Neuroimaging webinars powered by EATRIS and NeurATRIS

We are pleased to announce that EATRIS and NEURATRIS are launching a series of webinars on Neuroimaging in November of this year. The series will cover the usage of CEST-MRI, optical  imaging and PET imaging in neurodegenerative diseases and their potential application in translational medicine. These webinars will be brought to you by experts in the field.

All webinars will take place from 14:00-15:00 CET and are free of charge. The neuroimaging webinars include an audience Q&A session during which attendees can ask questions at the end of the lecture. Please note that all webinars will be recorded and available for later viewing.

International multi-site collaboration hub will implement new clinical imaging tools and deliver several projects per year with enhanced speed and throughput

Amsterdam, The Netherlands, June 4, 2018 -  The European Infrastructure for Translational Medicine (EATRIS) has formed a collaboration with GlaxoSmithKline (GSK) to deliver a clinical and scientific expert network for the development and application of innovative imaging methods for inflammatory diseases.

The iPEPS innovation accelerator and Scientist.com are launching a call for biotech startups developing a novel therapeutic and/or diagnostic approach with a main focus on central nervous system (CNS) diseases (neuro-oncology, psychiatry, neurological disorders or preventive health).

Apply now until July 16th, and get awarded:

  • Up to 6 months office/lab spaces at iPEPS
  • Up to $10,000 in research services through Scientist.com marketplace (to be used within one year)
  • Consulting with experts in preclinical/clinical development to build out your TPP (target product profile).

The winner of this competition and the runner-up will be announced at the end of September and will benefit of iPEPS mentoring to fast track the development of their projects in one of the most thriving research and innovation ecosystem in Paris.

bandeau AAP iPEPS 2018

​Les larges agrégats de protéines Tau observés dans les neurones des personnes atteintes de la maladie d’Alzheimer sont considérés comme étant au moins partiellement à l’origine de la maladie. Une étude conduite par des chercheurs de MIRCen (Institut de biologie François Jacob/CEA, NeurATRIS) suggère au contraire que ces dégénérescences neurofibrillaires (DNF) joueraient un rôle protecteur. 

Accumulation of amyloid-β (Aβ) peptides in the brain is a critical early event in the pathogenesis of Alzheimer's disease (AD), the most common age-related neurodegenerative disorder. There is increasing interest in measuring levels of plasma Aβ since this could help in diagnosis of brain pathology. However, the value of plasma Aβ in such a diagnosis is still controversial and factors modulating its levels are still poorly understood.

In 2017, NeurATRIS teams published 97 articles in peer-reviewed scientific journals.

 

