Professor Klaus-Armin Nave from Max Planck Institute (Göttingen, Germany), will be at the Paris Brain Institute on January 8th, 2026 to give a lecture to the Master 2 BIP students of Sorbonne University.

Organized with the support of NeurATRIS to promote the training of young scientists, this event will be followed by a discussion and a lunch with the participants.

The event is open to all NeurATRIS members.

For more information, please contact Lamia BOUSLAMA (This email address is being protected from spambots. You need JavaScript enabled to view it.) or Carole ESCARTIN (This email address is being protected from spambots. You need JavaScript enabled to view it.).

Join us on September 29 for the NeurATRIS General Assembly!

Location: Collège franco-britannique de la Cité Internationale Universitaire de Paris, 75014.

On this occasion, come and discover the latest technological and methodological innovations developed within NeurATRIS, the major translational advances of the infrastructure, as well as new developments across the network’s platforms.

A key moment to foster exchanges between researchers, clinicians, technical staff, students, and industry partners involved in the field of translational neuroscience.

More information and the detailed program.

The event is open to all.
Free registration, but mandatory, until September 22, 2025.

The France Parkinson Association is launching its 2025 Calls for Projects in Medical, Clinical, and Fundamental Sciences.

These calls for projects are open from January 6, 2025, to March 9, 2025, and include:

• Grants for young researchers (three-year doctoral grants, funding for a fourth year of a Ph.D., or a first year of postdoctoral research), enabling them to complete or further develop their training in a research program focused on Parkinson's disease.

• Major Calls for Proposals, which allow teams to undertake large collaborative clinical and/or translational projects involving multiple sites and/or countries and/or disciplines.

• Support for research teams to help realize innovative and high-quality projects on Parkinson's disease. The aim is to foster a better understanding of the disease, stimulate the development of new diagnostic and therapeutic alternatives, and explore new avenues for the development of a curative treatment or improvements in patients' quality of life.

For more information:https://www.franceparkinson.fr/appel-a-projets/appel-a-projets-pour-faire-avancer-la-recherche/

NeurATRIS extends its best wishes to all members of its community.

2024 was marked by fruitful collaborations and exciting discoveries, and we are proud to have contributed with you, to the advancement of translational research in neuroscience. Many thanks to all of you!

Together, let’s make 2025 a year of success and new scientific progress!

Professor Christian Klämbt from the University of Münster, Germany, will be at the Paris Brain Institute on 2025, January 9th to give a lecture to the Master 2 BIP students of Sorbonne University.

Organized with the support of NeurATRIS to promote the training of young scientists, this event will be followed by a discussion and a lunch with the participants.

The event is open to all NeurATRIS members.

For more information, please contact Lamia BOUSLAMA (This email address is being protected from spambots. You need JavaScript enabled to view it.) or Carole ESCARTIN (This email address is being protected from spambots. You need JavaScript enabled to view it.).

As part of the Health Innovation Plan France 2030 call for projects, NeurATRIS has been selected to receive funding of €4.8 million, with the aim of modernizing its technological offering and accelerating its technological developments in terms of preclinical imaging and biomarker and biotherapy screening.

A STRATEGIC SUPPORT FOR FRENCH RESEARCH

As part of the France 2030 Health Innovation Plan, the government has decided to renew a large-scale investment plan for the biology-health sector, aimed at funding the rejuvenation and modernization of the technological and service offerings of the National Infrastructures for Biology and Health (INBS). This initiative seeks to maintain their competitiveness and better align their services with the needs of the relevant scientific communities.

A budget of 80 million euros has been allocated to the INBS to ensure their sustainability. NeurATRIS is among the seventeen infrastructures selected, underscoring the vital role of the infrastructure in the French landscape of translational neurosciences.

MODERNIZATION OF NEURATRIS EQUIPMENT

NeurATRIS offers a wide range of tools covering the entire continuum of translational neuroscience research, from molecular and cellular biology to studies on animal models and humans. However, with recent technological advancements, some essential equipment has become obsolete and needs to be renewed.

     * PRECLINICAL IN VIVO IMAGING:

     - The preclinical tomography scanners at the CEA-MIRCen PET platform, used for imaging biomarker studies, will be replaced by next-generation models that are more sensitive and offer higher resolution. This upgrade will facilitate advanced studies on rodent and non-human primate models.

     * IN VITRO SCREENING OF BIOTHERAPIES:

- The imaging platform at the Brain Institute (ICM.Quant) will be equipped with a high-throughput imaging system to study complex models, such as organotypic slices or organoids derived from human iPS cells.

- The animal histology platform at UMR 703 PAnTher (APEX) will acquire a multiphoton microscope for multi-scale phenotyping of tissues and cells.

- The imaging platform at Neuro-Bicêtre will replace its aging transmission electron microscope (TEM) and pair it with new correlative microscopy approaches (CLEM).

