CEA Paris- Saclay / MIRCen

The CEA- MIRCen platforms are dedicated to the exploration and validation of concepts, as well as to the preclinical evaluation of new gene, cell or drug therapeutic strategies, mainly in the field of neurodegenerative diseases.

They are articulated along a translational axis ranging from in vitro to pre-clinical and clinical data analysis.
MOLECULAR BIOLOGY - CELL CULTURE - VIRAL PRODUCTION - BIOCHEMISTRY PLATFORM:
This platform offers methodologies, equipment and expertise dedicated to the development of viral vectors of the AAV and lentivirus type, their production and characterisation in order to the develop pathological models and to assess new therapeutic approaches.
(https://jacob.cea.fr/drf/ifrancoisjacob/Pages/Departements/MIRCen/Plateformes/Biologie-moleculaire.aspx)

FUNCTIONAL EXPLORATIONS PLATFORM:
This platform brings together the technologies needed to develop relevant animal models of neurodegenerative diseases and to evaluate the effectiveness of new therapies.
(https://jacob.cea.fr/drf/ifrancoisjacob/Pages/Departements/MIRCen/Plateformes/Explorations-fonctionnelles.aspx)

APTAMERES PLATFORM:
This platform offers methodologies, equipment and expertise for the selection, characterisation and engineering of aptamers, nucleic acid-based ligands with antibody-like properties.
(https://jacob.cea.fr/drf/ifrancoisjacob/Pages/Departements/MIRCen/Plateformes/Aptameres.aspx)

PROTEOMICS PLATFORM:
This platform offers proteomics methodologies and mass spectrometry techniques to identify, characterise and quantify proteins and some of their modifications from samples of varying complexity.
(https://jacob.cea.fr/drf/ifrancoisjacob/Pages/Departements/MIRCen/Plateformes/Proteomique.aspx)
NMR IMAGING PLATFORM: Cyclone 18/18 IBA cyclotron
RADIOCHIMIC PLATFORM: Shielded enclosures
RADIOCHEMISTRY PLATFORM:
The radiochemistry platform enables the radiosynthesis and development of new radiotracers specific to biological targets involved in pathological processes.
(https://jacob.cea.fr/drf/ifrancoisjacob/Pages/Departements/MIRCen/Plateformes/Radiochimie.aspx)

PET IMAGING PLATFORM:
The PET imaging platform provides its expertise for the validation of radiotracers in animal models, the validation of new animal models and the evaluation of new therapies with a view to their transfer to clinical research.
(https://jacob.cea.fr/drf/ifrancoisjacob/Pages/Departements/MIRCen/Plateformes/Imagerie-TEP.aspx)
NMR IMAGING PLATFORM:
The magnetic resonance imaging platform develops and validates high-resolution imaging and multinuclear spectrometry techniques for accessing central nervous system activity in various animal models.
(https://jacob.cea.fr/drf/ifrancoisjacob/Pages/Departements/MIRCen/Plateformes/Imagerie-RMN.aspx)

HISTOLOGY AND MICROSCOPIC ANALYSIS PLATFORM:
The histology and microscopic analysis platform is equipped with high-tech equipment for macroscopic, histological and molecular studies in non-human primates and rodents.
(https://jacob.cea.fr/drf/ifrancoisjacob/Pages/Departements/MIRCen/Plateformes/Histologie-Analyses-microscopiques.aspx)

CLINICAL IMAGING PLATFORM:
The clinical imaging platform is equipped with the high-resolution imaging tools necessary to carry out PET imaging examinations aimed at identifying biomarkers and/or studying the effect of innovative therapies.
(https://jacob.cea.fr/drf/ifrancoisjacob/Pages/Departements/MIRCen/Plateformes/Imagerie-clinique.aspx)
RADIOCHIMIC PLATFORM: Pre-clinical 11.7 Tesla MRI