  • Alves, Sandro, Guillaume Churlaud, Mickael Audrain, Kristin Michaelsen-Preusse, Romain Fol, Benoit Souchet, Jerome Braudeau, Martin Korte, David Klatzmann, et Nathalie Cartier. « Interleukin-2 Improves Amyloid Pathology, Synaptic Failure and Memory in Alzheimer’s Disease Mice ». Brain 140 (mars 2017): 826‑42. https://doi.org/10.1093/brain/aww330.
  • Alves, Sandro, Guillaume Churlaud, David Klatzmann, et Nathalie Cartier. « Reply: Beneficial Effect of Interleukin-2-Based Immunomodulation in Alzheimer-like Pathology ». Brain 140 (juillet 2017): e40. https://doi.org/10.1093/brain/awx109.
  • Aoun Sebaiti, Mehdi, Paul Kauv, Anaïs Charles-Nelson, Axel Van Der Gucht, Paul Blanc-Durand, Emmanuel Itti, Romain K. Gherardi, Anne-Catherine Bachoud-Levi, et François Jérôme Authier. « Cognitive Dysfunction Associated with Aluminum Hydroxide-Induced Macrophagic Myofasciitis: A Reappraisal of Neuropsychological Profile ». Journal of Inorganic Biochemistry, 6 octobre 2017. https://doi.org/10.1016/j.jinorgbio.2017.09.019.
  • Araujo, Ericky C. A., N. Azzabou, A. Vignaud, G. Guillot, et P. G. Carlier. « Quantitative Ultrashort TE Imaging of the Short-T-2 Components in Skeletal Muscle Using an Extended Echo-Subtraction Method ». Magnetic Resonance in Medicine 78, no 3 (septembre 2017): 997‑1008. https://doi.org/10.1002/mrm.26489.
  • Ardura-Fabregat, A., E. W. G. M. Boddeke, A. Boza-Serrano, S. Brioschi, S. Castro-Gomez, K. Ceyzeriat, C. Dansokho, et al. « Targeting Neuroinflammation to Treat Alzheimer’s Disease ». Cns Drugs 31, no 12 (décembre 2017): 1057‑82. https://doi.org/10.1007/s40263-017-0483-3.
  • Balbastre, Yael, Denis Riviere, Nicolas Souedet, Clara Fischer, Anne-Sophie Herard, Susannah Williams, Michel E. Vandenberghe, et al. « Primatologist: A Modular Segmentation Pipeline for Macaque Brain Morphometry ». Neuroimage 162 (15 novembre 2017): 306‑21. https://doi.org/10.1016/j.neuroimage.2017.09.007.
  • Belzeaux, Raoul, Marie-Noelle Lefebvre, Anne Lazzari, Tifenn Le Carpentier, Julia-Lou Consoloni, Xavier Zendjidjian, Mocrane Abbar, et al. « How to: Measuring Blood Cytokines in Biological Psychiatry Using Commercially Available Multiplex Immunoassays ». Psychoneuroendocrinology 75 (janvier 2017): 72‑82. https://doi.org/10.1016/j.psyneuen.2016.10.010.
  • Ben M’Barek, Karim, Walter Habeler, Alexandra Plancheron, Mohamed Jarraya, Florian Regent, Angelique Terray, Ying Yang, et al. « Human ESC-Derived Retinal Epithelial Cell Sheets Potentiate Rescue of Photoreceptor Cell Loss in Rats with Retinal Degeneration ». Science Translational Medicine 9, no 421 (20 décembre 2017): eaai7471. https://doi.org/10.1126/scitranslmed.aai7471.
  • Bey, K., C. Ciron, L. Dubreil, J. Deniaud, M. Ledevin, J. Cristini, V. Blouin, P. Aubourg, et M.-A. Colle. « Efficient CNS Targeting in Adult Mice by Intrathecal Infusion of Single-Stranded AAV9-GFP for Gene Therapy of Neurological Disorders ». Gene Therapy 24, no 5 (mai 2017): 325‑32. https://doi.org/10.1038/gt.2017.18.
  • Bielle, Franck, Francois Ducray, Karima Mokhtari, Caroline Dehais, Homa Adle-Biassette, Catherine Carpentier, Anais Chanut, et al. « Tumor Cells with Neuronal Intermediate Progenitor Features Define a Subgroup of 1p/19q Co-Deleted Anaplastic Gliomas ». Brain Pathology 27, no 5 (septembre 2017): 567‑79. https://doi.org/10.1111/bpa.12434.
  • Bitoun, Samuel, Pierre Roques, Thibaut Larcher, Gaetane Nocturne, Che Serguera, Pascale Chretien, Guy Serre, Roger Le Grand, et Xavier Mariette. « Both Systemic and Intra-Articular Immunization with Citrullinated Peptides Are Needed to Induce Arthritis in the Macaque ». Frontiers in Immunology 8 (20 décembre 2017): 1816. https://doi.org/10.3389/fimmu.2017.01816.
  • Blaise, Benjamin J., Leslie Schwendimann, Vibol Chhor, Vincent Degos, Mark P. Hodson, Guido Dallmann, Matthias Keller, Pierre Gressens, et Bobbi Fleiss. « Persistently Altered Metabolic Phenotype Following Perinatal Excitotoxic Brain Injury ». Developmental Neuroscience 39, no 1‑4 (2017): 182‑91. https://doi.org/10.1159/000464131.
  • Bonvento, Gilles, Julien Valette, Julien Flament, Fanny Mochel, et Emmanuel Brouillet. « Imaging and Spectroscopic Approaches to Probe Brain Energy Metabolism Dysregulation in Neurodegenerative Diseases ». Journal of Cerebral Blood Flow and Metabolism 37, no 6 (juin 2017): 1927‑43. https://doi.org/10.1177/0271678X17697989.
  • Branchu, Julien, Maxime Boutry, Laura Sourd, Marine Depp, Celine Leone, Alexandrine Corriger, Maeva Vallucci, et al. « Loss of Spatacsin Function Alters Lysosomal Lipid Clearance Leading to Upper and Lower Motor Neuron Degeneration ». Neurobiology of Disease 102 (juin 2017): 21‑37. https://doi.org/10.1016/j.nbd.2017.02.007.
  • Broad, Kevin D., Go Kawano, Igor Fierens, Eridan Rocha-Ferreira, Mariya Hristova, Mojgan Ezzati, Jamshid Rostami, et al. « Surgery Increases Cell Death and Induces Changes in Gene Expression Compared with Anesthesia Alone in the Developing Piglet Brain ». Plos One 12, no 3 (29 mars 2017): e0173413. https://doi.org/10.1371/journal.pone.0173413.
  • Cambon, Karine, Virginie Zimmer, Sylvain Martineau, Marie-Claude Gaillard, Margot Jarrige, Aurore Bugi, Jana Miniarikova, et al. « Preclinical Evaluation of a Lentiviral Vector for Huntingtin Silencing ». Molecular Therapy-Methods & Clinical Development 5 (juin 2017): 259‑76. https://doi.org/10.1016/j.omtm.2017.05.001.
  • Cavicchioli, L., S. Ferraresso, S. Westmoreland, S. Kaliyaperumal, H. Knight, C. Crossan, L. Scobie, et al. « Posttransplant Lymphoproliferative Disorders in Neuronal Xenotransplanted Macaques ». Veterinary Pathology 54, no 2 (mars 2017): 336‑44. https://doi.org/10.1177/0300985816669407.