DEVELOPMENT OF NEW SCREENING AND ANALYSIS CAPABILITIES

In order to maintain NeurATRIS platforms at the highest scientific and technical level, new capabilities will also be developed.

     * IN VITRO SCREENING OF SMALL MOLECULES:

 - Leveraging the expertise of the histology (Histomics), genomics (iGenseq), and data analysis (DAC) platforms, the ICM will develop a new large-scale multi-Omics spatial histology platform to support the discovery of new therapeutic targets and biomarkers.

- The APEX platform at UMR 703 PAnTher will acquire a spinning-disk microscope coupled with a DeepSIM super-resolution module, enabling the acquisition of super-resolved data from thick, non-cleared samples.

     * IN VITRO SCREENING OF BIOTHERAPIES:

     - The bioinformatics platform at Henri Mondor Hospital will acquire new bioinformatics servers, essential for "machine learning" studies developed for the early diagnosis of patients with Huntington's disease or Parkinson's disease (voice analysis).

     - The proteomics platform at Henri Mondor Hospital will acquire protein quantification equipment for high-throughput analysis of biological samples from patients.

     - The DHIM platform of the NeuroDiderot Unit 1141 will acquire an ultra-resolution multiplexed imaging system, enabling complex analyses that require the detection of multiple biomarkers in biological samples.

It is worth noting that NeuraTRIS has also received a grant included in the State budget, ensuring the necessary funding for its operation in the coming years.

France Parkinson is funding 4 to 6 travel grants for the 5th Gordon Research Conference on Parkinson's Disease, which takes place from 8 to 13 June 2025 in Waterville Valley, New Hampshire, USA. The travel grants are intended for PhD or post-doctoc researchers, working on Parkinson's disease in a laboratory in France.

The Gordon Research Conference (GRC) on Parkinson's disease brings together scientists from many disciplines to discuss the most important questions in the basic science of Parkinson's disease, including the mechanisms of pathogenesis and pathophysiology, and how this might influence therapeutics.

As with the other GRCs, there will be plenty of time for discussion and informal networking opportunities between students, postdocs and group leaders. It is therefore a unique opportunity for young doctoral and post-doctoral researchers to present their work, discuss new methods, innovative ideas and pre-published data, and develop collaborative relationships with their peers. Experienced mentors and moderators will facilitate active participation in scientific discussions to enable all participants to be engaged actors rather than spectators.

The selection committee will choose a total of 150 abstracts. France Parkinson will support the travel and registration to the congress of the first 5 candidates meeting the following criteria:

          1. Work in a research centre in France

          2. Be a PhD student or post-doctoral fellow

          3. Have your abstract selected by the GRC committee.

If you are interested in taking part, please consult our current programme and send your application to https://www.grc.org/parkinson-s-disease-conference/2025/.

Oral presentations (particularly from junior researchers) will be selected from the abstracts submitted.

In order to promote the careers of doctoral and post-doctoral students, this meeting is associated with a Gordon Research Seminar (GRS), to be held on 7 and 8 June 2025. The GRS allows trainees to meet and learn more about the field before the GRC begins. View the agenda and register for the GRS here:https://www.grc.org/parkinson-s-disease-grs-conference/2025/ .

Other speakers (students and postdocs) will be selected from the abstracts submitted.

REGISTER NOW PLACES ARE LIMITED!

Join us on October 14, 2024, for the NeurATRIS' Annual General Assembly !

Location : Maison des Polytechniciens, Paris

This year, we offer an overview of the latest advances in translational neuroscience, focusing on neurodevelopmental diseases, multiple sclerosis and Alzheimer’s Parkinson’s and Huntington’s diseases.

Highlights of the day:
      - Review of last year’s achievements
      - Presentation of future perspectives for the infrastructure
      - Presentation of initiatives to promote translational neuroscience research as well as the training of young scientists.

More information and the detailed program.
 

Registration is free but mandatory, and opens on Monday, August 26, 2024.

The NeurATRIS Translational Neuroscience Days (TND2024) were held on May 24 and 25, 2024 at the Domaine Ker Juliette in Pornichet, France, as an annual meeting of the neuroscience ecosystem for academic and private players. Co-organized this year with INBS France-BioImaging (FBI) and France Life Imaging (FLI), this 5th edition focused on multi-scale imaging for translational neuroscience research.

DAY 1 :

Day 1 began with a plenary session on “Imaging as a tool for studying molecular and cellular processes”. Participants then attended a round-table discussion on “Data sharing and tools in neuroimaging: where do we stand and where are we going?” moderated and introduced by Michel Dojat (GIN, Inserm U1216 Statify et Inria). 

