34. https://doi.org/10.1111/jnc.14808.
• Alliot, Julien, Ioanna Theodorou, Frédéric Ducongé, Edmond Gravel, et Eric Doris. « Polyamine Transport System-Targeted Nanometric Micelles Assembled from Epipodophyllotoxin-Amphiphiles ». Chemical Communications 55, n^o 99 (10 décembre 2019): 14968‑71. https://doi.org/10.1039/C9CC07883E.
• Alliot, Julien, Ioanna Theodorou, Dinh-Vu Nguyen, Cynthia Forier, Frédéric Ducongé, Edmond Gravel, et Eric Doris. « Tumor Targeted Micellar Nanocarriers Assembled from Epipodophyllotoxin-Based Amphiphiles ». Nanoscale 11, n^o 19 (16 mai 2019): 9756‑59. https://doi.org/10.1039/C9NR01068H.
• Androuin, Alexandre, Yah-Se Abada, Myriam Ly, Mathieu Santin, Alexandra Petiet, Stéphane Epelbaum, Anne Bertrand, et Benoît Delatour. « Activity-Induced MEMRI Cannot Detect Functional Brain Anomalies in the APPxPS1-Ki Mouse Model of Alzheimer’s Disease ». Scientific Reports 9, n^o 1 (4 février 2019): 1140. https://doi.org/10.1038/s41598-018-37980-y.
• Arai, Yoko, Andrzej W. Cwetsch, Eva Coppola, Sara Cipriani, Hidenori Nishihara, Hiroaki Kanki, Yoann Saillour, et al. « Evolutionary Gain of Dbx1 Expression Drives Subplate Identity in the Cerebral Cortex ». Cell Reports 29, n^o 3 (15 octobre 2019): 645-658.e5. https://doi.org/10.1016/j.celrep.2019.09.007.
• Bachoud-Levi, Anne-Catherine, Joaquim Ferreira, Renaud Massart, Katia Youssov, Anne Rosser, Monica Busse, David Craufurd, et al. « International Guidelines for the Treatment of Huntington’s Disease ». Frontiers in Neurology 10 (3 juillet 2019): 710. https://doi.org/10.3389/fneur.2019.00710.
• Badin, Romina Aron, Katie Binley, Nadja Van Camp, Caroline Jan, Jeanne Gourlay, Camille Robert, Pauline Gipchtein, et al. « Gene Therapy for Parkinson’s Disease: Preclinical Evaluation of Optimally Configured TH:CH1 Fusion for Maximal Dopamine Synthesis ». Molecular Therapy-Methods & Clinical Development 14 (13 septembre 2019): 206‑16. https://doi.org/10.1016/j.omtm.2019.07.002.
• Badin, Romina Aron, Aurore Bugi, Susannah Williams, Marta Vadori, Marie Michael, Caroline Jan, Alberto Nassi, et al. « MHC Matching Fails to Prevent Long-Term Rejection of IPSC-Derived Neurons in Non-Human Primates ». Nature Communications 10, n^o 1 (25 septembre 2019): 1‑12. https://doi.org/10.1038/s41467-019-12324-0.
• Baghdoyan, Sandrine, Guillaume Bassez, Etienne Audureau, et Marc Peschanski. « Recherche pharmacologique et cellules souches pluripotentes : du paradigme expérimental novateur à l’essai clinique fructueux | médecine/sciences ». Med Sci 35, n^o 1 (janvier 2019): 26‑29. https://doi.org/10.1051/medsci/2018316.
• Barrault, Laetitia, Jacqueline Gide, Tingting Qing, Lea Lesueur, Jorg Tost, Jerome Alexandre Denis, Michel Cailleret, et al. « Cells | Free Full-Text | Expression of miRNAs from the Imprinted DLK1/DIO3 Locus Signals the Osteogenic Potential of Human Pluripotent Stem Cells | HTML ». Cells 8, n^o 12 (novembre 2019). https://doi.org/10.3390/cells8121523.
• Ben M’Barek, Karim, et Christelle Monville. « Cell Therapy for Retinal Dystrophies: From Cell Suspension Formulation to Complex Retinal Tissue Bioengineering ». Stem Cells International, 2019. https://doi.org/10.1155/2019/4568979.
• Beurton, Fleur, Przemyslaw Stempor, Matthieu Caron, Alex Appert, Yang Dong, Ron A-J Chen, David Cluet, et al. « Physical and functional interaction between SET1/COMPASS complex component CFP-1 and a Sin3S HDAC complex in C. elegans ». Nucleic Acids Research 47, n^o 21 (décembre 2019): 11164‑80. https://dx.doi.org/10.1093/nar/gkz880.
• Bieri, Gregor, Michel Brahic, Luc Bousset, Julien Couthouis, Nicholas J. Kramer, Rosanna Ma, Lisa Nakayama, et al. « LRRK2 Modifies Alpha-Syn Pathology and Spread in Mouse Models and Human Neurons ». Acta Neuropathologica 137, n^o 6 (juin 2019): 961‑80. https://doi.org/10.1007/s00401-019-01995-0.
• Biran, Valérie, Fabrice Decobert, Nathalie Bednarek, Priscilla Boizeau, Jean-François Benoist, Bruno Claustrat, Jérôme Barré, et al. « Melatonin Levels in Preterm and Term Infants and Their Mothers ». International Journal of Molecular Sciences 20, n^o 9 (janvier 2019): 2077. https://doi.org/10.3390/ijms20092077.
• Bokobza, Cindy, Juliette Van Steenwinckel, Shyamala Mani, Valerie Mezger, Bobbi Fleiss, et Pierre Gressens. « Neuroinflammation in Preterm Babies and Autism Spectrum Disorders ». Pediatric Research 85, n^o 2 (janvier 2019): 155‑65. https://doi.org/10.1038/s41390-018-0208-4.
• Bonello, Fiona, Sidi-Mohamed Hassoun, François Mouton-Liger, Yea Seul Shin, Adeline Muscat, Christelle Tesson, Suzanne Lesage, et al. « LRRK2 Impairs PINK1/Parkin-Dependent Mitophagy via Its Kinase Activity: Pathologic Insights into Parkinson’s Disease ». Human Molecular Genetics 28, n^o 10 (15 mai 2019): 1645‑60. https://doi.org/10.1093/hmg/ddz004.
• Bonvento, G. « Glycolysis-Derived L-Serine in Astrocytes Contributes to Spatial Memory ». Glia 67 (juillet 2019): E97‑E97.
• Boutin, Jean A., Frederic Bouillaud, Elzbieta Janda, István Gacsalyi, Gérald Guillaumet, Etienne C. Hirsch, Daniel A. Kane, et al. « S29434, a Quinone Reductase 2 Inhibitor: Main Biochemical and Cellular Characterization ». Molecular Pharmacology 95, n^o 3 (1 mars 2019): 269‑85. https://doi.org/10.1124/mol.118.114231.
• Boutry, Maxime, Alexandre Pierga, Raphael Matusiak, Julien Branchu, Marc Houllegatte, Yoan Ibrahim, Elise Balse, et al. « Loss of Spatacsin Impairs Cholesterol Trafficking and Calcium Homeostasis ». Communications Biology 2 (17 octobre 2019): UNSP 380. https://doi.org/10.1038/s42003-019-0615-z.
• Branzoli, Francesca, Clement Pontoizeau, Lucien Tchara, Anna Luisa Di Stefano, Aurelie Kamoun, Dinesh K. Deelchand, Romain Valabregue, et al. « Cystathionine as a Marker for 1p/19q Codeleted Gliomas by in Vivo Magnetic Resonance Spectroscopy ». Neuro-Oncology 21, n^o 6 (juin 2019): 765‑74. https://doi.org/10.1093/neuonc/noz031.
• Brouillet, Emmanuel, et Karine Merienne. « What Is Gained or ‘Lost in Translation’ in Huntington’s Disease ». Brain 142, n^o 10 (1 octobre 2019): 2900‑2902. https://doi.org/10.1093/brain/awz274.
• Carrillo-de Sauvage, M.-A., R. Pulgar-Sepulveda, S. Vejar, J. Flament, C. Escartin, et F. C. Ortiz. « Contribution of Reactive Astrocytes to Myelin Repair ». Glia 67 (juillet 2019): E446‑47.