  • Chaffiol, Antoine, Romain Caplette, Celine Jaillard, Elena Brazhnikova, Melissa Desrosiers, Elisabeth Dubus, Laetitia Duhamel, et al. « A New Promoter Allows Optogenetic Vision Restoration with Enhanced Sensitivity in Macaque Retina ». Molecular Therapy 25, no 11 (1 novembre 2017): 2546‑60. https://doi.org/10.1016/j.ymthe.2017.07.011.
  • Chaudhry, Nagarathnamma, Corinne Bachelin, Violetta Zujovic, Melissa Hilaire, Katherine T. Baldwin, Rose M. Follis, Roman Giger, Bruce D. Carter, Anne Baron-Van Evercooren, et Marie T. Filbin. « Myelin-Associated Glycoprotein Inhibits Schwann Cell Migration and Induces Their Death ». Journal of Neuroscience 37, no 24 (14 juin 2017): 5885‑99. https://doi.org/10.1523/JNEUROSCI.1822-16.2017.
  • Chhor, Vibol, Raffaella Moretti, Tifenn Le Charpentier, Stephanie Sigaut, Sophie Lebon, Leslie Schwendimann, Marie-Virginie Ore, et al. « Role of Microglia in a Mouse Model of Paediatric Traumatic Brain Injury ». Brain Behavior and Immunity 63 (juillet 2017): 197‑209. https://doi.org/10.1016/j.bbi.2016.11.001.
  • Cipriani, Sara, Nathalie Journiac, Jeannette Nardelli, Catherine Verney, Anne-Lise Delezoide, Fabien Guimiot, Pierre Gressens, et Homa Adle-Biassette. « Dynamic Expression Patterns of Progenitor and Neuron Layer Markers in the Developing Human Dentate Gyrus and Fimbria ». Cerebral Cortex 27, no 1 (janvier 2017): 358‑72. https://doi.org/10.1093/cercor/bhv223.
  • Comoy, Emmanuel E., Jacqueline Mikol, Nina Jaffré, Vincent Lebon, Etienne Levavasseur, Nathalie Streichenberger, Chryslain Sumian, et al. « Experimental Transfusion of Variant CJD-Infected Blood Reveals Previously Uncharacterised Prion Disorder in Mice and Macaque ». Nature Communications 8, no 1 (2 novembre 2017): 1268. https://doi.org/10.1038/s41467-017-01347-0.
  • Djelti, Fathia, Marc Dhenain, Jeremy Terrien, Jean-Luc Picq, Isabelle Hardy, Delphine Champeval, Martine Perret, Esther Schenker, Jacques Epelbaum, et Fabienne Aujard. « Impaired Fasting Blood Glucose Is Associated to Cognitive Impairment and Cerebral Atrophy in Middle-Aged Non-Human Primates ». Aging-Us 9, no 1 (janvier 2017): 3‑16. https://doi.org/10.18632/aging.101148.
  • Domingues, Sophie, Yolande Masson, Aurore Marteyn, Jennifer Allouche, Anselme L. Perrier, Marc Peschanski, Cecile Martinat, Christine Baldeschi, et Gilles Lemaitre. « Differentiation of Nonhuman Primate Pluripotent Stem Cells into Functional Keratinocytes ». Stem Cell Research & Therapy 8 (19 décembre 2017): 285. https://doi.org/10.1186/s13287-017-0741-9.
  • Dubreil, Laurence, Isabelle Leroux, Mireille Ledevin, Cindy Schleder, Lydie Lagalice, Claire Lovo, Romain Fleurisson, et al. « Multi-Harmonic Imaging in the Second Near-Infrared Window of Nanoparticle-Labeled Stem Cells as a Monitoring Tool in Tissue Depth ». Acs Nano 11, no 7 (juillet 2017): 6672‑81. https://doi.org/10.1021/acsnano.7b00773.
  • Dudeffant, Clemence, Matthias Vandesquille, Kelly Herbert, Clement M. Garin, Sandro Alves, Veronique Blanchard, Emmanuel E. Comoy, Fanny Petit, et Marc Dhenain. « Contrast-Enhanced MR Microscopy of Amyloid Plaques in Five Mouse Models of Amyloidosis and in Human Alzheimer’s Disease Brains ». Scientific Reports 7 (10 juillet 2017): 4955. https://doi.org/10.1038/s41598-017-05285-1.
  • Duhamel, Paul, Marwa Ounissi, Thomas Le Saux, Hugues Bienayme, Catherine Chiron, et Vincent Jullien. « Determination of the R(-) and S(+)-Enantiomers of Vigabatrin in Human Plasma by Ultra-High-Performance Liquid Chromatography and Tandem Mass-Spectrometry ». Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 1070 (1 décembre 2017): 31‑36. https://doi.org/10.1016/j.jchromb.2017.10.037.
  • Dyck, Peter J., John C. Kincaid, P. James B. Dyck, Vinay Chaudhry, Namita A. Goyal, Christina Alves, Hayet Salhi, et al. « Assessing Mnis+7(Ionis) and International Neurologists’ Proficiency in a Familial Amyloidotic Polyneuropathy Trial ». Muscle & Nerve 56, no 5 (novembre 2017): 901‑11. https://doi.org/10.1002/mus.25563.
  • Easton, J. Donald, Maria Aunes, Gregory W. Albers, Pierre Amarenco, Sara Bokelund-Singh, Hans Denison, Scott R. Evans, et al. « Risk for Major Bleeding in Patients Receiving Ticagrelor Compared With Aspirin After Transient Ischemic Attack or Acute Ischemic Stroke in the SOCRATES Study (Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes) ». Circulation 136, no 10 (5 septembre 2017): 907-+. https://doi.org/10.1161/CIRCULATIONAHA.117.028566.
  • Ehrlich, Marc, Sabah Mozafari, Michael Glatza, Laura Starost, Sergiy Velychko, Anna-Lena Hallmann, Qiao-Ling Cui, et al. « Rapid and Efficient Generation of Oligodendrocytes from Human Induced Pluripotent Stem Cells Using Transcription Factors ». Proceedings of the National Academy of Sciences of the United States of America 114, no 11 (14 mars 2017): E2243‑52. https://doi.org/10.1073/pnas.1614412114.
  • Eichler, Florian, Christine Duncan, Patricia L. Musolino, Paul J. Orchard, Satiro De Oliveira, Adrian J. Thrasher, Myriam Armant, et al. « Hematopoietic Stem-Cell Gene Therapy for Cerebral Adrenoleukodystrophy ». New England Journal of Medicine 377, no 17 (26 octobre 2017): 1630‑38. https://doi.org/10.1056/NEJMoa1700554.
  • El Behi, Mohamed, Charles Sanson, Corinne Bachelin, Léna Guillot-Noël, Jennifer Fransson, Bruno Stankoff, Elisabeth Maillart, et al. « Adaptive Human Immunity Drives Remyelination in a Mouse Model of Demyelination ». Brain: A Journal of Neurology 140, no 4 (1 avril 2017): 967‑80. https://doi.org/10.1093/brain/awx008.
  • Enuka, Yehoshua, Morris E. Feldman, Animesh Chowdhury, Swati Srivastava, Moshit Lindzen, Aldema Sas-Chen, Renaud Massart, et al. « Epigenetic Mechanisms Underlie the Crosstalk between Growth Factors and a Steroid Hormone ». Nucleic Acids Research 45, no 22 (15 décembre 2017). https://doi.org/10.1093/nar/gkx865.