In the early afternoon, 11 students competed for the NeurATRIS “Next Generation Challenge” prize, presenting their research results in the form of posters. The NeurATRIS prize for the best scientific poster was awarded to not one, but two students who tied, namely Tiffany Bourgeton (UMR703 PAnTher, INRAE/ Oniris) and Victor Valcarcel (CNRS UMR 7221, MNHN).  The second plenary session dealt with “Imaging as a tool for analyzing cerebral and metabolic activity”. On this occasion, Fawzi Boumezbeur from CEA-NeuroSpin spoke about recent brain images obtained with the 11.7T Iseult MRI, a world first. 

This first day ended in a convivial atmosphere with a social event hosted by the improv troupe La LINA.

DAY 2:

The second and final day of the Journées des Neurosciences Translationnelles began with a special lecture by Professor Lehericy Stephane, Institut du Cerveau - Paris Brain Institute, Head of Neuroradiology at Hôpital Pitié-Salpêtrière on “Imaging in translational neuroscience around Parkinson's disease”.  This was followed by a third and final plenary session on “Imaging as a screening tool”.

Many thanks to all participants and speakers, not forgetting our partners and sponsors for supporting our event.

NeurATRIS is co-organizing with France Life Imaging (FLI) and France Bio-Imaging (FBI), the 5^th edition of its Translational Neuroscience Days (TND), on May 24 and 25, 2024 at Domaine Ker Juliette in Pornichet.

The event will take place over the full day of Friday May 24 and the morning of Saturday May 25, and will focus on multi-scale imaging for translational neuroscience research.

Objectives: (i) Present the latest scientific advances (plenary sessions); (ii) Debate a topical issue (round table); (iii) Promote the next generation by offering them the opportunity to present their work in the form of a poster ( Next Generation Challenge prize).

TND enables strong interactions between academic and private players in the field of neuroscience, with a strong focus on young researchers.

Language: French

The pre-programme and registration details will be available soon.

In 2023, NeurATRIS research generated 118 publications in peer-reviewed journals. Many thanks to all our teams and collaborators!