• Chali, Farah, Giampaolo Milior, Serge Marty, Melanie Morin-Brureau, Caroline Le Duigou, Etienne Savary, Corinne Blugeon, Laurent Jourdren, et Richard Miles. « Lipid Markers and Related Transcripts during Excitotoxic Neurodegeneration in Kainate-Treated Mice ». European Journal of Neuroscience 50, n^o 1 (juillet 2019): 1759‑78. https://doi.org/10.1111/ejn.14375.
• Chew, Li-Jin, Xiaotian Ming, Brian McEllin, Jeffrey Dupree, Elim Hong, Mackenzie Catron, Melissa Fauveau, Brahim Nait-Oumesmar, et Vittorio Gallo. « Sox17 Regulates a Program of Oligodendrocyte Progenitor Cell Expansion and Differentiation during Development and Repair ». Cell Reports 29, n^o 10 (3 décembre 2019): 3173-+. https://doi.org/10.1016/j.celrep.2019.10.121.
• Coarelli, Giulia, Rebecca Schule, Bart P. C. van de Warrenburg, Peter De Jonghe, Claire Ewenczyk, Andrea Martinuzzi, Matthis Synofzik, et al. « Loss of Paraplegin Drives Spasticity Rather than Ataxia in a Cohort of 241 Patients with SPG7 ». Neurology 92, n^o 23 (4 juin 2019): E2679‑90. https://doi.org/10.1212/WNL.0000000000007606.
• Cobo-Calvo, Alvaro, Xavier Ayrignac, Philippe Kerschen, Philippe Horellou, Francois Cotton, Pierre Labauge, Sandra Vukusic, Kumaran Deiva, Che Serguera, et Romain Marignier. « Cranial Nerve Involvement in Patients with MOG Antibody-Associated Disease ». Neurology-Neuroimmunology & Neuroinflammation 6, n^o 2 (mars 2019): e543. https://doi.org/10.1212/NXI.0000000000000543.
• Cook, Lawrence J., John W. Rose, Jessica S. Alvey, Anna Marie Jolley, Renee Kuhn, Brie Marron, Melissa Pederson, et al. « Collaborative International Research in Clinical and Longitudinal Experience Study in NMOSD ». Neurology-Neuroimmunology & Neuroinflammation 6, n^o 5 (septembre 2019): e583. https://doi.org/10.1212/NXI.0000000000000583.
• Corcoran, Gavin, Paul Korner, Fraser Wright, Thomas Foltynie, Katie Binley, Yatish Lad, Romina Aron Badin, et al. « AXO-Lenti-PD: A Second-Generation Lentiviral Gene Therapy for the Treatment of Parkinson’s Disease ». Molecular Therapy 27, n^o 4 (22 avril 2019): 188‑188.
• Cresto, Noémie, Camille Gardier, Francesco Gubinelli, Marie-Claude Gaillard, Géraldine Liot, Andrew B. West, et Emmanuel Brouillet. « The Unlikely Partnership between LRRK2 and α-Synuclein in Parkinson’s Disease ». European Journal of Neuroscience 0, n^o 0 (14 février 2019). https://doi.org/10.1111/ejn.14182.
• Desban, Laura, Andrew Prendergast, Julian Roussel, Marion Rosello, David Geny, Claire Wyart, et Pierre-Luc Bardet. « Regulation of the Apical Extension Morphogenesis Tunes the Mechanosensory Response of Microvilliated Neurons ». Plos Biology 17, n^o 4 (avril 2019): e3000235. https://doi.org/10.1371/journal.pbio.3000235.
• Doerflinger, Anaëlle, Nam Nguyen Quang, Edmond Gravel, Frédéric Ducongé, et Eric Doris. « Aptamer-decorated polydiacetylene micelles with improved targeting of cancer cells ». International Journal of Pharmaceutics 565 (30 juin 2019): 59‑63. https://doi.org/10.1016/j.ijpharm.2019.04.071.
• dos‐Santos‐Pereira, Mauricio, Franscisco S. Guimarães, Elaine Del‐Bel, Rita Raisman‐Vozari, et Patrick P. Michel. « Cannabidiol Prevents LPS-Induced Microglial Inflammation by Inhibiting ROS/NF-ΚB-Dependent Signaling and Glucose Consumption ». Glia 0, n^o 0 (30 octobre 2019). https://doi.org/10.1002/glia.23738.
• Dubessy, Anne-Laure, Elisa Mazuir, Quentin Rappeneau, Sokounthie Ou, Charly Abi Ghanem, Kevin Piquand, Marie-Stephane Aigrot, et al. « Role of a Contactin Multi-Molecular Complex Secreted by Oligodendrocytes in Nodal Protein Clustering in the CNS ». Glia 67, n^o 12 (décembre 2019): 2248‑63. https://doi.org/10.1002/glia.23681.
• Dubreil, Laurence, Lydie Lagalice, Johan Deniaud, Antoine Sabourin, Claire Lovo, Karim Bey, Juliette Hordeaux, et al. « Assessment of Adeno-Associated Virus Gene Therapies Efficacy on Acid Alpha-Glucosidase Restoration and Glycogen Storage Correction in Cardiac Muscle of Pompe Disease Mice Using Synchrotron Infrared and Ultraviolet Microspectroscopies ». Journal of Spectral Imaging 8 (5 août 2019). https://doi.org/10.1255/jsi.2019.a13.
• Duyckaerts, Charles, Florence Clavaguera, et Marie-Claude Potier. « The Prion-like Propagation Hypothesis in Alzheimer’s and Parkinson’s Disease ». Current Opinion in Neurology 32, n^o 2 (avril 2019): 266‑71. https://doi.org/10.1097/WCO.0000000000000672.
• Escartin, Carole, Océane Guillemaud, et Maria-Angeles Carrillo‐de Sauvage. « Questions and (Some) Answers on Reactive Astrocytes ». Glia 0, n^o 0 (1 octobre 2019). https://doi.org/10.1002/glia.23687.
• Fenyi, Alexis, Laurène Leclair-Visonneau, Thomas Clairembault, Emmanuel Coron, Michel Neunlist, Ronald Melki, Pascal Derkinderen, et Luc Bousset. « Detection of Alpha-Synuclein Aggregates in Gastrointestinal Biopsies by Protein Misfolding Cyclic Amplification ». Neurobiology of Disease 129 (1 septembre 2019): 38‑43. https://doi.org/10.1016/j.nbd.2019.05.002.
• Fleiss, Bobbi, Scott A. Rivkees, et Pierre Gressens. « Early Origins of Neuropsychiatric Disorders ». Pediatric Research 85, n^o 2 (janvier 2019): 113‑14. https://doi.org/10.1038/s41390-018-0225-3.
• Fovet, Claire-Maelle, Lev Stimmer, Vanessa Contreras, Philippe Horellou, Audrey Hubert, Nabila Seddiki, Catherine Chapon, et al. « Intradermal Vaccination Prevents Anti-MOG Autoimmune Encephalomyelitis in Macaques ». Ebiomedicine 47 (septembre 2019): 492‑505. https://doi.org/10.1016/j.ebiom.2019.08.052.
• Garcia-Diaz, Beatriz, Corinne Bachelin, Fanny Coulpier, Gaspard Gerschenfeld, Cyrille Deboux, Violetta Zujovic, Patrick Charnay, Piotr Topilko, et Anne Baron-Van Evercooren. « Blood Vessels Guide Schwann Cell Migration in the Adult Demyelinated CNS through Eph/Ephrin Signaling ». Acta Neuropathologica 138, n^o 3 (septembre 2019): 457‑76. https://doi.org/10.1007/s00401-019-02011-1.
• Gargouri, Fatma, Cécile Gallea, Marie Mongin, Nadya Pyatigorskaya, Romain Valabregue, Claire Ewenczyk, Marie Sarazin, Lydia Yahia‐Cherif, Marie Vidailhet, et Stéphane Lehéricy. « Multimodal Magnetic Resonance Imaging Investigation of Basal Forebrain Damage and Cognitive Deficits in Parkinson’s Disease ». Movement Disorders 0, n^o 0 (8 février 2019). https://doi.org/10.1002/mds.27561.