  • Ezzati, Mojgan, Go Kawano, Eridan Rocha-Ferreira, Daniel Alonso-Alconada, Jane K. Hassell, Kevin D. Broad, Igor Fierens, et al. « Dexmedetomidine Combined with Therapeutic Hypothermia Is Associated with Cardiovascular Instability and Neurotoxicity in a Piglet Model of Perinatal Asphyxia ». Developmental Neuroscience 39, no 1‑4 (2017): 156‑70. https://doi.org/10.1159/000458438.
  • Forier, Cynthia, Egisto Boschetti, Mohamed Ouhammouch, Agnes Cibiel, Frederic Duconge, Michel Nogre, Michel Tellier, et al. « DNA Aptamer Affinity Ligands for Highly Selective Purification of Human Plasma-Related Proteins from Multiple Sources ». Journal of Chromatography A 1489 (17 mars 2017): 39‑50. https://doi.org/10.1016/j.chroma.2017.01.031.
  • Francelle, Laetitia, Caroline Lotz, Tiago Outeiro, Emmanuel Brouillet, et Karine Merienne. « Contribution of Neuroepigenetics to Huntington’s Disease ». Frontiers in Human Neuroscience 11 (30 janvier 2017): 17. https://doi.org/10.3389/fnhum.2017.00017.
  • Galan-Rodriguez, Beatriz, Elodie Martin, Emmanuel Brouillet, Nicole Deglon, Sandrine Betuing, et Jocelyne Caboche. « Coupling of D2R Short but Not D2R Long Receptor Isoform to the Rho/ROCK Signaling Pathway Renders Striatal Neurons Vulnerable to Mutant Huntingtin ». European Journal of Neuroscience 45, no 1 (janvier 2017): 198‑206. https://doi.org/10.1111/ejn.13415.
  • Galineau, Laurent, Aurelie Kas, Yulia Worbe, Marion Chaigneau, Anne-Sophie Herard, Martine Guillermier, Thierry Delzescaux, Jean Feger, Philippe Hantraye, et Leon Tremblay. « Cortical Areas Involved in Behavioral Expression of External Pallidum Dysfunctions: A PET Imaging Study in Non-Human Primates ». Neuroimage 146 (1 février 2017): 1025‑37. https://doi.org/10.1016/j.neuroimage.2016.10.039.
  • Gaura, Veronique, Sonia Lavisse, Pierre Payoux, Serge Goldman, Christophe Verny, Pierre Krystkowiak, Philippe Damier, Frederic Supiot, Anne-Catherine Bachoud-Levi, et Philippe Remy. « Association Between Motor Symptoms and Brain Metabolism in Early Huntington Disease ». Jama Neurology 74, no 9 (septembre 2017): 1088‑96. https://doi.org/10.1001/jamaneurol.2017.1200.
  • Goulay, Romain, Julien Flament, Maxime Gauberti, Michael Naveau, Nolwenn Pasquet, Clement Gakuba, Evelyne Emery, et al. « Subarachnoid Hemorrhage Severely Impairs Brain Parenchymal Cerebrospinal Fluid Circulation in Nonhuman Primate ». Stroke 48, no 8 (août 2017): 2301-+. https://doi.org/10.1161/STROKEAHA.117.017014.
  • Hordeaux, J., L. Dubreil, C. Robveille, J. Deniaud, Q. Pascal, B. Dequeant, J. Pailloux, et al. « Long-Term Neurologic and Cardiac Correction by Intrathecal Gene Therapy in Pompe Disease ». Acta Neuropathologica Communications 5 (6 septembre 2017): 66. https://doi.org/10.1186/s40478-017-0464-2.
  • Jeljeli, Mohamed, Valerie Guerin-El Khourouj, Virginie Pommelet, Myriam Hormi, Pierre Gressens, Albert Faye, et Ghislaine Sterkers. « Cytokine/Chemokine Secretion for Detecting Tuberculosis in Quantiferon Supernatants from HIV+ and HIV- Children ». Journal of Infection 75, no 1 (juillet 2017): 77‑80. https://doi.org/10.1016/j.jinf.2017.04.009.
  • Jeziorowska, Dorota, Vincent Fontaine, Charlene Jouve, Eric Villard, Sebastien Dussaud, David Akbar, Valerie Letang, et al. « Differential Sarcomere and Electrophysiological Maturation of Human IPSC-Derived Cardiac Myocytes in Monolayer vs. Aggregation-Based Differentiation Protocols ». International Journal of Molecular Sciences 18, no 6 (juin 2017): 1173. https://doi.org/10.3390/ijms18061173.
  • Kichev, Anton, Pascale Eede, Pierre Gressens, Claire Thornton, et Henrik Hagberg. « Implicating Receptor Activator of NF-Kappa B (RANK)/RANK Ligand Signalling in Microglial Responses to Toll-Like Receptor Stimuli ». Developmental Neuroscience 39, no 1‑4 (2017): 192‑206. https://doi.org/10.1159/000464244.
  • Krishnan, Michelle L., Juliette Van Steenwinckel, Anne-Laure Schang, Jun Yan, Johanna Arnadottir, Tifenn Le Charpentier, Zsolt Csaba, et al. « Integrative Genomics of Microglia Implicates DLG4 (PSD95) in the White Matter Development of Preterm Infants ». Nature Communications 8 (5 septembre 2017): 428. https://doi.org/10.1038/s41467-017-00422-w.
  • Kühl, Jörn-Sven, Felipe Suarez, Godfrey T. Gillett, Philipp G. Hemmati, John A. Snowden, Michael Stadler, Giang L. Vuong, Patrick Aubourg, Wolfgang Köhler, et Renate Arnold. « Long-Term Outcomes of Allogeneic Haematopoietic Stem Cell Transplantation for Adult Cerebral X-Linked Adrenoleukodystrophy ». Brain 140, no 4 (1 avril 2017): 953‑66. https://doi.org/10.1093/brain/awx016.
  • Lahoud, Nathalie, Marie-Helene Abbas, Pascale Salameh, Nadine Saleh, Samer Abes, Hassan Hosseini, et Souheil Gebeily. « A retrospective analysis of 254 acute stroke cases admitted to two university hospitals in Beirut: classification and associated factors ». Functional Neurology 32, no 1 (6 avril 2017): 41‑48. https://doi.org/10.11138/FNeur/2017.32.1.041.
  • Lavaur, Jeremie, Deborah Le Nogue, Marc Lemaire, Jan Pype, Geraldine Farjot, Etienne C. Hirsch, et Patrick P. Michel. « The Noble Gas Xenon Provides Protection and Trophic Stimulation to Midbrain Dopamine Neurons ». Journal of Neurochemistry 142, no 1 (juillet 2017): 14‑28. https://doi.org/10.1111/jnc.14041.
  • Le Douaron, Gael, Laurent Ferrie, Julia E. Sepulveda-Diaz, Blandine Seon-Meniel, Rita Raisman-Vozari, Patrick P. Michel, et Bruno Figadere. « Identification of a Novel 1,4,8-Triazaphenanthrene Derivative as a Neuroprotectant. for Dopamine Neurons Vulnerable in Parkinson’s Disease ». Acs Chemical Neuroscience 8, no 6 (juin 2017): 1222‑31. https://doi.org/10.1021/acschemneuro.6b00385.