• Abjean, Laurene, Lucile Ben Haim, Miriam Riquelme-Perez, Pauline Gipchtein, Céline Derbois, Marie-Ange Palomares, Fanny Petit, et al. « Reactive Astrocytes Promote Proteostasis in Huntington’s Disease through the JAK2-STAT3 Pathway ». Brain: A Journal of Neurology 146, n^o 1 (5 janvier 2023): 149‑66. https://doi.org/10.1093/brain/awac068.
• Al-Obaidi, Hala, Zainab Khidhair, Feras Jirjees, Muna Barakat, Husam AlSalamat, Zelal Kharaba, Yassen Alfoteih, et al. « Factors Associated with Knowledge and Awareness of Stroke in the Iraqi Population: A Cross-Sectional Study ». Frontiers in Neurology 14 (2023): 1144481. https://doi.org/10.3389/fneur.2023.1144481.
• Andersen, Mads, Hannah Brogård Andersen, Ted Carl Kejlberg Andelius, Lærke Hjøllund Hansen, Regitze Pinnerup, Mette Bjerre, Steffen Ringgaard, et al. « No Neuroprotective Effect of Therapeutic Hypothermia Following Lipopolysaccharide-Sensitized Hypoxia-Ischemia: A Newborn Piglet Study ». Frontiers in Pediatrics 11 (2023): 1268237. https://doi.org/10.3389/fped.2023.1268237.
• Augustin, Sebastien, Marion Lam, Sophie Lavalette, Anna Verschueren, Frédéric Blond, Valérie Forster, Lauriane Przegralek, et al. « Melanophages Give Rise to Hyperreflective Foci in AMD, a Disease-Progression Marker ». Journal of Neuroinflammation 20, n^o 1 (8 février 2023): 28. https://doi.org/10.1186/s12974-023-02699-9.
• Berriat, Félix, Christian S. Lobsiger, et Séverine Boillée. « The Contribution of the Peripheral Immune System to Neurodegeneration ». Nature Neuroscience 26, n^o 6 (juin 2023): 942‑54. https://doi.org/10.1038/s41593-023-01323-6.
• Bertho, Annaig, Lorea Iturri, Elise Brisebard, Marjorie Juchaux, Cristèle Gilbert, Ramon Ortiz, Catherine Sebrie, et al. « Evaluation of the Role of the Immune System Response After Minibeam Radiation Therapy ». International Journal of Radiation Oncology, Biology, Physics 115, n^o 2 (1 février 2023): 426‑39. https://doi.org/10.1016/j.ijrobp.2022.08.011.
• Bizot, Flavien, Abdallah Fayssoil, Cécile Gastaldi, Tabitha Irawan, Xaysongkhame Phongsavanh, Arnaud Mansart, Thomas Tensorer, et al. « Oligonucleotide Enhancing Compound Increases Tricyclo-DNA Mediated Exon-Skipping Efficacy in the Mdx Mouse Model ». Cells 12, n^o 5 (23 février 2023): 702. https://doi.org/10.3390/cells12050702.
• Boccazzi, Marta, Giulia Macchiarulo, Sophie Lebon, Justyna Janowska, Tifenn Le Charpentier, Valérie Faivre, Jennifer Hua, et al. « G Protein-Coupled Receptor 17 Is Regulated by WNT Pathway during Oligodendrocyte Precursor Cell Differentiation ». Neurobiology of Disease 187 (15 octobre 2023): 106315. https://doi.org/10.1016/j.nbd.2023.106315.
• Bokobza, Cindy, Alice Jacquens, David Guenoun, Blandine Bianco, Anne Galland, Maxime Pispisa, Alexandra Cruz, et al. « Targeting the Brain 5-HT7 Receptor to Prevent Hypomyelination in a Rodent Model of Perinatal White Matter Injuries ». Journal of Neural Transmission (Vienna, Austria: 1996) 130, n^o 3 (mars 2023): 281‑97. https://doi.org/10.1007/s00702-022-02556-8.
• Boluda, Susana, Karima Mokhtari, Bruno Mégarbane, Djillali Annane, Bertrand Mathon, Albert Cao, Clovis Adam, et al. « Golgi Localization of SARS-CoV-2 Spike Protein and Interaction with Furin in Cerebral COVID-19 Microangiopathy: A Clue to the Central Nervous System Involvement? » Free Neuropathology 4 (janvier 2023): 4‑1. https://doi.org/10.17879/freeneuropathology-2023-4584.
• Bottani, Simona, Ninon Burgos, Aurélien Maire, Dario Saracino, Sebastian Ströer, Didier Dormont, Olivier Colliot, Alzheimer’s Disease Neuroimaging Initiative, et APPRIMAGE Study Group. « Evaluation of MRI-Based Machine Learning Approaches for Computer-Aided Diagnosis of Dementia in a Clinical Data Warehouse ». Medical Image Analysis 89 (octobre 2023): 102903. https://doi.org/10.1016/j.media.2023.102903.
• Bousset, Luc, Ania Alik, Ana Arteni, Anja Böckmann, Beat H. Meier, et Ronald Melki. « α-Synuclein Fibril, Ribbon and Fibril-91 Amyloid Polymorphs Generation for Structural Studies ». Methods in Molecular Biology (Clifton, N.J.) 2551 (2023): 345‑55. https://doi.org/10.1007/978-1-0716-2597-2_23.