• Gary, Charlotte, Suzanne Lam, Anne-Sophie Hérard, James E. Koch, Fanny Petit, Pauline Gipchtein, Stephen J. Sawiak, et al. « Encephalopathy induced by Alzheimer brain inoculation in a non-human primate ». Acta Neuropathologica Communications 7, n^o 1 (4 septembre 2019): 126. https://doi.org/10.1186/s40478-019-0771-x.
• Gendron, J., C. Colace-Sauty, N. Beaume, H. Cartonnet, J. Guegan, D. Ulveling, C. Pardanaud-Glavieux, I. Moszer, H. Cheval, et P. Ravassard. « Long Non-Coding RNA Repertoire and Open Chromatin Regions Constitute Midbrain Dopaminergic Neuron - Specific Molecular Signatures ». Scientific Reports 9, n^o 1 (5 février 2019): 1409. https://doi.org/10.1038/s41598-018-37872-1.
• Genin, Emmanuelle C., Blandine Madji Hounoum, Sylvie Bannwarth, Konstantina Fragaki, Sandra Lacas-Gervais, Alessandra Mauri-Crouzet, Francoise Lespinasse, et al. « Mitochondrial Defect in Muscle Precedes Neuromuscular Junction Degeneration and Motor Neuron Death in CHCHD10(S59L/+) Mouse ». Acta Neuropathologica 138, n^o 1 (juillet 2019): 123‑45. https://doi.org/10.1007/s00401-019-01988-z.
• George, Sonia, Nolwen L. Rey, Trevor Tyson, Corinne Esquibel, Lindsay Meyerdirk, Emily Schulz, Steven Pierce, et al. « Microglia Affect Alpha-Synuclein Cell-to-Cell Transfer in a Mouse Model of Parkinson’s Disease ». Molecular Neurodegeneration 14, n^o 1 (16 août 2019): 34. https://doi.org/10.1186/s13024-019-0335-3.
• Georges, Pauline, Maria-Gabriela Boza-Moran, Jacqueline Gide, Georges Arielle Peche, Benjamin Foret, Aurelien Bayot, Pierre Rustin, Marc Peschanski, Cecile Martinat, et Laetitia Aubry. « Induced Pluripotent Stem Cells-Derived Neurons from Patients with Friedreich Ataxia Exhibit Differential Sensitivity to Resveratrol and Nicotinamide ». Scientific Reports 9 (10 octobre 2019): 14568. https://doi.org/10.1038/s41598-019-49870-y.
• Gerhalter, Teresa, Lena V. Gast, Benjamin Marty, Jan Martin, Regina Trollmann, Stephanie Schüssler, Frank Roemer, et al. « 23Na MRI Depicts Early Changes in Ion Homeostasis in Skeletal Muscle Tissue of Patients with Duchenne Muscular Dystrophy ». Journal of Magnetic Resonance Imaging 50, n^o 4 (2019): 1103‑13. https://doi.org/10.1002/jmri.26681.
• Geric, Ivana, Sandra Schoors, Christel Claes, Pierre Gressens, Claudia Verderio, Catherine M. Verfaillie, Paul P. Van Veldhoven, Peter Carmeliet, et Myriam Baes. « Metabolic Reprogramming during Microglia Activation ». Immunometabolism 1, n^o 1 (4 mars 2019). https://doi.org/10.20900/immunometab20190002.
• Gouder, Laura, Aline Vitrac, Hany Goubran-Botros, Anne Danckaert, Jean-Yves Tinevez, Gwenaelle Andre-Leroux, Ekaterina Atanasova, et al. « Altered Spinogenesis in IPSC-Derived Cortical Neurons from Patients with Autism Carrying de Novo SHANK3 Mutations ». Scientific Reports 9 (14 janvier 2019): 94. https://doi.org/10.1038/s41598-018-36993-x.
• Graciarena, Mariana, Araceli Seiffe, Brahim Nait-Oumesmar, et Amaicha M. Depino. « Hypomyelination and Oligodendroglial Alterations in a Mouse Model of Autism Spectrum Disorder ». Frontiers in Cellular Neuroscience 12 (2019). https://doi.org/10.3389/fncel.2018.00517.
• Gribaudo, Simona, Philippe Tixador, Luc Bousset, Alexis Fenyi, Patricia Lino, Ronald Melki, Jean-Michel Peyrin, et Anselme L. Perrier. « Propagation of α-Synuclein Strains within Human Reconstructed Neuronal Network ». Stem Cell Reports, 10 janvier 2019. https://doi.org/10.1016/j.stemcr.2018.12.007.
• Grozdanov, Veselin, Luc Bousset, Meike Hoffmeister, Corinna Bliederhaeuser, Christoph Meier, Karine Madiona, Laura Pieri, et al. « Increased Immune Activation by Pathologic α-Synuclein in Parkinson’s Disease ». Annals of Neurology 86, n^o 4 (2019): 593‑606. https://doi.org/10.1002/ana.25557.
• Guimaraes-Costa, Raquel, Thomas Similowski, Isabelle Rivals, Capucine Morelot-Panzini, Marie-Cecile Nierat, Mai Thao Bui, David Akbar, et al. « Human Diaphragm Atrophy in Amyotrophic Lateral Sclerosis Is Not Predicted by Routine Respiratory Measures ». European Respiratory Journal 53, n^o 2 (1 février 2019): 1801749. https://doi.org/10.1183/13993003.01749-2018.
• Hardy, E., P. Ezan, A.-P. Bemelmans, F. Mouthon, M. Charveriat, N. Rouach, et A. Rancillac. « Impact of Connexine 30 Overexpression on Astroglial and Neuronal Networks ». Glia 67 (juillet 2019): E377‑78.
• Hoch, Lucile, Sara F. Henriques, Celine Bruge, Justine Marsolier, Manon Benabides, Nathalie Bourg, Johana Tournois, et al. « Identification of Thiostrepton as a Pharmacological Approach to Rescue Misfolded Alpha-Sarcoglycan Mutant Proteins from Degradation ». Scientific Reports 9, n^o 1 (6 mai 2019): 1‑15. https://doi.org/10.1038/s41598-019-43399-w.
• Jacoupy, M., E. Hamon-Keromen, A. Ordureau, Z. Erpapazoglou, F. Coge, J.-C. Corvol, O. Nosjean, et al. « The PINK1 Kinase-Driven Ubiquitin Ligase Parkin Promotes Mitochondrial Protein Import through the Presequence Pathway in Living Cells ». Scientific Reports 9 (14 août 2019): 11829. https://doi.org/10.1038/s41598-019-47352-9.
• Jacquemot, Charlotte, Christophe Lalanne, Agnès Sliwinski, Page Piccinini, Emmanuel Dupoux, et Anne-Catherine Bachoud-Lévi. « Improving Language Evaluation in Neurological Disorders: The French Core Assessment of Language Processing (CALAP) ». Psychological Assessment, 10 janvier 2019. https://doi.org/10.1037/pas0000683.
• Jeljeli, Mohamed, Valérie Guérin-El Khourouj, Béatrice Pédron, Pierre Gressens, Olivier Sibony, et Ghislaine Sterkers. « Ontogeny of Cytokine Responses to PHA from Birth to Adulthood ». Pediatric Research 86, n^o 1 (juillet 2019): 63‑70. https://doi.org/10.1038/s41390-019-0383-y.
• Kamimura, Hermes A. S., Julien Flament, Julien Valette, Andrea Cafarelli, Romina Aron Badin, Philippe Hantraye, et Benoit Larrat. « Feedback Control of Microbubble Cavitation for Ultrasound-Mediated Blood-Brain Barrier Disruption in Non-Human Primates under Magnetic Resonance Guidance ». Journal of Cerebral Blood Flow and Metabolism 39, n^o 7 (juillet 2019): 1191‑1203. https://doi.org/10.1177/0271678X17753514.
• Kawahata, Ichiro, Luc Bousset, Ronald Melki, et Kohji Fukunaga. « Fatty Acid-Binding Protein 3 Is Critical for Alpha-Synuclein Uptake and MPP+-Induced Mitochondrial Dysfunction in Cultured Dopaminergic Neurons ». International Journal of Molecular Sciences 20, n^o 21 (novembre 2019): 5358. https://doi.org/10.3390/ijms20215358.