  • Le Gras, Stephanie, Celine Keime, Anne Anthony, Caroline Lotz, Lucie De Longprez, Emmanuel Brouillet, Jean-Christophe Cassel, Anne-Laurence Boutillier, et Karine Merienne. « Altered Enhancer Transcription Underlies Huntington’s Disease Striatal Transcriptional Signature ». Scientific Reports 7 (22 février 2017): 42875. https://doi.org/10.1038/srep42875.
  • Lebon, Vincent, Sébastien Jan, Yoann Fontyn, Brice Tiret, Géraldine Pottier, Emilie Jaumain, et Julien Valette. « Using 31P-MRI of hydroxyapatite for bone attenuation correction in PET-MRI: proof of concept in the rodent brain ». EJNMMI Physics 4 (2 mai 2017): 16. https://doi.org/10.1186/s40658-017-0183-6.
  • Li, Tengfei, Matthias Vandesquille, Sylvie Bay, Marc Dhenain, Benoit Delatour, et Pierre Lafaye. « Selection of Similar Single Domain Antibodies from Two Immune VHH Libraries Obtained from Two Alpacas by Using Different Selection Methods ». Immunology Letters 188 (août 2017): 89‑95. https://doi.org/10.1016/j.imlet.2017.07.001.
  • Ligneul, Clemence, Marco Palombo, et Julien Valette. « Metabolite Diffusion up to Very High b in the Mouse Brain In Vivo: Revisiting the Potential Correlation Between Relaxation and Diffusion Properties ». Magnetic Resonance in Medicine 77, no 4 (avril 2017): 1390‑98. https://doi.org/10.1002/mrm.26217.
  • Ligneul, Clemence, et Julien Valette. « Probing Metabolite Diffusion at Ultra-Short Time Scales in the Mouse Brain Using Optimized Oscillating Gradients and “Short”-Echo-Time Diffusion-Weighted MRS ». Nmr in Biomedicine 30, no 1 (janvier 2017): e3671. https://doi.org/10.1002/nbm.3671.
  • Liot, Geraldine, Julien Valette, Jeremy Pepin, Julien Flament, et Emmanuel Brouillet. « Energy Defects in Huntington’s Disease: Why “in Vivo” Evidence Matters ». Biochemical and Biophysical Research Communications 483, no 4 (19 février 2017): 1084‑95. https://doi.org/10.1016/j.bbrc.2016.09.065.
  • Lunven, Marine, et Paolo Bartolomeo. « Attention and Spatial Cognition: Neural and Anatomical Substrates of Visual Neglect ». Annals of Physical and Rehabilitation Medicine 60, no 3 (juin 2017): 124‑29. https://doi.org/10.1016/j.rehab.2016.01.004.
  • Mankodi, Ami, Noura Azzabou, Thomas Bulea, Haimen Reyngoudt, Hirity Shimellis, Yupeng Ren, Eunhee Kim, Kenneth H. Fischbeck, et Pierre G. Carlier. « Skeletal Muscle Water T-2 as a Biomarker of Disease Status and Exercise Effects in Patients with Duchenne Muscular Dystrophy ». Neuromuscular Disorders 27, no 8 (août 2017): 705‑14. https://doi.org/10.1016/j.nmd.2017.04.008.
  • Mannioui, Abdelkrim, Quentin Vauzanges, Jean Baptiste Fini, Esther Henriet, Somya Sekizar, Loris Azoyan, Jean Léon Thomas, et al. « The Xenopus Tadpole: An in Vivo Model to Screen Drugs Favoring Remyelination ». Multiple Sclerosis Journal, 28 juillet 2017, 1352458517721355. https://doi.org/10.1177/1352458517721355.
  • Mas, J.-L., G. Derumeaux, B. Guillon, E. Massardier, H. Hosseini, L. Mechtouff, C. Arquizan, et al. « Patent Foramen Ovale Closure or Anticoagulation vs. Antiplatelets after Stroke ». New England Journal of Medicine 377, no 11 (14 septembre 2017): 1011‑21. https://doi.org/10.1056/NEJMoa1705915.
  • Massart, Renaud, Matthew Suderman, Valerie Mongrain, et Moshe Szyf. « DNA Methylation and Transcription Onset in the Brain ». Epigenomics 9, no 6 (juin 2017): 797‑809. https://doi.org/10.2217/epi-2016-0184.
  • Matet, Alexandre, Corinne Kostic, Alexis-Pierre Bemelmans, Alexandre Moulin, Serge G. Rosolen, Samia Martin, Fulvio Mavilio, et al. « Evaluation of Tolerance to Lentiviral LV-RPE65 Gene Therapy Vector after Subretinal Delivery in Non-Human Primates ». Translational Research 188 (octobre 2017): 40‑57. https://doi.org/10.1016/j.trsl.2017.06.012.
  • Mazuel, Leslie, Jordy Blanc, Cendrine Repond, Veronique Bouchaud, Gerard Raffard, Nicole Deglon, Gilles Bonvento, Luc Pellerin, et Anne-Karine Bouzier-Sore. « A Neuronal MCT2 Knockdown in the Rat Somatosensory Cortex Reduces Both the NMR Lactate Signal and the BOLD Response during Whisker Stimulation ». Plos One 12, no 4 (7 avril 2017): e0174990. https://doi.org/10.1371/journal.pone.0174990.
  • McAdams, Ryan M., Bobbi Fleiss, Christopher Traudt, Leslie Schwendimann, Jessica M. Snyder, Robin L. Haynes, Niranjana Natarajan, Pierre Gressens, et Sandra E. Juul. « Long-Term Neuropathological Changes Associated with Cerebral Palsy in a Nonhuman Primate Model of Hypoxic-Ischemic Encephalopathy ». Developmental Neuroscience 39, no 1‑4 (2017): 124‑40. https://doi.org/10.1159/000470903.
  • Meertens, Laurent, Athena Labeau, Ophelie Dejarnac, Sara Cipriani, Laura Sinigaglia, Lucie Bonnet-Madin, Tifenn Le Charpentier, et al. « Axl Mediates ZIKA Virus Entry in Human Glial Cells and Modulates Innate Immune Responses ». Cell Reports 18, no 2 (10 janvier 2017): 324‑33. https://doi.org/10.1016/j.celrep.2016.12.045.
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  • Moss, Davina J. Hensman, Antonio F. Pardinas, Douglas Langbehn, Kitty Lo, Blair R. Leavitt, Raymund Roos, Alexandra Durr, et al. « Identification of Genetic Variants Associated with Huntington’s Disease Progression: A Genome-Wide Association Study ». Lancet Neurology 16, no 9 (septembre 2017): 701‑11. https://doi.org/10.1016/S1474-4422(17)30161-8.
  • Nistico, Robert, Eric Salter, Celine Nicolas, Marco Feligioni, Dalila Mango, Zuner A. Bortolotto, Pierre Gressens, Graham L. Collingridge, et Stephane Peineau. « Synaptoimmunology - Roles in Health and Disease ». Molecular Brain 10 (20 juin 2017): 26. https://doi.org/10.1186/s13041-017-0308-9.
  • Palombo, Marco, Clemence Ligneul, Edwin Hernandez-Garzon, et Julien Valette. « Can We Detect the Effect of Spines and Leaflets on the Diffusion of Brain Intracellular Metabolites? » NeuroImage 182 (08 2017): 283‑93. https://doi.org/10.1016/j.neuroimage.2017.05.003.