• Boutros, Celina F., Walaa Khazaal, Maram Taliani, Najwane Said Sadier, Pascale Salameh, et Hassan Hosseini. « Factors Associated with Cognitive Impairment at 3, 6, and 12 Months after the First Stroke among Lebanese Survivors ». Brain and Behavior 13, n^o 1 (janvier 2023): e2837. https://doi.org/10.1002/brb3.2837.
• Butruille, L., P. Jubin, E. Martin, M. S. Aigrot, M. Lhomme, J. B. Fini, B. Demeneix, et al. « Deleterious Functional Consequences of Perfluoroalkyl Substances Accumulation into the Myelin Sheath ». Environment International 180 (octobre 2023): 108211. https://doi.org/10.1016/j.envint.2023.108211.
• Casse, Fanny, Thomas Courtin, Christelle Tesson, Mélanie Ferrien, Sandrine Noël, Anne-Laure Fauret-Amsellem, Thomas Gareau, et al. « Detection of ATXN2 Expansions in an Exome Dataset: An Underdiagnosed Cause of Parkinsonism ». Movement Disorders Clinical Practice 10, n^o 4 (avril 2023): 664‑69. https://doi.org/10.1002/mdc3.13699.
• Castanha, Nanci, Sylvain Challois, David Grenier, Patricia Le-Bail, Laurence Dubreil, et Tiphaine Lucas. « Multiphoton Microscopy Is a Nondestructive Label-Free Approach to Investigate the 3D Structure of Gas Cell Walls in Bread Dough ». Scientific Reports 13, n^o 1 (26 août 2023): 13971. https://doi.org/10.1038/s41598-023-39797-w.
• Célestine, Marina, Muriel Jacquier-Sarlin, Eve Borel, Fanny Petit, Jean-Baptiste Perot, Anne-Sophie Hérard, Luc Bousset, Alain Buisson, et Marc Dhenain. « Long Term Worsening of Amyloid Pathology, Cerebral Function, and Cognition after a Single Inoculation of Beta-Amyloid Seeds with Osaka Mutation ». Acta Neuropathologica Communications 11, n^o 1 (22 avril 2023): 66. https://doi.org/10.1186/s40478-023-01559-0.
• Ceyzériat, Kelly, Alekos Nicolaides, Quentin Amossé, Christine Fossey, Thomas Cailly, Frédéric Fabis, Valentina Garibotto, Carole Escartin, Benjamin B. Tournier, et Philippe Millet. « Reactive Astrocytes Mediate TSPO Overexpression in Response to Sustained CNTF Exposure in the Rat Striatum ». Molecular Brain 16, n^o 1 (5 juillet 2023): 57. https://doi.org/10.1186/s13041-023-01041-x.
• Chen, Charles D., Austin McCullough, Brian Gordon, Nelly Joseph-Mathurin, Shaney Flores, Nicole S. McKay, Diana A. Hobbs, et al. « Longitudinal Head-to-Head Comparison of 11C-PiB and 18F-Florbetapir PET in a Phase 2/3 Clinical Trial of Anti-Amyloid-β Monoclonal Antibodies in Dominantly Inherited Alzheimer’s Disease ». European Journal of Nuclear Medicine and Molecular Imaging 50, n^o 9 (juillet 2023): 2669‑82. https://doi.org/10.1007/s00259-023-06209-0.
• Chougar, Lydia, François-Xavier Lejeune, Johann Faouzi, Benjamin Morino, Alice Faucher, Nadine Hoyek, David Grabli, et al. « Comparison of Mean Diffusivity, R2* Relaxation Rate and Morphometric Biomarkers for the Clinical Differentiation of Parkinsonism ». Parkinsonism & Related Disorders 108 (mars 2023): 105287. https://doi.org/10.1016/j.parkreldis.2023.105287.
• Courte, Josquin, Ngoc Anh Le, Teng Pan, Luc Bousset, Ronald Melki, Catherine Villard, et Jean-Michel Peyrin. « Synapses Do Not Facilitate Prion-like Transfer of Alpha-Synuclein: A Quantitative Study in Reconstructed Unidirectional Neural Networks ». Cellular and Molecular Life Sciences: CMLS 80, n^o 10 (9 septembre 2023): 284. https://doi.org/10.1007/s00018-023-04915-4.
• Dahham, Jalal, Mickaël Hiligsmann, Ingrid Kremer, Samia J. Khoury, Hala Darwish, Hassan Hosseini, Silvia Evers, et Rana Rizk. « The Societal Costs of Multiple Sclerosis in Lebanon: A Cross-Sectional Study ». Expert Review of Pharmacoeconomics & Outcomes Research 23, n^o 4 (avril 2023): 419‑30. https://doi.org/10.1080/14737167.2023.2184802.
• Daly, Timothy, et Stéphane Epelbaum. « The Accelerated Approval of Aducanumab Invites a Rethink of the Current Model of Drug Development for Alzheimer’s Disease ». AJOB Neuroscience 14, n^o 3 (2023): 332‑35. https://doi.org/10.1080/21507740.2022.2048721.
• De Pace, Raffaella, Reza Maroofian, Adeline Paimboeuf, Mina Zamani, Maha S. Zaki, Saeid Sadeghian, Reza Azizimalamiri, et al. « Biallelic BORCS8 Variants Cause an Infantile-Onset Neurodegenerative Disorder with Altered Lysosome Dynamics ». Brain: A Journal of Neurology, 21 décembre 2023, awad427. https://doi.org/10.1093/brain/awad427.
