Henri Mondor Hospital - UPEC

The Henri Mondor Hospital - UPEC node, headed by Professors Bachoud-Lévi and Remy, is dedicated to translational research for patients suffering from neurodegenerative diseases, in particular Huntington's disease (HD) and Parkinson's disease (PD).

The activity of the node mainly concerns
  • the implementation of clinical phases of biotherapy programmes,
  • the development of new tools to evaluate therapeutic strategies in a cost-effective manner and
  • the identification of prognostic and predictive (bio)markers.

The Assistance Publique - Hôpitaux de Paris (AP-HP), to which Henri-Mondor Hospital is attached, is the largest health care and hospitalisation institution in France. As the leading university hospital in France and the leading producer of scientific publications, AP-HP conducts research to constantly improve care and introduce new treatments.

Within Henri Mondor Hospital, the Neurology Department, headed by Prof. A.C. Bachoud-Lévi, includes the French National Reference Centre for Huntington's disease (https://huntington.aphp.fr/) as well as four expert centres, including the Parkinson's disease centre, headed by Prof. P. Remy and a member of the NS-Park national network dedicated to French therapeutic research projects  (https://parkinson.network/en).

More than 600 Huntington's patients and 1,700 Parkinson's patients are followed annually in the Neurology Department, which is supported by a clinical investigation centre, a technical platform for neurophysiological exploration and brain imaging, a Biological Resource Centre with more than 40,000 samples from MH patients, as well as a Clinical Research Unit for the regulatory follow-up of studies and their statistical analysis.

The department has extensive experience in clinical trials, notably through the coordination for France of the phase III clinical trial on HD gene inhibition (Roche, NCT03761849), the management of the international Multicentric intra-Cerebral Grafting trial in HD (NCT00190450) and its participation in the global HD platform "Enroll".

The Université Paris-Est Créteil (UPEC) is a major player in the dissemination of academic, scientific and technological culture and trains more than 40,000 students each year. UPEC favours a cross-disciplinary approach to meet public health challenges. Research is supported by 8 Joint Research Units (UMR) including the Mondor Institute of Biomedical Research (https://www.imrb.inserm.fr/en/) (IMRB), created in 2009. It is one of the main biomedical research centres in the eastern part of the Ile-de-France region, with a national and international reputation. The research teams develop high-level translational research in a wide variety of innovative fields, in direct liaison with healthcare services and a large number of patient cohorts. The IMRB also offers technological platforms (https://www.imrb.inserm.fr/en/plateforms/) that are accessible to the research community and the business world.

Pr Anne-Catherine Bachoud-Lévi (MD, PhD) (h index = 52, May 2022) is the head of the Neurology Department at Henri Mondor Hospital, coordinates the French National Reference Centre for Huntington's disease (CRMR DGOS), the Plateforme Maladies Rares Grand Paris Est and coordinates the Huntington’s Chorea disease working group of the European Network for Rare Neurological Diseases. Prof. Bachoud-Lévi has extensive experience in clinical trials: for example, she coordinated the French phase 3 clinical trial on HD gene inhibition (Roche, NCT03761849), led the international Multicentric intra-Cerebral Grafting trial in HD (NCT00190450) and is involved in the global HD platform "Enroll". Prof. Bachoud-Lévi also leads the "Interventional Neuropsychology" team (INSERM U955 E01) hosted both at the Mondor Institute of Biomedical Research (UPEC) and at the Department of Cognitive Studies of the Ecole normale supérieure.

Prof. Philippe Remy (MD, PhD) (h index = 48, May 2022) is a full professor of neurology at UPEC. He is the director of the Parkinson's disease expert centre at Henri Mondor Hospital, which is part of the NS-Park national network dedicated to therapeutic research projects at the French national level. Prof. Rémy has a strong expertise in clinical trials and functional imaging.

Dr. Laurent Cleret de Langavant (MD, PhD) (h index = 15, May 2022) is a lecturer at UPEC and a neurologist at Henri Mondor Hospital. He is currently developing models with machine learning techniques to predict the onset of dementia, in collaboration with the University of California, San Francisco.

Dr. Charlotte Jacquemot (PhD) (h index = 11, May 2022) heads the Department of Cognitive Studies at the Ecole Normale Supérieure. She is an expert in language care in healthy individuals but also in patients with neurodegenerative diseases. She is developing language assessment tasks for the follow-up of patients and is working on the interaction between language and other cognitive functions, allowing the use of language as a polymarker.

Dr. Renaud Massart (PhD, MBA) (h index = 21, May 2022) has extensive experience in basic and translational research. He supervises scientific projects (set-up, fundraising, planning, follow-up, negotiation of public-private partnerships) for the evaluation and implementation of new therapeutic strategies.
(h index = 21, Mai 2022) a une grande expérience de la recherche fondamentale et translationnelle. Il supervise des projets scientifiques (montage, recherche de fonds, planification, suivi, négociation de partenariats public-privé) pour l'évaluation et la mise en œuvre de nouvelles stratégies thérapeutiques.