• Khan, Zakir, Elouan Terrien, Florent Delhommel, Cynthia Lefebvre-Omar, Delphine Bohl, Sandrine Vitry, Clara Bernard, et al. « Structure-Based Optimization of a PDZ-Binding Motif within a Viral Peptide Stimulates Neurite Outgrowth ». Journal of Biological Chemistry 294, n^o 37 (13 septembre 2019): 13755‑68. https://doi.org/10.1074/jbc.RA119.008238.
• Killinger, Bryan A., Ronald Melki, Patrik Brundin, et Jeffrey H. Kordower. « Endogenous Alpha-Synuclein Monomers, Oligomers and Resulting Pathology: Let’s Talk about the Lipids in the Room ». Npj Parkinsons Disease 5 (12 novembre 2019): 23. https://doi.org/10.1038/s41531-019-0095-3.
• Lavisse, Sonia, Susannah Williams, Sophie Lecourtois, Nadja van Camp, Martine Guillermier, Pauline Gipchtein, Caroline Jan, et al. « Longitudinal Characterization of Cognitive and Motor Deficits in an Excitotoxic Lesion Model of Striatal Dysfunction in Non-Human Primates ». Neurobiology of Disease 130 (1 octobre 2019): 104484. https://doi.org/10.1016/j.nbd.2019.104484.
• Le Roux, Gwenaelle, Rafika Jarray, Anne-Cecile Guyot, Serena Pavoni, Narciso Costa, Frederic Theodoro, Ferid Nassor, et al. « Proof-of-Concept Study of Drug Brain Permeability Between in Vivo Human Brain and an in Vitro IPSCs-Human Blood-Brain Barrier Model ». Scientific Reports 9 (5 novembre 2019): 16310. https://doi.org/10.1038/s41598-019-52213-6.
• Levy, Jonathan, Patricia Facchinetti, Caroline Jan, Mélyna Achour, Clément Bouvier, Jean-François Brunet, Thierry Delzescaux, et François Giuliano. « Tridimensional Mapping of Phox2b Expressing Neurons in the Brainstem of Adult Macaca Fascicularis and Identification of the Retrotrapezoid Nucleus ». Journal of Comparative Neurology 527, n^o 17 (2019): 2875‑84. https://doi.org/10.1002/cne.24713.
• Ligneul, Clémence, Marco Palombo, Edwin Hernández-Garzón, María-Angeles Carrillo-de Sauvage, Julien Flament, Philippe Hantraye, Emmanuel Brouillet, Gilles Bonvento, Carole Escartin, et Julien Valette. « Diffusion-Weighted Magnetic Resonance Spectroscopy Enables Cell-Specific Monitoring of Astrocyte Reactivity in Vivo ». NeuroImage 191 (1 mai 2019): 457‑69. https://doi.org/10.1016/j.neuroimage.2019.02.046.
• Loera-Valencia, R., A. Cedazo-Minguez, P. A. Kenigsberg, G. Page, A. Duarte, P. Giusti, M. Zusso, et al. « Current and Emerging Avenues for Alzheimer’s Disease Drug Targets ». Journal of Internal Medicine 286, n^o 4 (octobre 2019): 398‑437. https://doi.org/10.1111/joim.12959.
• Maatouk, Layal, Chenju Yi, Maria-Angeles Carrillo-de Sauvage, Anne-Claire Compagnion, Stephane Hunot, Pascal Ezan, Etienne C. Hirsch, et al. « Glucocorticoid Receptor in Astrocytes Regulates Midbrain Dopamine Neurodegeneration through Connexin Hemichannel Activity ». Cell Death and Differentiation 26, n^o 3 (février 2019): 580‑96. https://doi.org/10.1038/s41418-018-0150-3.
• Mairesse, Jérôme, Manuela Zinni, Julien Pansiot, Rahma Hassan-Abdi, Charlie Demene, Marina Colella, Christiane Charriaut-Marlangue, et al. « Oxytocin receptor agonist reduces perinatal brain damage by targeting microglia ». Glia 67, n^o 2 (1 février 2019): 345‑59. https://doi.org/10.1002/glia.23546.
• Martin, Elodie, Majid Amar, Carine Dalle, Ihsen Youssef, Celine Boucher, Caroline Le Duigou, Matthias Brueckner, et al. « New Role of P2X7 Receptor in an Alzheimer’s Disease Mouse Model ». Molecular Psychiatry 24, n^o 1 (janvier 2019): 108‑25. https://doi.org/10.1038/s41380-018-0108-3.
• Martinello, Kathryn A., Christopher Meehan, Adnan Avdic-Belltheus, Ingran Lingam, Sara Ragab, Mariya Hristova, Cally J. Tann, et al. « Acute LPS Sensitization and Continuous Infusion Exacerbates Hypoxic Brain Injury in a Piglet Model of Neonatal Encephalopathy ». Scientific Reports 9, n^o 1 (15 juillet 2019): 1‑17. https://doi.org/10.1038/s41598-019-46488-y.
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• Mimouna, Safa Ben, Tifenn Le Charpentier, Sophie Lebon, Juliette Van Steenwinckel, Imed Messaoudi, et Pierre Gressens. « Involvement of the Synapse-Specific Zinc Transporter ZnT3 in Cadmium-Induced Hippocampal Neurotoxicity ». Journal of Cellular Physiology 234, n^o 9 (2019): 15872‑84. https://doi.org/10.1002/jcp.28245.
• Nadkarni, Nachiket A., Salma Bougacha, Clément Garin, Marc Dhenain, et Jean-Luc Picq. « A 3D Population-Based Brain Atlas of the Mouse Lemur Primate with Examples of Applications in Aging Studies and Comparative Anatomy ». NeuroImage 185 (15 janvier 2019): 85‑95. https://doi.org/10.1016/j.neuroimage.2018.10.010.
• Nair, Syam, Kristina S. Sobotka, Pooja Joshi, Pierre Gressens, Bobbi Fleiss, Claire Thornton, Carina Mallard, et Henrik Hagberg. « Lipopolysaccharide-Induced Alteration of Mitochondrial Morphology Induces a Metabolic Shift in Microglia Modulating the Inflammatory Response in Vitro and in Vivo ». Glia 67, n^o 6 (2019): 1047‑61. https://doi.org/10.1002/glia.23587.
• Nguyen, Quang Tuan Rémy, Alban Gravier, Constance Lesoil, Alexandre Bedet, Camille Petit-Hoang, Matthieu Mahevas, Armand Mekontso-Dessap, Jérôme Hodel, Anne-Catherine Bachoud-Lévi, et Laurent Cleret de Langavant. « Acute Hippocampal Encephalopathy in Heavy Cannabis Users: About 2 Cases ». The American Journal of Medicine, 24 décembre 2019. https://doi.org/10.1016/j.amjmed.2019.11.018.
• Nóbrega, Clévio, Liliana Mendonça, Adriana Marcelo, Antonin Lamazière, Sandra Tomé, Gaetan Despres, Carlos A. Matos, et al. « Restoring Brain Cholesterol Turnover Improves Autophagy and Has Therapeutic Potential in Mouse Models of Spinocerebellar Ataxia ». Acta Neuropathologica, 14 juin 2019. https://doi.org/10.1007/s00401-019-02019-7.
• Orefice, Nicola Salvatore, Benoît Souchet, Jérôme Braudeau, Sandro Alves, Françoise Piguet, Fanny Collaud, Giuseppe Ronzitti, et al. « Real-Time Monitoring of Exosome Enveloped-AAV Spreading by Endomicroscopy Approach: A New Tool for Gene Delivery in the Brain ». Molecular Therapy - Methods & Clinical Development 14 (13 septembre 2019): 237‑51. https://doi.org/10.1016/j.omtm.2019.06.005.
• Ortiz, Fernando C., Chloe Habermacher, Mariana Graciarena, Pierre-Yves Houry, Akiko Nishiyama, Brahim Nait Oumesmar, et Maria Cecilia Angulo. « Neuronal Activity in Vivo Enhances Functional Myelin Repair ». Jci Insight 4, n^o 9 (2 mai 2019): e123434. https://doi.org/10.1172/jci.insight.123434.