• Delabar, Jean M., Julien Lagarde, Marta Fructuoso, Ammara Mohammad, Michel Bottlaender, Eric Doran, Ira Lott, et al. « Increased Plasma DYRK1A with Aging May Protect against Neurodegenerative Diseases ». Translational Psychiatry 13, n^o 1 (4 avril 2023): 111. https://doi.org/10.1038/s41398-023-02419-0.
• Denis, Hélèna L., Melanie Alpaugh, Claudia P. Alvarez, Alexis Fenyi, Roger A. Barker, Sylvain Chouinard, Cheryl H. Arrowsmith, et al. « Detection of Antibodies against the Huntingtin Protein in Human Plasma ». Cellular and Molecular Life Sciences: CMLS 80, n^o 2 (18 janvier 2023): 45. https://doi.org/10.1007/s00018-023-04687-x.
• Dodet, P. « REM Behavior Disorder: When Parkinson’s Disease Meets Morpheus ». Revue Neurologique 179, n^o 7 (octobre 2023): 667‑74. https://doi.org/10.1016/j.neurol.2023.08.005.
• Donato, Cristina, Daniella Balduino Victorino, Carolina Cabezas, Andrea Aguirre, Joana Lourenço, Marie-Claude Potier, Javier Zorrilla de San Martin, et Alberto Bacci. « Pharmacological Signature and Target Specificity of Inhibitory Circuits Formed by Martinotti Cells in the Mouse Barrel Cortex ». The Journal of Neuroscience: The Official Journal of the Society for Neuroscience 43, n^o 1 (4 janvier 2023): 14‑27. https://doi.org/10.1523/JNEUROSCI.1661-21.2022.
• Dubreil, Laurence, Noreddine Damane, Romain Fleurisson, Marine Charrier, Julien Pichon, Isabelle Leroux, Cindy Schleder, et al. « Specific and Label-Free Endogenous Signature of Dystrophic Muscle by Synchrotron Deep Ultraviolet Radiation ». Scientific Reports 13, n^o 1 (4 juillet 2023): 10808. https://doi.org/10.1038/s41598-023-37762-1.
• Düchs, Matthias, Dragica Blazevic, Philipp Rechtsteiner, Cynthia Kenny, Thorsten Lamla, Sarah Low, Jimmy Savistchenko, et al. « AAV-Mediated Expression of a New Conformational Anti-Aggregated α-Synuclein Antibody Prolongs Survival in a Genetic Model of α-Synucleinopathies ». NPJ Parkinson’s Disease 9, n^o 1 (15 juin 2023): 91. https://doi.org/10.1038/s41531-023-00542-9.
• Ducongé, Frédéric. « Improvement of Aptamers by High-Throughput Sequencing of Doped-SELEX ». Methods in Molecular Biology (Clifton, N.J.) 2570 (2023): 85‑102. https://doi.org/10.1007/978-1-0716-2695-5_7.
• Duwat, Charlotte, Pauline Léal, Audrey Vautheny, Gwennaëlle Aurégan, Charlène Joséphine, Marie-Claude Gaillard, Anne-Sophie Hérard, et al. « Development of an AAV-Based Model of Tauopathy Targeting Retinal Ganglion Cells and the Mouse Visual Pathway to Study the Role of Microglia in Tau Pathology ». Neurobiology of Disease 181 (1 juin 2023): 106116. https://doi.org/10.1016/j.nbd.2023.106116.
• Elena-Real, Carlos A., Annika Urbanek, Xamuel L. Lund, Anna Morató, Amin Sagar, Aurélie Fournet, Alejandro Estaña, et al. « Multi-Site-Specific Isotopic Labeling Accelerates High-Resolution Structural Investigations of Pathogenic Huntingtin Exon-1 ». Structure (London, England: 1993) 31, n^o 6 (1 juin 2023): 644-650.e5. https://doi.org/10.1016/j.str.2023.04.003.
• Epelbaum, Stéphane, et Federica Cacciamani. « Clinical Assessment of Brain Disorders ». In Machine Learning for Brain Disorders, édité par Olivier Colliot. New York, NY: Humana, 2023. http://www.ncbi.nlm.nih.gov/books/NBK597487/.
• Fang, Li, Alex Mas Monteys, Alexandra Dürr, Megan Keiser, Congsheng Cheng, Akhil Harapanahalli, Pedro Gonzalez-Alegre, Beverly L. Davidson, et Kai Wang. « Haplotyping SNPs for Allele-Specific Gene Editing of the Expanded Huntingtin Allele Using Long-Read Sequencing ». HGG Advances 4, n^o 1 (12 janvier 2023): 100146. https://doi.org/10.1016/j.xhgg.2022.100146.
• Faouzi, Johann, Olivier Colliot, et Jean-Christophe Corvol. « Machine Learning for Parkinson’s Disease and Related Disorders ». In Machine Learning for Brain Disorders, édité par Olivier Colliot. New York, NY: Humana, 2023. http://www.ncbi.nlm.nih.gov/books/NBK597492/.
• Fayard, Audrey, Alexis Fenyi, Sonia Lavisse, Sandra Dovero, Luc Bousset, Tracy Bellande, Sophie Lecourtois, et al. « Functional and Neuropathological Changes Induced by Injection of Distinct Alpha-Synuclein Strains: A Pilot Study in Non-Human Primates ». Neurobiology of Disease 180 (mai 2023): 106086. https://doi.org/10.1016/j.nbd.2023.106086.
