The propagation of tau assemblies in the brain contributes to the progression of Alzheimer’s disease. Researchers from NeurATRIS, at the Neurodegenerative Diseases Laboratory: mechanisms, therapies, imaging (CNRS/CEA/Université Paris-Sud, MIRCen), working in collaboration with the Ecole Normale Supérieure, Sorbonne University and Inserm, have just identified the targets of these assemblies. Published in the EMBO Journal on January 10, 2019, this work will enable the development of tools capable of blocking these key elements of aggregate propagation and thus combating their pathological effect.