• Ounissi, Marwa, Christelle Rodrigues, Hugues Bienayme, Paul Duhamel, Gérard Pons, Olivier Dulac, Rima Nabbout, Catherine Chiron, et Vincent Jullien. « Proposition of a Minimal Effective Dose of Vigabatrin for the Treatment of Infantile Spasms Using Pediatric and Adult Pharmacokinetic Data ». The Journal of Clinical Pharmacology 59, n^o 2 (2019): 177‑88. https://doi.org/10.1002/jcph.1309.
• Penaud-Budloo, Magalie, Frédéric Broucque, Katell Harrouet, Mohammed Bouzelha, Sylvie Saleun, Sandy Douthe, Susan D’Costa, et al. « Stability of the Adeno-Associated Virus 8 Reference Standard Material ». Gene Therapy 26, n^o 5 (mai 2019): 211‑15. https://doi.org/10.1038/s41434-019-0072-9.
• Peralta Ramos, Javier María, Pablo Iribarren, Luc Bousset, Ronald Melki, Veerle Baekelandt, et Anke Van der Perren. « Peripheral Inflammation Regulates CNS Immune Surveillance Through the Recruitment of Inflammatory Monocytes Upon Systemic α-Synuclein Administration ». Frontiers in Immunology 10 (2019). https://doi.org/10.3389/fimmu.2019.00080.
• Petiet, Alexandra, Isaac Adanyeguh, Marie-Stéphane Aigrot, Emilie Poirion, Brahim Nait‐Oumesmar, Mathieu Santin, et Bruno Stankoff. « Ultrahigh Field Imaging of Myelin Disease Models: Toward Specific Markers of Myelin Integrity? » Journal of Comparative Neurology 527, n^o 13 (2019): 2179‑89. https://doi.org/10.1002/cne.24598.
• Pifferi, Fabien, Jérémy Terrien, Martine Perret, Jacques Epelbaum, Stéphane Blanc, Jean-Luc Picq, Marc Dhenain, et Fabienne Aujard. « Promoting Healthspan and Lifespan with Caloric Restriction in Primates ». Communications Biology 2, n^o 1 (15 mars 2019): 107. https://doi.org/10.1038/s42003-019-0348-z.
• Regent, Florian, Lise Morizur, Léa Lesueur, Walter Habeler, Alexandra Plancheron, Karim Ben M’Barek, et Christelle Monville. « Automation of Human Pluripotent Stem Cell Differentiation toward Retinal Pigment Epithelial Cells for Large-Scale Productions ». Scientific Reports 9, n^o 1 (23 juillet 2019): 1‑11. https://doi.org/10.1038/s41598-019-47123-6.
• Reilmann, Ralf, Andrew McGarry, Igor D. Grachev, Juha-Matti Savola, Beth Borowsky, Eli Eyal, Nicholas Gross, et al. « Safety and Efficacy of Pridopidine in Patients with Huntington’s Disease (PRIDE-HD): A Phase 2, Randomised, Placebo-Controlled, Multicentre, Dose-Ranging Study ». Lancet Neurology 18, n^o 2 (février 2019): 165‑76. https://doi.org/10.1016/S1474-4422(18)30391-0.
• Rey, Nolwen L., Luc Bousset, Sonia George, Zachary Madaj, Lindsay Meyerdirk, Emily Schulz, Jennifer A. Steiner, Ronald Melki, et Patrik Brundin. « Alpha-Synuclein Conformational Strains Spread, Seed and Target Neuronal Cells Differentially after Injection into the Olfactory Bulb ». Acta Neuropathologica Communications 7, n^o 1 (30 décembre 2019): 221. https://doi.org/10.1186/s40478-019-0859-3.
• Reyngoudt, Harmen, Alfredo L. Lopez Kolkovsky, et Pierre G. Carlier. « Free Intramuscular Mg2+ Concentration Calculated Using Both 31P and 1H NMRS-Based PH in the Skeletal Muscle of Duchenne Muscular Dystrophy Patients ». NMR in Biomedicine 32, n^o 9 (2019): e4115. https://doi.org/10.1002/nbm.4115.
• Rodrigues, Christelle, Catherine Chiron, Marwa Ounissi, Olivier Dulac, Ségolène Gaillard, Rima Nabbout, et Vincent Jullien. « Pharmacokinetic evaluation of vigabatrin dose for the treatment of refractory focal seizures in children using adult and pediatric data ». Epilepsy Research 150 (1 février 2019): 38‑45. https://doi.org/10.1016/j.eplepsyres.2019.01.002.
• Serguera, Che, Lev Stimmer, Claire-Maelle Fovet, Philippe Horellou, Vanessa Contreras, Nicolas Tchitchek, Julie Massonneau, et al. « Anti-MOG autoantibodies pathogenicity in children and macaques demyelinating diseases ». Journal of Neuroinflammation 16, n^o 1 (30 novembre 2019): 244. https://doi.org/10.1186/s12974-019-1637-7.
• Shrivastava, Amulya Nidhi, Virginie Redeker, Laura Pieri, Luc Bousset, Marianne Renner, Karine Madiona, Caroline Mailhes‐Hamon, et al. « Clustering of Tau Fibrils Impairs the Synaptic Composition of Α3‐Na+/K+‐ATPase and AMPA Receptors ». The EMBO Journal, 8 janvier 2019, e99871. https://doi.org/10.15252/embj.201899871.
• Souchet, Benoit, Mickael Audrain, Jean Marie Billard, Julien Dairou, Romain Fol, Nicola Salvatore Orefice, Satoru Tada, et al. « Inhibition of DYRK1A Proteolysis Modifies Its Kinase Specificity and Rescues Alzheimer Phenotype in APP/PS1 Mice ». Acta Neuropathologica Communications 7 (18 mars 2019): 46. https://doi.org/10.1186/s40478-019-0678-6.
• Stolp, Helen B., Bobbi Fleiss, Yoko Arai, Veena Supramaniam, Regina Vontell, Sebastian Birtles, Abi G. Yates, et al. « Interneuron Development Is Disrupted in Preterm Brains With Diffuse White Matter Injury: Observations in Mouse and Human ». Frontiers in Physiology 10 (2019). https://doi.org/10.3389/fphys.2019.00955.
• Tepavcevic, V., G. Dufayet-Chaffaud, M.-S. Aigrot, B. Gillet-Legrand, S. Tada, N. Cartier, et C. Lubetzki. « Enhancing CNS Remyelination by Means of Haematopoietic Stem Cell Transplantation and Gene Therapy ». Multiple Sclerosis Journal 25 (septembre 2019): 675‑675.
• Tournier, Nicolas, Martin Bauer, Verena Pichler, Lukas Nics, Eva-Maria Klebermass, Karsten Bamminger, Peter Matzneller, et al. « Impact of P-Glycoprotein Function on the Brain Kinetics of the Weak Substrate 11C-Metoclopramide Assessed with PET Imaging in Humans ». Journal of Nuclear Medicine 60, n^o 7 (7 janvier 2019): 985‑91. https://doi.org/10.2967/jnumed.118.219972.
• Ullio-Gamboa, Gabriela, Kenea C Udobi, Sophie Dezard, Marla K Perna, Keila N Miles, Narciso Costa, Frédéric Taran, et al. « Dodecyl creatine ester-loaded nanoemulsion as a promising therapy for creatine transporter deficiency ». Nanomedicine, 30 avril 2019. https://doi.org/10.2217/nnm-2019-0059.
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Join us for the open session of the HOPE 2020 congress on Thursday, January 30, 2020 at ICM from 6PM ! An inspiring overview of new surgical techniques for Parkinson patients by Professor Stéphane PALFI, a testimony by a patient-expert, more about brain donation and its usefulness for researchers by professor Charles DUYCKAERTS, ...