• Fevga, Christina, Christelle Tesson, Ana Carreras Mascaro, Thomas Courtin, Riaan van Coller, Salma Sakka, Federico Ferraro, et al. « PTPA Variants and Impaired PP2A Activity in Early-Onset Parkinsonism with Intellectual Disability ». Brain: A Journal of Neurology 146, n^o 4 (19 avril 2023): 1496‑1510. https://doi.org/10.1093/brain/awac326.
• Frisoni, Giovanni B., Daniele Altomare, Federica Ribaldi, Nicolas Villain, Carol Brayne, Naaheed Mukadam, Marc Abramowicz, et al. « Dementia Prevention in Memory Clinics: Recommendations from the European Task Force for Brain Health Services ». The Lancet Regional Health. Europe 26 (mars 2023): 100576. https://doi.org/10.1016/j.lanepe.2022.100576.
• Fürtjes, Anna E., James H. Cole, Baptiste Couvy-Duchesne, et Stuart J. Ritchie. « A Quantified Comparison of Cortical Atlases on the Basis of Trait Morphometricity ». Cortex; a Journal Devoted to the Study of the Nervous System and Behavior 158 (janvier 2023): 110‑26. https://doi.org/10.1016/j.cortex.2022.11.001.
• Garin, Clément M., et Marc Dhenain. « Mean Amplitude of Low Frequency Fluctuations Measured by fMRI at 11.7 T in the Aging Brain of Mouse Lemur Primate ». Scientific Reports 13, n^o 1 (17 mai 2023): 7970. https://doi.org/10.1038/s41598-023-33482-8.
• Gavoille, Antoine, Fabien Rollot, Romain Casey, Marc Debouverie, Emmanuelle Le Page, Jonathan Ciron, Jerome De Seze, et al. « Investigating the Long-Term Effect of Pregnancy on the Course of Multiple Sclerosis Using Causal Inference ». Neurology 100, n^o 12 (21 mars 2023): e1296‑1308. https://doi.org/10.1212/WNL.0000000000206774.
• Genovese, Guglielmo, Belén Diaz-Fernandez, François-Xavier Lejeune, Itamar Ronen, Małgorzata Marjańska, Lydia Yahia-Cherif, Stéphane Lehéricy, Francesca Branzoli, et Charlotte Rosso. « Longitudinal Monitoring of Microstructural Alterations in Cerebral Ischemia with in Vivo Diffusion-Weighted MR Spectroscopy ». Radiology 306, n^o 3 (mars 2023): e220430. https://doi.org/10.1148/radiol.220430.
• Géraudie, Amandine, Maximilien Riche, Thaïs Lestra, Alexandre Trotier, Léo Dupuis, Bertrand Mathon, Alexandre Carpentier, et Benoît Delatour. « Effects of Low-Intensity Pulsed Ultrasound-Induced Blood-Brain Barrier Opening in P301S Mice Modeling Alzheimer’s Disease Tauopathies ». International Journal of Molecular Sciences 24, n^o 15 (3 août 2023): 12411. https://doi.org/10.3390/ijms241512411.
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• Walton, Sara, Alexis Fenyi, Tyler Tittle, Ellen Sidransky, Gian Pal, Solji Choi, Ronald Melki, Bryan A. Killinger, et Jeffrey H. Kordower. « Neither Alpha-Synuclein-Preformed Fibrils Derived from Patients with GBA1 Mutations nor the Host Murine Genotype Significantly Influence Seeding Efficacy in the Mouse Olfactory Bulb ». bioRxiv: The Preprint Server for Biology, 25 août 2023, 2023.08.24.554646. https://doi.org/10.1101/2023.08.24.554646.
• Xicota, Laura, Julien Lagarde, Fanny Eysert, Benjamin Grenier-Boley, Isabelle Rivals, Alexandra Botté, Sylvie Forlani, et al. « Modifications of the Endosomal Compartment in Fibroblasts from Sporadic Alzheimer’s Disease Patients Are Associated with Cognitive Impairment ». Translational Psychiatry 13, n^o 1 (14 février 2023): 54. https://doi.org/10.1038/s41398-023-02355-z.
• Yazdan-Panah, Arya, Marius Schmidt-Mengin, Vito A. G. Ricigliano, Théodore Soulier, Bruno Stankoff, et Olivier Colliot. « Automatic Segmentation of the Choroid Plexuses: Method and Validation in Controls and Patients with Multiple Sclerosis ». NeuroImage. Clinical 38 (2023): 103368. https://doi.org/10.1016/j.nicl.2023.103368.
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As part of NeurATRIS' support to students training, Anna Williams from the Institute for Regeneration and Repair at the University of Edinburgh will give a lecture on December 20, 2023 to the students of the Master 2 BIP. This lecture  will be followed by a discussion and lunch with students. All NeurATRIS members are welcome.