  • Palombo, Marco, Clemence Ligneul, et Julien Valette. « Modeling Diffusion of Intracellular Metabolites in the Mouse Brain up to Very High Diffusion-Weighting: Diffusion in Long Fibers (Almost) Accounts for Non-Monoexponential Attenuation ». Magnetic Resonance in Medicine 77, no 1 (janvier 2017): 343‑50. https://doi.org/10.1002/mrm.26548.
  • Papadopoulos, Constantinos, Pascal Laforet, Juliette Nectoux, Tanya Stojkovic, Karim Wahbi, Robert-Yves Carlier, Pierre G. Carlier, et al. « Hyperckemia and Myalgia Are Common Presentations of Anoctamin-5-Related Myopathy in French Patients ». Muscle & Nerve 56, no 6 (décembre 2017): 1096‑1100. https://doi.org/10.1002/mus.25608.
  • Passemard, Sandrine, Franck Perez, Emilie Colin-Lemesre, Sowmyalakshmi Rasika, Pierre Gressens, et Vincent El Ghouzzi. « Golgi Trafficking Defects in Postnatal Microcephaly: The Evidence for “Golgipathies” ». Progress in Neurobiology 153 (juin 2017): 46‑63. https://doi.org/10.1016/j.pneurobio.2017.03.007.
  • Peigné, Sophie, Stéphanie Chhun, Michel Tod, Elisabeth Rey, Christelle Rodrigues, Catherine Chiron, Gérard Pons, et Vincent Jullien. « Population Pharmacokinetics of Stiripentol in Paediatric Patients with Dravet Syndrome Treated with Stiripentol, Valproate and Clobazam Combination Therapy ». Clinical Pharmacokinetics, 17 août 2017. https://doi.org/10.1007/s40262-017-0592-7.
  • Piguet, Francoise, Sandro Alves, et Nathalie Cartier. « Clinical Gene Therapy for Neurodegenerative Diseases: Past, Present, and Future ». Human Gene Therapy 28, no 11 (novembre 2017): 988‑1003. https://doi.org/10.1089/hum.2017.160.
  • Plante-Bordeneuve, Violaine, Farida Gorram, Hayet Salhi, Tarik Nordine, Samar S. Ayache, Philippe Le Corvoisier, Daniel Azoulay, Cyrille Feray, Thibaud Damy, et Jean-Pascal Lefaucheur. « Long-Term Treatment of Transthyretin Familial Amyloid Polyneuropathy with Tafamidis: A Clinical and Neurophysiological Study ». Journal of Neurology 264, no 2 (février 2017): 268‑76. https://doi.org/10.1007/s00415-016-8337-3.
  • Pourabdolhossein, Fereshteh, Sara Gil-Perotin, Paula Garcia-Belda, Aurelien Dauphin, Sabah Mozafari, Vanja Tepavcevic, Jose Manuel Garcia Verdugo, et Anne Baron-Van Evercooren. « Inflammatory Demyelination Induces Ependymal Modifications Concomitant to Activation of Adult (SVZ) Stem Cell Proliferation ». Glia 65, no 5 (mai 2017): 756‑72. https://doi.org/10.1002/glia.23124.
  • Remaud, Sylvie, Fernando C. Ortiz, Marine Perret-Jeanneret, Marie-Stephane Aigrot, Jean-David Gothie, Csaba Fekete, Zsuzsanna Kvarta-Papp, et al. « Transient Hypothyroidism Favors Oligodendrocyte Generation Providing Functional Remyelination in the Adult Mouse Brain ». Elife 6 (6 septembre 2017): e29996. https://doi.org/10.7554/eLife.29996.001.
  • Renkilaraj, Majistor Raj Luxman Maglorius, Lucas Baudouin, Claire M. Wells, Mohamed Doulazmi, Rosine Wehrle, Vidjeacoumary Cannaya, Corinne Bachelin, et al. « The Intellectual Disability Protein PAK3 Regulates Oligodendrocyte Precursor Cell Differentiation ». Neurobiology of Disease 98 (février 2017): 137‑48. https://doi.org/10.1016/j.nbd.2016.12.004.
  • Richetto, Juliet, Renaud Massart, Ulrike Weber-Stadlbauer, Moshe Szyf, Marco A. Riva, et Urs Meyer. « Genome-Wide DNA Methylation Changes in a Mouse Model of Infection-Mediated Neurodevelopmental Disorders ». Biological Psychiatry 81, no 3 (1 février 2017): 265‑76. https://doi.org/10.1016/j.biopsych.2016.08.010.
  • Rodrigues, Christelle, Catherine Chiron, Elisabeth Rey, Olivier Dulac, Emmanuelle Comets, Gerard Pons, et Vincent Jullien. « Population Pharmacokinetics of Oxcarbazepine and Its Monohydroxy Derivative in Epileptic Children ». British Journal of Clinical Pharmacology 83, no 12 (décembre 2017): 2695‑2708. https://doi.org/10.1111/bcp.13392.
  • Sellier, Chantal, Ronald A. M. Buijsen, Fang He, Sam Natla, Laura Jung, Philippe Tropel, Angeline Gaucherot, et al. « Translation of Expanded CGG Repeats into FMRpolyG Is Pathogenic and May Contribute to Fragile X Tremor Ataxia Syndrome ». Neuron 93, no 2 (18 janvier 2017): 331‑47. https://doi.org/10.1016/j.neuron.2016.12.016.
  • Sergent, Claire, Frederic Faugeras, Benjamin Rohaut, Fabien Perrin, Melanie Valente, Catherine Tallon-Baudry, Laurent Cohen, et Lionel Naccache. « Multidimensional Cognitive Evaluation of Patients with Disorders of Consciousness Using EEG: A Proof of Concept Study ». Neuroimage-Clinical 13 (2017): 455‑69. https://doi.org/10.1016/j.nicl.2016.12.004.
  • Shiow, Lawrence R., Geraldine Favrais, Lucas Schirmer, Anne-Laure Schang, Sara Cipriani, Christian Andres, Jaclyn N. Wright, et al. « Reactive Astrocyte COX2-PGE2 Production Inhibits Oligodendrocyte Maturation in Neonatal White Matter Injury ». Glia 65, no 12 (décembre 2017): 2024‑37. https://doi.org/10.1002/glia.23212.
  • Taib, Toufik, Claire Leconte, Juliette Van Steenwinckel, Angelo H. Cho, Bruno Palmier, Egle Torsello, Rene Lai Kuen, et al. « Neuroinflammation, Myelin and Behavior: Temporal Patterns Following Mild Traumatic Brain Injury in Mice ». PLOS ONE 12, no 9 (14 septembre 2017): e0184811. https://doi.org/10.1371/journal.pone.0184811.
  • Thibaud, J. L., B. Matot, I. Barthelemy, Y. Fromes, S. Blot, et P. G. Carlier. « Anatomical and Mesoscopic Characterization of the Dystrophic Diaphragm: An in Vivo Nuclear Magnetic Resonance Imaging Study in the Golden Retriever Muscular Dystrophy Dog ». Neuromuscular Disorders 27, no 4 (avril 2017): 315‑25. https://doi.org/10.1016/j.nmd.2017.02.003.
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The 12th annual international partnering conference BioEurope Spring will take place March 12-14, 2018, in Amsterdam.

