Research support

In 2017, NeurATRIS launched a 1st call for collaborative projects entitled "A new funding for innovative and collaborative neurodegenerative disease projects" and specifically dedicated to projects coming from academic research. The objective of this call was to foster collaborative projects between NeurATRIS members and the scientific community involved in neurodegenerative diseases. The winners benefited from access to NeurATRIS' technological platforms (see "NeurATRIS' platforms"), as well as from its expertise and scientific and technical support in advanced neuroimaging technologies, cellular and animal models of disease, behavioural tests and viral vector production. Fourteen (14) projects, each subsidised to the tune of €50,000, have been selected for the 2018-2020 period.
NeurATRIS first Call for projects
2018
Academic Partner: IGBMC (Strasbourg, France)
NeurATRIS Partner: ICM
Project Manager: A. Giangrande and B. Nait-Oumesmar
Field of study: In vivo evaluation and therapeutic efficacy
Key words: Neuroinflammation, Demyelination/Remyelination, Microglial cells, Experimental Autoimmune Encephalomyelitis (EAE), Multiple sclerosis
Academic Partner: GIN (Grenoble, France)
NeurATRIS Partner: CEA-MIRCen
Project Manager: S. Humbert and E. Brouillet
Field of study: In vivo evaluation and therapeutic efficacy
Key words: Huntington's disease, nuclear magnetic resonance imaging (MRI), white matter, mouse models
Academic Partner: INRA (Bordeaux, France)
NeurATRIS Partner: Hôpital Robert-Debré - UMR1141
Project Manager: S. Layé and P. Gressens
Field of study: In vivo evaluation and therapeutic efficacy
Key words: Nutrition, lipids, microglia, autism, brain development
Academic Partner: ICBM (Chile)
NeurATRIS Partner: CEA-MIRCen
Project Manager: F.C. Ortiz and C. Escartin
Field of study: In vivo evaluation and therapeutic efficacy
Key words: Astrocyte reactivity, oligodendrocyte precursor cells, myelin, remyelination, Multiple Sclerosis
Academic Partner: MNHN (Paris, France)
NeurATRIS Partner: ICM
Project Manager: S. Remaud and B. Zalc
Field of study: Drug therapies
Key words: Adult neural stem cells, oligodendrocyte, thyroid hormone, endocrine disruptors
2019
Academic Partner: INCC (Paris, France)
NeurATRIS Partner: CEA-MIRCen
Project Manager: C. Agulhon and A. Bemelmans
Field of study: In vivo evaluation and therapeutic efficacy
Key words: Neuron-glia interactions, satellite glia, proprioceptive neurons, sensory motor function
Academic Partner: UMASS (Massachussetts, USA)
NeurATRIS Partner: Hôpital Bicêtre - N-BIPS
Project Manager: G. Gao, T. Mackenzie and P. Bougnères
Field of study: Gene Therapy
Key words: Metachromatic leukodystrophy (ML), Recombinant adeno-associated virus (rAAV), Oligodendrocytess
Academic Partner: UVSQ (Yvelines, France)
NeurATRIS Partner: CEA-MIRCen
Project Manager: N. Le Floch-Leleu and G. Liot
Field of study: In vivo evaluation and therapeutic efficacy
Key words: Alzheimer's disease, Parkinson's disease, mitochondria, sideroflexin, cell death
Academic Partner: ICVS et School of Medicine, University of Minho (Braga, Portugal)
NeurATRIS Partner: CEA-NeuroSpin
Project Manager: F. Marques and F. Boumezbeur
Field of study: In vivo evaluation and therapeutic efficacy
Key words: Astrocytes, Multiple Sclerosis, experimental autoimmune encephalomyelitis, neuroimaging, magnetic resonance spectroscopy, citric acid cycle, glycolysis
Academic Partner: IDV (Paris, France)
NeurATRIS Partner: ICM
Project Manager: J. Sahel, S. Mohand-Saïd and C. Lubetzki, C. Louapre
Field of study: In vivo evaluation and therapeutic efficacy
Key words: Magnetoencephalography (MEG), optic neuritis, multiple sclerosis, electrical stimulation, remyelination
Academic Partner: Achucarro Basque Center for Neuroscience (Leioa, Spain)
NeurATRIS Partner: ICM
Project Manager: V. Tepavcevic and B. Nait-Oumesmar
Field of study: In vivo evaluation and therapeutic efficacy
Key words: Myelin, oligodendrocyte precursor cells, remyelination, lactate, Monocarboxylate transporter 2 (MCT2), energy metabolism, Multiple Sclerosise
2020
Academic Partner: UBA (Barcelona, Spain)
NeurATRIS Partner: INRAE-UMR703
Project Manager: A. Bosch Merino and M.A. Colle
Field of study: In vivo evaluation andtherapeutic efficacy
Key words: Proximal Spinal Muscular Atrophy type 2 (SMA type 2), neuromuscular junction, gene therapy, mouse model
Academic Partner: UMASS (Massachussetts, USA)
NeurATRIS Partner: Hôpital Bicêtre - N-BIPS & CEA-MIRCen
Project Manager: G. Gao and E. Traiffort, J. Flament
Field of study: Gene Therapy
Key words: AAV vectors, oligodendrocytes, remyelination
Academic Partner: UMM, (Heidelberg, Germany)
NeurATRIS Partner: ICM
Project Manager: J. Weishaupt and C. S. Lobsiger
Field of study: In vivo evaluation and therapeutic efficacy
Key words: Neurodegeneration, aging, neuroinflammation, microglia, motor neurons,  autophagy, RNAseq
Building on its success, NeurATRIS launched in 2021 a second call for projects untitled « Second call for innovative and collaborative neurodegenerative disease projects». Thirteen (13) new collaborative projects have been awarded up to €100,000 per project for the period 2022-2024.
