Team 4, GenMedStroke: Genomics and personalised medicine in cerebrovascular disease
. Cerebrovascular disease is an important public health issue, its major complication being stroke. Known underlying causes include atherosclerosis, cardioembolic disease, vascular malformations, ischaemic or haemorrhagic small vessel disease and inherited vasculopathies. However, the underlying causes remain undetermined in many patients, including fetuses, children and adults, preventing the development of therapeutic options.
The main objectives of the GeneMedStroke team are i) to improve the etiological diagnosis of cerebrovascular diseases through the identification of their genetic determinants, ii) to better understand their mechanisms, by combining patient/in vivo model studies, iii) to apply these data to the development of diagnostic tests and new preventive and curative therapeutic approaches.