With a focus on European innovation and global collaboration, BIO-Europe Spring is the premier springtime partnering conference bringing together a “whoʼs who” from biotech, pharma and finance in the most innovative biopharma clusters in Europe.

Ali Aït-Ikhlef, NeurATRIS business development manager, will be there: This email address is being protected from spambots. You need JavaScript enabled to view it.and meet him there !

NeurATRIS launches a call aimed at fostering collaborative projects between NeurATRIS members and scientific community (academic and clinical laboratories and biotech companies) involved in neurodegenerative disease projects with a grant up to 50 000 € for the successful applicants.

Academic research laboratories and biotechs are welcome to apply. Applicant consortia may include a private partner, but only academics and biotechs will be eligible for funding.

NeurATRIS at BioFIT 2017 (28 -29 November 2017, Strasbourg)

NeurATRIS will be participating to BioFIT convention on November 28-29, 2017, in Strasbourg, the leading partnering event in Europe for technology transfer, academia-industry collaborations and early-stage innovations in the field of Life Sciences.

From October 7 to 15, 2017, come to the fête de la science ! Come experiment, visit laboratories, increase your taste for science, chat with researchers everywhere in France. All events are free and organized for broad audiences of every age. A unique opportunity for the younger ones to discover science and maybe future vocations.

In particular, you can discover the activities of NeurATRIS researchers in several of our labs:

Registrations for the first edition of « Translational neuroscience : challenges and opportunities » are now open !

NeurATRIS and Medicen Paris Région are very happy to invite you to this event on November 20, 2017, at the Cité Universitaire Internationale de Paris.

Gathering experts in neurodegenerative diseases, this event will foster interactions between researchers, clinicians, biotech and pharmaceutical companies.

You will be able to:

  • Meet researchers and clinicians with cutting edge expertise in neurodegenerative diseases
  • Hear pharmaceutical companies presenting their views and needs
  • Share your assets and needs in a flash during a pitch session
  • Build R&D collaborative projects during a matchmaking session

Online registration is free and mandatory before November 5 : https://tranlational-neuroscience.b2match.io/

Looking forward to seeing you there !

NeurATRIS and Medicen Paris Région are very happy to invite you to the first edition of “Translational neuroscience: challenges and opportunities”, on November 20, 2017, at the Cité Universitaire Internationale de Paris.

Gathering experts in neurodegenerative diseases, this event will foster interactions between researchers, clinicians, biotech and pharmaceutical companies.

You will be able to:

  • Meet researchers and clinicians with cutting edge expertise in neurodegenerative diseases
  • Hear pharmaceutical companies presenting their views and needs
  • Share your assets and needs in a flash during a pitch session
  • Build R&D collaborative projects during a matchmaking session

Looking forward to seeing you there !

 

The European Research Infrastructure for Translational Medicine (EATRIS) organizes its third bi-annual conference, “Translational Medicine 2017” on September 24-26 2017 at Corinthia Hotel in Prague.

This event, open to a wide range of stakeholders from academic researchers, funders to industry players and regulators, will bring together international experts to discuss the latest advancements in translational medicine.