The second edition of the "pHysiopathology of Parkinson's DisEase" (HOPE) conference will be held from 29 to 31 January 2020 at ICM in Paris.

Following the success of the first edition and the very stimulating feedback from participants regarding the latest scientific advances and the integration of basic research into clinical research, we are pleased to invite you to take part in this second edition.

The topics will cover the epigenetic and genetic determinants of Parkinson's disease, their molecular mechanisms and their modelling, in order to better understand the pathophysiology of Parkinson's disease and open pre-clinical, clinical and imaging perspectives.

In addition we propose a workshop the first day on two topics that will be discussed later on during the congress

1) Cellular modelling using microfluidic and stem cell technologies

2) Available imaging tools for cellular models and to humans

Submission and registrations are available on the conference website: https://hope2020.sciencesconf.org/

Submission deadline: December 1^st, 2019

Registration deadline: January 12, 2020

If you would like to contribute to the organization of this event, we are happily welcoming sponsorship: https://hope2020.sciencesconf.org/resource/sponsors

EATRIS is running a series of webinars in the fall of this year, looking at reproducibility issues experienced during specific phases of the drug development pipeline (screening, preclinical models, biomarker development & analytical platforms, clinical validation). These webinars are developed in close collaboration with other Research Infrastructures (EU-OPENSCREEN, INFRAFRONTIER, BBMRI, ECRIN) and initiatives such as Translation Together.

The webinars will be brought to you by experts in the field and include an audience Q&A session during which attendees can ask questions at the end of the lecture. All webinars will be recorded and available for later viewing.

For more information and registration: https://eatris.eu/insights/webinar-series-quality-reproducibility-issues-drug-development/

NeurATRIS is pleased to announce that the ‘EATRIS-Plus’ proposal has been funded by the European Commission under the INFRADEV-3 call, which concerns the development and long sustainability of new pan-European research infrastructures. 

NeurATRIS, as EATRIS French node, is one of 19 partners in the four-year project. The project aims to build capabilities and deliver innovative scientific tools to support the long-term sustainability of EATRIS as one of Europe’s key research infrastructures.