PASREL-Imagerie organizes the 2nd "Accelerating drug development using biomedical imaging" scientific day on February 9, 2024 at the Cité Internationale Universitaire in Paris.

Dedicated to all biomedical stakeholders, the event will highlight the translational role of MRI and Ultrasound in drug discovery.

The day will provide an opportunity to :

• Listen to innovative projects by industrial and academic partners
• Discover the latest advances with expert speakers on non-isotopic imaging to de-risk medical innovations
• Develop your network

  Online registration is free and compulsory before February 05, 2024 : https://accelerating-drug-development-2023.b2match.io/

Where?  Centre de congrès, Lyon

When? October 18 and 19, 2023

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Come and meet NeurATRIS on October 18 & 19, 2023, at the Rendez-Vous Carnot, the R&D meeting place for companies.

We'll be exhibiting in the research infrastructure village, stand U03.

Meet us to discuss your projects and find out more about NeurATRIS!

We look forward to hearing from you!
 

More info on the event.

The ICM's Histomics platform is organizing a workshop entirely dedicated to "Recent advances in spatial transcriptomics in the brain ". This event will take place at the ICM's Edmond and Lily Safra Auditorium, on November 03, 2023 from 9:00 am to 06:00 pm.

The objectives of this day are multiple: (i) to present spatial transcriptomics and review current knowledge and future challenges; (ii) to offer practical experience on how to analyze and interpret spatial transcriptomics data; (iii) to establish a network of experts and collaborators who can share their experience on spatial transcriptomics and its application in the brain (participants, speakers and industrial partners).

Registration is free but mandatory (limited number of places) before October 20, 2023, via this link or the QR code below.

The first "NeuroSpin Translational Meetings" will be held in Gif-sur-Yvette on 17 and 18 November 2023.

The aim of this conference is to bring together neuroimaging researchers and clinician scientists involved in clinical research, to discuss current issues relating to neurodevelopmental disorders.

Are you a clinician or a scientist? Are you involved in some way in clinical or basic neuroimaging research? Don't hesitate to register for these first NeuroSpin Translational Meetings!

More details and registration.

Join us on December 07, 2023 at the Centre International de Conférences Sorbonne Université in Paris for the NeurATRIS Annual General Meeting. 

This day will be an opportunity to take stock of the actions and results obtained to date, to exchange views on both the scientific activities of the NeurATRIS thematic work-packages and the collaborative projects carried out under the various calls for projects and to discuss the infrastructure's future.

More information on the programme and registration to follow here.

Mark your calendars!

In 2022, NeurATRIS celebrated 10 years of research into neurodegenerative and neurodevelopmental diseases.

The work carried out by our teams in the 4 main areas of neuroscience and neurology research - (1) Cell therapy, (2) Gene therapy, (3) Drug therapies and (4) In vivo evaluation and therapeutic efficacy - has resulted in the publication of more than 1,200 publications over the period 2012-2022, with a steadily increasing annual figure since 2018.

2022: NEURATRIS PUBLICATIONS 2022

2021: NEURATRIS PUBLICATIONS 2021

2020: NEURATRIS PUBLICATIONS 2020

2019: NEURATRIS PUBLICATIONS 2019

2018: NEURATRIS PUBLICATIONS 2018

2017: NEURATRIS PUBLICATIONS 2017

Don't miss the opportunity to learn more about NeurATRIS at the NECTAR 2023 conference in Naples, Italy. Our Partnership Manager will be present throughout the conference.

Conference registration. 

Congratulations to Tom Lakomy, PhD student at MIRCen (CEA), who has won the NeurATRIS prize for the best scientific image of 2022-2023. This prize is awarded as part of the MIRCenImage contest: "Ta science en image", organized by the MIRCen department at CEA Fontenay-aux-Roses.

"GFAP immunostaining of tanycytes near the third ventricule with co-staining of STAT3+ cells in a mouse brain"

NeurATRIS co-organizes with the Microglia and Neuroinflammation GDR, the "Microglia from genes to functions" workshop, which will take place from November 27 to December 01, 2023, at the Bordeaux School of Neuroscience.

The aim of this first edition is to provide a comprehensive 5-day training course on current topics in microglia research. The program covers three aspects: (1) understanding and analyzing omics data (2) characterizing microglial metabolism (3) analyzing microglia morphology and dynamics using ex vivo and in vivo 2-photon microscopy approaches.

More information.

NeurATRIS supports the Workshop on Diffusion MRI, which will take place from September 5 to 8, 2023, in Cardiff.

The aim is to introduce scientists and clinicians working in the field of medical imaging to diffusion-weighted magnetic resonance imaging and train them to undertake the first basic steps towards using this technique in clinical and preclinical settings.

As part of its support for the training of young researchers, NeurATRIS is offering 5 stipends.

Application deadline: October 31, 2023.

More details and registration.

Registration for the 5-day course on “Translational Medicine Explained (TMex) ” in November 2023 in Berlin is now open !

The TMex Winter School is targeted to PhD/MD students in the second half of their PhD, postdocs and other young scientists who are involved in biomedical research. 

The course covers a variety of activities, including a drug discovery game, elevator pitches, group work and lectures. Experts from academia and industry will be addressing essential elements of the translational pipeline such as target product profiles, research and development of biologics, clinical trials, regulatory support, science communication, patient-driven research and personalised medicine. Several innovation sessions will take place, covering novel drug delivery methods and academia-biotech-industry collaboration. 

Dates: 13- 17 November 2023, 9:00 - 18:00 CET

Location : Bayer Pharmaceuticals Headquarters, Berlin, Germany

More info and registration

We'll be exibiting at AFSSI Connexions in Montpellier on 4 and 5 July ! ☀️

Meet us on our stand in the heart of the exhibition area to discuss your projects?

We're proud to be taking part in this highlight of @AFSSI Life Sciences!

These two days will be devoted to exchanges between French #services and #innovation companies and key players in the ecosystem?

Register to meet our team: https://bit.ly/InscriptionAC23