NeurATRIS 2nd Call
Academic Partner: University of Bordeaux (Bordeaux, France)
NeurATRIS Partner: Hôpital Robert-Debré - UMR1141
Project Manager: J. Badaut and J. Van Steenwinckel
Field of study: In vivo evaluation and therapeutic efficacy
Key words: Traumatic brain injury, neuroinflammation, astrocytes, microglia
Academic Partner: NeuroPSI (Saclay, France)
NeurATRIS Partner: ICM
Project Manager: J-V. Barnier and L. Bouslama
Field of study: In vivo evaluation and therapeutic efficacy
Key words: Autism spectrum disorders (ASD), P21-activated kinases (PAK), synapse, myelin
Academic Partner: IBPS, Sorbonne University (Paris, France)
NeurATRIS Partner: CEA-MIRCen
Project Manager: S. Betuing and C. Escartin
Field of study: Gene Therapy & In vivo evaluation and therapeutic efficacy
Key words: Huntington's disease, AAV vectors, ZQ175 mice, striatum, cholesterol metabolism, nuclear magnetic resonance imaging (MRI), psychiatric symptoms
Academic Partner: Faculty of Medecine - Sorbonne University (Paris, France)
NeurATRIS Partner: ICM
Project Manager: A. Carpentier and B. Delatourn
Field of study: In vivo evaluation and therapeutic efficacy & Drug Therapies
Key words: Alzheimer's disease, immunotherapy, tau, blood-brain barrier, single domain antibodies (nanobodies), translational development
Academic Partner: Department of Paediatric Metabolic Diseases, Necker-Children's Hospital (Paris, France)
NeurATRIS Partner: INRAE-UMR703
Project Manager: P. de Lonlay and M-A. Colle
Field of study: Drug Therapies
Key words: Pompe disease, neurological symptoms, central nervous system, neuromuscular junction, pathogenesis
Academic Partner: IBPS, Sorbonne University (Paris-France)
NeurATRIS Partner: ICM
Project Manager: C. El Amri and B. Nait-Oumesmar
Field of study: Drug Therapies
Key words: Oligodendrocyte, remyelination, multiple sclerosis, serine protease, kallikreine
Academic Partner: FIMABIS-IBIMA (Málaga, Spain)
NeurATRIS Partner: ICM
Project Manager: B. García Díaz and A. Baron Van Evercooren
Field of study: In vivo evaluation and therapeutic efficacy
Key words: Oligodendrocytes, metabolism, blood vessels, myelin repair
Academic Partner: CryoCapCell (Paris, France)
NeurATRIS Partner: CEA- MIRCen and U1195 - N-BIPS
Project Manager: X. Heiligenstein and P. Bougnères
Field of study: In vivo evaluation and therapeutic efficacy
Key words: Correlative electron microscopy (CLEM), nuclear magnetic resonance imaging (MRI), oligodendroglial and other brain cell lines, immunofluorescencee
Academic Partner: University of Paris Cité (Paris, France)
NeurATRIS Partner: Hôpital Robert-Debré - UMR1141
Project Manager: V. Mezger and P. Gressens
Field of study: In vivo evaluation and therapeutic efficacy
Key words: Oligodendrocyte precursors (OPC), neuroinflammation, neurodevelopment
Academic Partner: IRTOMIT, University of Poitiers (Poitiers, France)
NeurATRIS Partner: CEA-MIRCen
Project Manager: L. Pellerin and C. Baligand
Field of study: In vivo evaluation and therapeutic efficacy
Key words: Metabolic Imaging, Nuclear Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET), Oxygen and Glucose Metabolism, Medium Chain Triglycerides (MCTs), Glucose Transporters GLUT3, Lactic Shuttle
Academic Partner: IBPS, Sorbonne University (Paris-France)
NeurATRIS Partner: CEA-MIRCen
Project Manager: J-M. Peyrin and K. Cambon
Field of study: In vivo evaluation and therapeutic efficacy
Key words: Taupathies, glial cells, gene transfer
 Academic Partner: LuMIn, Université Paris-Saclay (Saclay, France)
NeurATRIS Partner: ICM
Project Manager: B. Potier and S. Marty
Field of study: Gene Therapy
Key words: Alzheimer's disease, gene therapy, Adeno-Associated Virus (AAV), Apolipoprotein E
Academic Partner: MNHN (Paris, France)
NeurATRIS Partner: ICM
Project Manager: S. Remaud and B. Zalc
Field of study: In vivo evaluation and therapeutic efficacy
Key words: Adult neural stem cells, oligodendrocyte, myelin, behaviour, endocrine disruptors