Title of proposal: EATRIS-Plus – Consolidating the capacities of EATRIS-ERIC for personalised medicine

Start date: 2020 (precise date to be confirmed)

Duration: 48 months

EATRIS is happy to present the Annual Report for 2018, the fifth year of active operations for EATRIS ERIC. You will learn about the year’s highlights and notable milestones, presented in a more personal format, told by the passionate advocates of Translational Medicine in EATRIS.

The Iseult project magnet being installed at Neurospin (CEA Paris-Saclay) reached a nominal magnetic field of 11.7 teslas (T) on July 18, 2019. This is a world record for a whole-body magnetic resonance imager (MRI) magnet, the culmination of years of R&D and at the forefront of innovation in the field of superconducting magnets. Over the coming months, the equipment required for neuroimaging will be installed around the magnet and in its central tube to create a human MRI scanner capable of examining the brain more accurately than ever before, in the interest of fundamental research, cognitive sciences and diagnosing neurodegenerative diseases.

Find out more here: http://www.cea.fr/english/Pages/News/Iseult-MRI-Magnet-Record.aspx

The second edition of the "pHysiopathology of Parkinson's DisEase" (HOPE) conference, co-organized by NeurATRIS, will be held from 29 to 31 January 2020 at ICM in Paris.

Following the success of the first edition and the very stimulating feedback from participants regarding the latest scientific advances and the integration of basic research into clinical research, we are pleased to invite you to take part in this second edition.

The topics will cover the epigenetic and genetic determinants of Parkinson's disease, their molecular mechanisms and their modelling, in order to better understand the pathophysiology of Parkinson's disease and open pre-clinical, clinical and imaging perspectives.

In addition we propose a workshop the first day on two topics that will be discussed later on during the congress

1)      Cellular modelling using microfluidic and stem cell technologies

2)      Available imaging tools for cellular models and to humans

The definitive program and registrations will soon be available on the conference website: https://hope2020.sciencesconf.org/

Spinocerebellar ataxias are genetic neurodegenerative diseases of the cerebellum and brainstem causing numerous motor disorders, for which no curative or preventive therapies are available. SCA3 or Machado-Joseph disease (MJD) is the most prevalent ataxia worldwide. In their work published on June 14 in Acta Neuropathologica, Nathalie Cartier-Lacave, researcher from Inserm at the Brain and Spine Institute and NeurATRIS member, and her team have discovered the crucial role of an enzyme allowing to alleviate symptoms of the disease in mice.

Read the complete press release on the ICM website (in French): https://icm-institute.org/fr/actualite/nouvelle-cible-therapeutique-traiter-ataxies-spinocerebelleuses/

Scientific Publication:

RESTORING BRAIN CHOLESTEROL TURNOVER IMPROVES AUTOPHAGY AND HAS THERAPEUTIC POTENTIAL IN MOUSE MODELS OF SPINOCEREBELLAR ATAXIA.

Nóbrega C, Mendonça L, Marcelo A, Lamazière A, Tomé S, Despres G, Matos CA, Mechmet F, Langui D, den Dunnen W, de Almeida LP, Cartier N, Alves S.

Acta Neuropathol. 2019 Jun 14.

Two researchers members of NeurATRIS, Catherine Lubetzki and Bernard Zalc, talked about research and therapy progress on multiple sclerosis on Monday, June 17, 2019 on the radio France Culture (in French).

The research infrastructures NeurATRIS and EATRIS offered on April 17 and May 6, 2019 two webinars dedicated to biological and technological tools for translational research on neurodegenerative diseases: in vivo preclinical models, jointly organized with the infrastructure Celphedia, and ultra high field MRI and MRS, jointly organized with the infrastructure France Life Imaging.

Watch the videos online: https://eatris.eu/solutions/transmedacademy/

The next NeuroFrance conference will take place at Parc Chanot, in Marseille, on May 22-24, 2019, with the support of NeurATRIS. Meet us on our booth or during the sessions specifically supported by NeurATRIS and co-organized by its members: "Shaping and imaging CNS myelin" on May 22 11AM-1PM and "Development and heterogeneity of primary brain tumors" on May 24 3:30-5:30PM.

Find out more : https://www.neurosciences.asso.fr/V2/colloques/SN19/

The Young Researchers in Life Sciences congress (YRLS) 2019 edition will take place on June 4-6, 2019 at Institut Imagine in Paris, with the support of NeurATRIS. 

Co-organized by several leading research institutes in France, the YRLS conference welcomes each year more than 200 attendees from several countries. Its brings together young scientists from various fields and backgrounds allowing them to present their ongoing work, exchange ideas, learn from experts and build new collaborations. The conference features an interactive program that includes posters, talks and round tables designed for young researchers. The wide variety of represented disciplines and topics allows attendees to deepen their knowledge of their research field while broadening their horizons.

During this edition foccussed on 3 broad themes: "Decode. Innovate. Unravel.", Ali Aït-Ikhlef, NeurATRIS partnership manager, will briefly present the infrastructure and its interest for young researchers.

More information and registration: http://yrls.fr/

We are pleased to announce that EATRIS and NeurATRIS are launching a second series of webinars on neurodegenerative diseases in April-May of this year. The series will cover the usage of biological and technological tools such as preclinical models or ultra high field MRI in neurodegenerative diseases and their potential application in translational medicine. These webinars will be brought to you by experts in the field, each time in collaboration with a specialized European Research Infrastructure.

All webinars are free of charge. The webinars include an audience Q&A session during which attendees can ask questions at the end of the lecture. Please note that all webinars will be recorded and available for later viewing.

The first session of this series took place on April 17th at 11:00 AM and was jointly animated by EATRIS, NeurATRIS and Celphedia.

The second session will take place on May 6th at 11:00 AM and will be jointly animated by EATRIS, NeurATRIS and France Life Imaging.

In 2018, NeurATRIS published its research in 96 peer-reviewed scientific journals.