The theme of this third edition, “Enhancing Predictivity in Medicines Development” will focus on bringing together the latest technologies to increase success in drug development, from novel in vitro systems to new biomarkers or clinical trial methodology for patient selection and stratification.

For this year’s edition, you will hear from – among others – Mark Schmidt (Senior Director, Janssen Research and Development), Philip Murphy (Head, Experimental Medicine Imaging, GSK), Christopher Austin (NIH-NCATS, United States). Find out all about the conference’s keynote speakers.

The programme also includes a pre-conference day on Sunday, September 24, that will be dedicated to a series of educational workshops tackling topics in the field such as molecular imaging, biomarker validation or potency assays for ATMP’s and vaccines.

Translational Medicine 2017 also welcomes abstract submissions until May 15, 2017!

For more information, please visit: www.translationalmedicine2017.eu

Questions? Send an email to: This email address is being protected from spambots. You need JavaScript enabled to view it.

NeurATRIS will attend this event, do not hesitate to This email address is being protected from spambots. You need JavaScript enabled to view it.us to set up a meeting.

Cognitive decline is one of the most debilitating manifestations of disease progression in Parkinson's disease and is a key determinant of a patient's quality of life and independence.1 The ability to predict and to manage this complication is highly relevant for recruitment into and stratification of clinical trials, particularly those designed to slow disease progression and to prevent dementia. Although a multitude of drugs for Parkinson's disease is available to improve motor aspects of the disease, these do not have a major effect on cognitive decline.

The authors of a study published in The Lancet Neurology aimed to develop a clinical–genetic score to predict global cognitive impairment in patients with the disease. This international study involving clinicians from AP-HP, Inserm, UPMC at ICM was conducted using 9 cohorts gathering 3200 patients. The resulting predictive algorithm provides a potential test for future cognitive health or impairment in patients with Parkinson's disease. This model could improve trials of cognitive interventions and inform on prognosis.

In France, the DIG-PD cohort, coordinated by Pr Jean-Christophe Corvol at ICM, followed more than 400 patients for 6 years.

NeurATRIS will be participating to RegMed Europe on July 7, 2017, in Paris, the first european matchmaking event on regenerative medicine.

Participants will get information about the ongoing regenerative medicine challenges and topics, learn about the major European ecosystems, get the chance to present their innovative projects, and meet the European actors in their field to build international partnerships.

Main topics:

  • Cell therapy
  • Gene therapy
  • Biomaterials
  • Tissue engineering

You will be able to meet our business developper, Ali AIT-IKHLEF, who can tell you more about NeurATRIS assets to work alongside in your translational projects in the Neuroscience field for the characterization of neurodegenerative diseases.

Do not hesitate to This email address is being protected from spambots. You need JavaScript enabled to view it.us to set up a meeting.

NeurATRIS

NeurATRIS is pleased to announce that we will be participating to « Médecine Translationnelle au service de l’innovation Thérapeutique : Enjeux, Besoins et Opportunités » (13th June, Paris)

The goal of this day is to provide an overview of translational medicine platforms of key account (academic and pharmaceutical industries) in order to understand how they work, their needs and their roles in the value chain of discovery and development of therapeutic solutions.

This is a unique opportunity to hear P. HANTRAYE, NeurATRIS director, and learn more about NeurATRIS assets to work alongside in your translational projects in the Neuroscience field for the characterization of neurodegenerative diseases.

Do not hesitate to contact us to set up a meeting.

 

NeurATRIS

On the occasion of World Multiple Sclerosis day, on May 31st, the french magazine "Sciences et Avenir" dedicates an article to promising recent work from Catherine Lubetzki's team at the Brain and Spine Institute (ICM) in Paris.

Several studies from the team have shown the importance of the remyelination process in patient health state. In its most frequent form, multiple sclerosis is indeed charaterized by inflammatory bursts in the central nervous system (brain and spine), followed by respite periods during which myelin is partially rebuilt.

New imaging techniques developped at ICM, more precise than MRI, allowed to show that this reparation "potential" differs a lot among patients : by injecting a specific tracer that fixes on myelin, before performing a PET scan, the degree of myelin degradation can be measured.

You can find the complete article (in French) on the magazine website.

NeurATRIS is pleased to announce that we will be participating to Bio-Europe Spring (20th – 22nd March, Barcelona)

BIO-EUROPE SPRING is the premier springtime partnering conference bringing together a “whoʼs who” from biotech, pharma and finance in Europe's most innovative biopharma clusters.

This is a unique opportunity to learn more about NeurATRIS assets to work alongside in your translational projects in the Neuroscience field for the characterization of neurodegenerative diseases.

Do not hesitate to This email address is being protected from spambots. You need JavaScript enabled to view it. to set up a meeting.

NeurATRIS

Multiple sclerosis is an inflammatory disease of the nervous central system leading to a progressive destruction of the myelin sheath surrounding the axons, essential for their protection and for the transmission of the nerve impulse. Bruno Stankoff and Catherine Lubetzki’s team developed a cutting-edge imaging technique which makes possible to visualize neuron demyelination and remyelination and to quantify their degeneration. These results, published in Annals of Neurology, open the way to better treatment for patients and to the evaluation of novel remyelination therapies.

http://icm-institute.org/en/actualite/measure-multiple-sclerosis-progression-with-a-cutting-edge-technique/

 

Wednesday September the 21st, World Alzheimer's Day, will be held at CEA of Fontenay aux roses a thesis defense by Romain Fol on this topic. The discussion will precisely focus on the “ Consequences of APP soluble forms overexpression in memory processes and its therapeutical application to Alzheimer’s disease.”

http://icm-institute.org/en/actualite/the-silent-stage-of-alzheimers-disease/

A major international conceptual diagnostic criteria and conceptual breakthrough program has been successfully launched and published, led by the UPMC and ICM researchers Professor Bruno Dubois and Professor Harald Hampel (AXA – UPMC Chair) who coordinated a distinguished group of major international key opinion leaders, based on the dynamic conceptual evolution of the paradigm of preclinical Alzheimer’s disease (AD), in the March Issue of the leading international Alzheimer Journal Alzheimer’s & Dementia, The Journal of the Alzheimer’s Association.

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