• Adanyeguh, Isaac M., Marie-Lorraine Monin, Daisy Rinaldi, Léorah Freeman, Alexandra Durr, Stéphane Lehéricy, Pierre-Gilles Henry, et Fanny Mochel. « Expanded Neurochemical Profile in the Early Stage of Huntington Disease Using Proton Magnetic Resonance Spectroscopy ». NMR in Biomedicine 31, n^o 3 (2018): e3880. https://doi.org/10.1002/nbm.3880.
• Akwa, Y., E. Gondard, A. Mann, E. Capetillo-Zarate, E. Alberdi, C. Matute, S. Marty, et al. « Synaptic Activity Protects against AD and FTD-like Pathology via Autophagic-Lysosomal Degradation ». Molecular Psychiatry 23, n^o 6 (juin 2018): 1530‑40. https://doi.org/10.1038/mp.2017.142.
• Androuin, Alexandre, Brigitte Potier, U. Valentin Nägerl, Daniel Cattaert, Lydia Danglot, Manon Thierry, Ihsen Youssef, et al. « Evidence for Altered Dendritic Spine Compartmentalization in Alzheimer’s Disease and Functional Effects in a Mouse Model ». Acta Neuropathologica 135, n^o 6 (1 juin 2018): 839‑54. https://doi.org/10.1007/s00401-018-1847-6.
• Audrain, Mickael, Benoit Souchet, Sandro Alves, Romain Fol, Arthur Viode, Alexis Haddjeri, Satoru Tada, et al. « ΒAPP Processing Drives Gradual Tau Pathology in an Age-Dependent Amyloid Rat Model of Alzheimer’s Disease ». Cerebral Cortex 28, n^o 11 (1 novembre 2018): 3976‑93. https://doi.org/10.1093/cercor/bhx260.
• Auvity, Sylvain, Fabien Caillé, Solène Marie, Catriona Wimberley, Martin Bauer, Oliver Langer, Irène Buvat, Sébastien Goutal, et Nicolas Tournier. « P-Glycoprotein (ABCB1) Inhibits the Influx and Increases the Efflux of 11C-Metoclopramide Across the Blood–Brain Barrier: A PET Study on Nonhuman Primates ». Journal of Nuclear Medicine 59, n^o 10 (10 janvier 2018): 1609‑15. https://doi.org/10.2967/jnumed.118.210104.
• Azabou, E., B. Rohaut, R. Porcher, N. Heming, S. Kandelman, J. Allary, G. Moneger, et al. « Mismatch Negativity to Predict Subsequent Awakening in Deeply Sedated Critically Ill Patients ». British Journal of Anaesthesia 121, n^o 6 (décembre 2018): 1290‑97. https://doi.org/10.1016/j.bja.2018.06.029.
• Balbastre, Yaël, Denis Rivière, Nicolas Souedet, Clara Fischer, Anne-Sophie Hérard, Susannah Williams, Michel E. Vandenberghe, et al. « A Validation Dataset for Macaque Brain MRI Segmentation ». Data in Brief 16 (février 2018): 37‑42. https://doi.org/10.1016/j.dib.2017.11.008.
• Barros, L. Felipe, Juan P. Bolaños, Gilles Bonvento, Anne-Karine Bouzier‐Sore, Angus Brown, Johannes Hirrlinger, Sergey Kasparov, et al. « Current Technical Approaches to Brain Energy Metabolism ». Glia 66, n^o 6 (2018): 1138‑59. https://doi.org/10.1002/glia.23248.
• Bassez, Guillaume, Etienne Audureau, Jean-Yves Hogrel, Raphaelle Arrouasse, Sandrine Baghdoyan, Hamza Bhugaloo, Marie-Laurence Gourlay-Chu, Philippe Le Corvoisier, et Marc Peschanski. « Improved Mobility with Metformin in Patients with Myotonic Dystrophy Type 1: A Randomized Controlled Trial ». Brain 141 (octobre 2018): 2855‑65. https://doi.org/10.1093/brain/awy231.
• Bayen, Eleonore, Katherine L. Possin, Yingjia Chen, Laurent Cleret de Langavant, et Kristine Yaffe. « Prevalence of Aging, Dementia, and Multimorbidity in Older Adults With Down Syndrome ». Jama Neurology 75, n^o 11 (novembre 2018): 1399‑1406. https://doi.org/10.1001/jamaneurol.2018.2210.
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The Biobanking and BioMolecular resources Research Infrastructure (BBMRI), the European Research Infrastructure for Translational Medicine (EATRIS) and the European Clinical Research Infrastructure Network (ECRIN) signed an agreement last week in Brussels to build a long-term sustainable collaboration strategy. The agreement lays the ground for facilitating user access to pan-European medical research  infrastructures and supporting the development of tools, joint services and common approaches on quality, standards and advocacy. As a result, the agreement will empower BBMRI, EATRIS and ECRIN to provide even better services to the biomedical community and to support a more costeffective research and development process.

Benoît Larrat, researcher at Neurospin and member of NeurATRIS, is one of the 11 laureates 2018 of the Fondation Alzheimer with the TADUS project - Treating Alzheimer's Disease with Ultrasound.

More information about the project here.

Researchers from SEPIA (François Jacob Institute of Biology) and CellTechs (Sup'Biotech engineering school), working in partnership with LEMM (Frédéric Joliot Institute for Life Sciences), all within or affiliated with the CEA, have developed a new approach for modeling Alzheimer's disease in vitro using human induced pluripotent stem cells (iPSCs). Their work builds upon the ability of iPSCs to differentiate into "mini-brains", that is, three-dimensional cellular structures recapitulating human brain development. 

The propagation of tau assemblies in the brain contributes to the progression of Alzheimer’s disease. Researchers from NeurATRIS, at the Neurodegenerative Diseases Laboratory: mechanisms, therapies, imaging (CNRS/CEA/Université Paris-Sud, MIRCen), working in collaboration with the Ecole Normale Supérieure, Sorbonne University and Inserm, have just identified the targets of these assemblies. Published in the EMBO Journal on January 10, 2019, this work will enable the development of tools capable of blocking these key elements of aggregate propagation and thus combating their pathological effect.

Read the complete press release on the CEA website.

EATRIS and NEURATRIS have joined forces in organizing a series of webinars on Neuroimaging in November 2018, covering the usage of CEST-MRI, optical and PET imaging in neurodegenerative diseases and their potential application in translational medicine. 

The sessions are recorded and made available for those that want to view or share the webinar with colleagues. 

We are pleased  to inform you that the NeurATRIS- EATRIS Webinar on CEST-MRI in neurodegenerative diseases, delivered by Julien Flament, is now available for viewing on Youtube and via EATRIS Transmedacademy website.

EATRIS-ERIC got a nice feature today in Health Europa, UK-based publication covering EU health policy. Read it here !

After a successful first edition (https://translational-neuroscience.b2match.io/), NeurATRIS and Medicen Paris Région are very happy to invite you to join the second edition of “Translational neuroscience: challenges and opportunities”, on January 25, 2019, in Paris.

Gathering experts in neurodegenerative diseases, this event will foster interactions between researchers, clinicians, biotech and pharmaceutical companies.

You will be able to:

• Meet researchers and clinicians with cutting edge expertise in translational research in neurodegenerative diseases
• Hear KOLs from academia and industry in a round table session onBiocollections and clinical data accessibility and sharing
• Share your assets and needs in a flash during a pitch session
• Build R&D collaborative projects during a matchmaking session

Online registration is free and mandatory before January 15: https://translational-neuroscience-2019.b2match.io/  

We are looking forward to seeing you there !

The 2018 EATRIS Combined Platform Meeting will be held in Ljubljana on December 11th and 12th. Like in previous years, the Platform Combined Meeting will be the moment to discuss the EATRIS platform activities and future strategies together, providing formidable networking opportunities. This year the Platform Combined Meeting will also be followed by a two-day CORBEL open workshop on the theme of public-private collaboration. This 2-day event on 12th and 13th December 2018 (back to back with the Combined EATRIS Platform meeting in Ljubljana) will focus on all relevant aspects of setting up such collaborations, from initial contacts through planning and negotiation to completion of legal agreements and project implementation.

NeurATRIS will be present, and we would be very happy to meet you there !

https://eatris.eu/events/eatris-combined-platform-meeting/